Department of Chemistry
A headshot

Christian Hilty
Professor

Other Affiliations
Biotechnology

Contact
Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-862-3099
chilty@chem.tamu.edu

Researcher ID

Current Activities

We are developing and applying Magnetic resonance techniques for the investigation of rapid processes and molecular dynamics. Hyperpolarization of nuclear spins yields unprecedented levels of signal, which enables us to acquire NMR spectra of reactions as they occur, in real time. Applications of these techniques include the fields of enzyme catalysis, reactions in organic chemistry, polymers, and more.

To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments, and investigate the dynamics of hyperpolarized spin systems.

Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants of protein structure and function, including of membrane proteins.

Educational Background

Diploma, 1999, Swiss Federal Institute of Technology (ETH) Zurich

Ph.D., 2004, Swiss Federal Institute of Technology (ETH) Zurich

Postdoctoral Fellow 2004-2006, University of California, Berkeley and Lawrence Berkeley National Laboratory

Awards & Recognition

  • Camille & Henry Dreyfus New Faculty Award 2006
  • Raymond Andrew Prize (Ampere Society) 2005

Selected Publications

  • Wang, Y., Ragavan, M., and Hilty, C. Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase. J. Biomol. NMR: 41-48 (2016)
  • Chen, C.H., Shih, W.C. and Hilty, C. In-Situ Determination of Tacticity, Deactivation and Kinetics in [rac-(C2H4(1-indenyl)2)ZrMe][B(C6F5)4]and [(Cp)2ZrMe][B(C6F5)4]-Catalyzed Polymerization of 1-Hexene using 13C Hyperpolarized NMR. J. Am. Chem. Soc. 137(21): 6965-6971(2015).
  • Kim, Y. and Hilty, C. Affinity Screening Using Competitive Binding with Fluorine-19 Hyperpolarized Ligands. Angew. Chem. Int. Ed. 54(16): 4941-4944 (2015).
  • Chen, H.Y., Ragavan, M., and Hilty, C. Protein Folding Studied by Dissolution Dynamic Nuclear Polarization. Angew. Chem. Int. Edit. 52(35): 9192-9195 (2013).
  • Lee, Y., Heo, G.S., Zeng, H., Wooley, K. and Hilty, C. Detection of Living Anionic Species in Polymerization Reaction using Hyperpolarized NMR. J. Am. Chem. Soc. 135(12): 4636-4639 (2013).