We are developing and applying Magnetic resonance techniques for the investigation of rapid processes and
molecular dynamics. Hyperpolarization of nuclear spins yields unprecedented levels of signal, which enables us
to acquire NMR spectra of reactions as they occur, in real time. Applications of these techniques include the
fields of enzyme catalysis, reactions in organic chemistry, polymers, and more.
To enable the use of hyperpolarization in NMR, we develop new hardware and specially adapted NMR experiments,
and investigate the dynamics of hyperpolarized spin systems.
Hand-in-hand with hyperpolarization, we use modern multi-dimensional NMR for the investigation of basic determinants
of protein structure and function, including of membrane proteins.
Diploma, 1999, Swiss Federal Institute of Technology (ETH) Zurich
Ph.D., 2004, Swiss Federal Institute of Technology (ETH) Zurich
Postdoctoral Fellow 2004-2006, University of California, Berkeley and Lawrence Berkeley National Laboratory
Awards & Recognition
- Camille & Henry Dreyfus New Faculty Award 2006
- Raymond Andrew Prize (Ampere Society) 2005
- Hwang, S., Shao, Q., Williams, H., Hilty, C. and Gao, Y.-Q. Methanol Strengthens Hydrogen Bonds and Weakens Hydrophobic Interactions in Proteins - A Combined Molecular Dynamics and NMR study. Journal of Physical Chemistry B, 115 (20):6653-6660 (2011).
- Hwang, S. and Hilty, C. Folding determinants of disulfide bond forming protein B explored by solution NMR Spectroscopy. Proteins-Structure Function and Bioinformatics 79 (5):1365-1375 (2011).
- Chen, H.-Y., Lee, Y., Bowen, S. andHilty, C. Spontaneous emission of NMR signals in hyperpolarized proton spin systems. Journal of Magnetic Resonance 208 (2): 204-209 (2011).
- Zeng, H., Lee, Y. and Hilty, C. Quantitative rate determination by DNP enhanced NMR of a Diels-Alder reaction. Analytical Chemistry 82 (21): 8897-8902 (2010).
- Hilty, C. and Bowen, S. Applications of dynamic nuclear polarization to the study of reactions and reagents in organic and biomolecular chemistry. Organic and Biomolecular Chemistry 8 (15): 3361-3365 (2010).