Department of Chemistry
A headshot

Christian Hilty
Graduate Advisor

Other Affiliations

Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-862-3099

Researcher ID

Current Activities

We are developing and applying Magnetic resonance techniques for the investigation of rapid processes and molecular dynamics. Hyperpolarization of nuclear spins yields unprecedented levels of signal, which enables us to acquire NMR spectra of reactions as they occur, in real time. Applications of these techniques include the fields of enzyme catalysis, reactions in organic chemistry, polymers, and more.

To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments, and investigate the dynamics of hyperpolarized spin systems.

Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants of protein structure and function, including of membrane proteins.

Educational Background

Diploma, 1999, Swiss Federal Institute of Technology (ETH) Zurich

Ph.D., 2004, Swiss Federal Institute of Technology (ETH) Zurich

Postdoctoral Fellow 2004-2006, University of California, Berkeley and Lawrence Berkeley National Laboratory

Awards & Recognition

  • Camille & Henry Dreyfus New Faculty Award 2006
  • Raymond Andrew Prize (Ampere Society) 2005

Selected Publications

  • Qi, C., Wang, Y. and Hilty, C. Application of Relaxation Dispersion of Hyperpolarized 13C Spins to Protein-Ligand Binding. Angew. Chem. Int. Ed. 60(45): 24018-24021 (2021).
  • Mandal, R., Pham, P. and Hilty, C. Characterization of protein–ligand interactions by SABRE. Chem. Sci. 12(39): 12950-12958 (2021).
  • Kim, Y., Samouei, H. and Hilty, C. Polyolefin Catalysis of Propene, 1-Butene and Isobutene Monitored Using Hyperpolarized NMR. Chem. Sci. 12(8): 2823-2828 (2021).
  • Wang, Y., Kim, J. and Hilty, C. Determination of protein-ligand binding modes using fast multi-dimensional NMR with hyperpolarization. Chem. Sci. 11(23): 5935-5943 (2020).
  • Pham, P. and Hilty, C. Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates. Chem. Commun. 56(98): 15466-15469 (2020).