Wooley Research Group

Department of Chemistry

Publications

2018

  • Wang, H.; Dong, M.; Khan, S.; Su, L.; Li, R.; Song, Y.; Lin, Y.-N.; Kang, N.; Komatsu, C. H.; Elsabahy, M.; Wooley, K. L. "Acid-triggered polymer backbone degradation and disassembly to achieve release of camptothecin from functional polyphosphoramidate nanoparticles" ACS Macro Lett., 2018, 7, 783-788, DOI: 10.1021/acsmacrolett.8b00377.


  • Elsabahy, M.; Wooley, K. L. "Reassessment of Nanomaterials Immunotoxicity", Nano Today, 2018, 20, 10-12, DOI: 10.1016/j.nantod.2018.01.002.


  • Cho, S.; Heo, G. S.; Khan, S.; Huang, J.; Hunstad, D. A.; Elsabahy, M.; Wooley, K. L. "A Vinyl Ether-Functional Polycarbonate as a Template for Multiple Post-polymerization Modifications" Macromolecules, 2018, 51(9), 3233-3242, DOI: 10.1021/acs.macromol.8b00047.


  • Shah, P. N.; Shah, K. N.; Smolen, J. A.; Tagaev, J. A.; Torrealba, J.; Zhou, L.; Zhang, S.; Zhang, F.; Wagers, P. O.; Panzner, M. J.; Youngs, W. J.; Wooley, K. L.; Cannon, C. L. "A novel in vitro metric predicts in vivo efficacy of inhaled silver-based antimicrobials in a murine Pseudomonas aeruginosa pneumonia model" Sci. Rep., 2018, 8, 6376, DOI: 10.1038/s41598-018-24200-w.


  • Borguet, Y. P.; Kahn, S.; Noel, A.; Gunsten, S. P.; Brody, S. L.; Elsabahy, M.; Wooley, K. L. "Development of fully degradable phosphonium-functionalized amphiphilic diblock copolymers for nucleic acids delivery", Biomacromolecules, 2018, 19 (4), 1212-1222, DOI: 10.1021/acs.biomac.8b00069.


  • Felder, S. E.; Redding, M. J.; Noel, A.; Grayson, S. M.; Wooley, K. L. "Organocatalyzed ROP of a Glucopyranoside Derived Five-Membered Cyclic Carbonate", Macromolecules, 2018, 51, 1787-1797, DOI: 10.1021/acs.macromol.7b01785.


  • Su, L.; Li, R.; Khan, S.; Clanton, R.; Zhang, F.; Lin, Y.-N.; Song, Y.; Wang, H.; Fan, J.; Hernandez, S.; Butters, A. S.; Akabani, G.; MacLoughlin, R.; Smolen, J.; Wooley, K. L. "Chemical Design of Both a Glutathione-Sensitive Dimeric Drug Guest and a Glucose-Derived Nanocarrier Host to Achieve Enhanced Osteosarcoma Lung Metastatic Anticancer Selectivity", J. Am. Chem. Soc., 2018, 140, 1438-1446, DOI: 10.1021/jacs.7b11462.


  • Tsao, Y.-Y. T.; Smith, T. H.; Wooley, K. L. "Regioisomeric Preference in Ring-Opening Polymerization of 3’,5’-Cyclic Phosphoesters of Functional Thymidine DNA Analogues", ACS Macro Lett., 2018, 7, 153-158, DOI: 10.1021/acsmacrolett.7b00858.


2017

  • Song, Y.; Chen, Y.; Su, L.; Li, R.; Letteri, R. A.; Wooley, K. L. "Crystallization-driven Assembly of Fully Degradable, Natural Product-based Poly(L-lactide)-block-poly(α-D-glucose carbonate)s in Aqueous Solution", Polymer, 2017, 122, 270-279, DOI: 10.1016/j.polymer.2017.06.065 [A virtual special issue on “Advanced Polymer Synthesis for Functional Nanostructures” in honor of Axel H. E. Müller’s 70th birthday on May 8, 2017].


  • Lonnecker, A. T.; Lim, Y. H.; Wooley, K. L. "A Functional Polycarbonate of a D-Glucal-Derived Bicyclic Carbonate via Organocatalytic Ring-Opening Polymerization", ACS Macro Lett., 2017, 6, 748-753, DOI: 10.1021/acsmacrolett.7b00362.


