Department of Chemistry
A headshot of Joanna San Pedro

Joanna San Pedro

Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-862-2795
Areas of Interest
  • Biological Organic Chemistry
  • Chemical Education
  • Mentoring

Current Activities

I am currently teaching Chem 107 (General Chemistry for Engineering Students) and Chem 227 (Organic Chemistry I). Aside from my lecture courses, I am also involved in assisting in the technical coordination of the introductory general chemistry laboratory courses (Chem 111 H/M and Chem 112 H/M) specific for our honors and Chemistry major freshmen students.

My research interests lie at the interface of biology and chemistry, specifically in developing practical biological tools and methods to gain a much deeper understanding of how specific cellular processes work. At TAMU, I work in collaboration with the Sczepanski Group in designing and developing genetically encoded tags for imaging RNA by electron microscopy.

Educational Background

Ph.D. in Chemistry, Johns Hopkins University, Baltimore, MD 2014
My thesis was centered on studying the chemical mechanism by which DNA is damaged upon treatment with ionizing radiation and a potent antitumor enediyne antibiotic (C-1027). Photo-caged precursors of several reactive nucleobase intermediates were synthesized, which allowed rigorous reactivity studies between DNA and various repair enzymes and small molecules.

Postdoctoral Research Associate, Salk Institute for Biological Studies, La Jolla, CA 2014 – 2017

Visiting Research Scholar, Texas A&M University, College Station, TX 2015 – 2017
After my PhD, I moved to Salk to gain more experience in biological research and my project involved developing general methods for genome-wide mapping of viral protein-DNA and global mapping of specific RNA-DNA interactions.

Selected Publications

  • San Pedro, J. M. N.; Greenberg, M. M. 5,6-Dihydropyrimidine Peroxyl Radical Reactivity in DNA. J. Am. Chem. Soc. 2014, 136, 3928
  • San Pedro, J. M. N.; Greenberg, M. M.Photochemical control of DNA structure via radical disproportionation. ChemBioChem, 2013, 14, 1590
  • San Pedro, J. M. N.; Beerman, T. A.; Greenberg, M. M. DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases. Bioorg. & Med. Chem. 2012, 20, 474
  • San Pedro, J. M. N.; Greenberg, M. M. Photochemical generation and reactivity of the major hydroxyl radical adduct of thymidine. Org. Lett. 2012, 14, 2866