We are developing and applying Magnetic resonance techniques for the investigation of rapid processes and
molecular dynamics. Hyperpolarization of nuclear spins yields unprecedented levels of signal, which enables us
to acquire NMR spectra of reactions as they occur, in real time. Applications of these techniques include the
fields of enzyme catalysis, reactions in organic chemistry, polymers, and more.
To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments,
and investigate the dynamics of hyperpolarized spin systems.
Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants
of protein structure and function, including of membrane proteins.
Diploma, 1999, Swiss Federal Institute of Technology (ETH) Zurich
Ph.D., 2004, Swiss Federal Institute of Technology (ETH) Zurich
Postdoctoral Fellow 2004-2006, University of California, Berkeley and Lawrence Berkeley National Laboratory
Awards & Recognition
- Camille & Henry Dreyfus New Faculty Award 2006
- Raymond Andrew Prize (Ampere Society) 2005
- Wang, Y., Ragavan, M., and Hilty, C. Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase. J. Biomol. NMR: 41-48 (2016)
- Chen, C.H., Shih, W.C. and Hilty, C. In-Situ Determination of Tacticity, Deactivation and Kinetics in [rac-(C2H4(1-indenyl)2)ZrMe][B(C6F5)4]and [(Cp)2ZrMe][B(C6F5)4]-Catalyzed Polymerization of 1-Hexene using 13C Hyperpolarized NMR. J. Am. Chem. Soc. 137(21): 6965-6971(2015).
- Kim, Y. and Hilty, C. Affinity Screening Using Competitive Binding with Fluorine-19 Hyperpolarized Ligands. Angew. Chem. Int. Ed. 54(16): 4941-4944 (2015).
- Chen, H.Y., Ragavan, M., and Hilty, C. Protein Folding Studied by Dissolution Dynamic Nuclear Polarization. Angew. Chem. Int. Edit. 52(35): 9192-9195 (2013).
- Lee, Y., Heo, G.S., Zeng, H., Wooley, K. and Hilty, C. Detection of Living Anionic Species in Polymerization Reaction using Hyperpolarized NMR. J. Am. Chem. Soc. 135(12): 4636-4639 (2013).