  • Fan, J.; Li, R.; Wang, H.; He, X.; Nguyen, T. P.; Letteri, R. A.; Zou, J.; Wooley, K. L. "Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs)", Org. Biomol. Chem., 2017, 15, 5145-5154, DOI: 10.1039/C7OB00931C.


  • Tsao, Y.-Y. T.; Wooley, K. L. "Synthetic, Functional Thymidine-derived Polydeoxyribonucleotide-analogs from a 6-Membered Cyclic Phosphoester", J. Am. Chem. Soc., 2017, 139, 5467-5473, DOI: 10.1021/jacs.7b01116. PMCID: PMC5451148.


  • Kristufek, S. L.; Wacker, K. T.; Tsao, Y.-Y.; Su, L.; Wooley, K. L. "Monomer design strategies to create natural product-based polymer materials", Nat. Prod. Rev., 2017, 34, 433-459, DOI: 10.1039/C6NP00112B.


  • Mohamed. N. K.; Hamad, M. A.; Hafez, M. Z. E.; Wooley, K. L.; Elsabahy M. "Nanomedicine in Management of Hepatocellular Carcinoma: Challenges and Opportunities", Int. J. Cancer, 2017, 140, 1475-1484, DOI: 10.1002/ijc.30517.


  • Su, L.; Khan, S.; Fan, J.; Lin, Y.-N.; Wang, H.; Gustafson, T. P.; Zhang, F.; Wooley, K. L. "Functional sugar-based polymers and nanostructures comprised of degradable poly(D-glucose carbonate)s", Polym. Chem., 2017, 8, 1699-1707, DOI: 10.1039/C6PY01978A.


  • Wang, H.; Su, L.; Li, R.; Zhang, S.; Fan, J.; Zhang, F.; Nguyen, T. P.; Wooley, K. L. "Polyphosphoramidates that undergo acid-triggered backbone degradation", ACS Macro Lett., 2017, 6, 219-223, DOI: 10.1021/acsmacrolett.6b00966.


  • Elzeny, H.; Zhang, F.; Ali, E. N.; Fathi, H. A.; Zhang, S.; Li, R.; El-Mokhtar, M. A.; Hamad, M. A.; Wooley, K. L.; Elsabahy, M. "Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA", Drug Des. Devel. Ther., 2017, 11, 483-496, DOI: 10.2147/DDDT.S128503.

2016

  • Zigmond, J. S.; Wooley, K. L. “Amphiphilic Crosslinked Liquid Crystalline Fluoropolymer-Poly(ethylene glycol) Coatings for Application in Challenging Conditions: Comparative study between different liquid crystalline comonomers and polymer architectures”, ACS Appl. Mater. Interfaces, DOI 10.1021/acsami.6b11112.

  • Flores, J. A.; Jahnke, A. A.; Cheng, Z.; Wooley, K. L. “Magnetically-active Pickering Emulsions Stabilized by Hybrid Inorganic/Organic Networks”, Soft Matter, 2016, 12(46), 9342-9354, DOI: 10.1039/C6SM01830K.

  • Yang, G.; Kristufek, S. L.; Link, L. A.; Wooley, K. L.; Robertson, M. L. “Thiol-ene elastomers derived from biobased phenolic acids with varying functionality”, Macromolecules, 2016, 49(20), 7737-7748, DOI: 10.1021/acs.macromol.6b01018.

  • Lonnecker, A. T.; Lim, Y. H.; Felder, S. E.; Besset, C. J.; Wooley, K. L. “Four Different Regioisomeric Polycarbonates Derived from One Natural Product, ?-Glucose”, Macromolecules, 2016, 49(20), 7857-7867, DOI: 10.1021/acs.macromol.6b00591.

  • Wacker, K. T.; Kristufek, S. L.; Lim, S.-M.; Kahn, S.; Wooley, K. L. “Bio-based Polycarbonates Derived from the Neolignan Honokiol”, RSC Advances, 2016, 6(85), 81672-81679, DOI: 10.1039/C6RA19568G.

  • Kristufek, S. L.; Yang, G.; Link, L. A.; Rohde, B. J.; Robertson, M. L.; Wooley, K. L. “Synthesis, Characterization and Cross-linking Strategy of a Quercetin-based Epoxidized Monomer as a Naturally-Derived Replacement for BPA in Epoxy Resins”, Chem. Sus. Chem., 2016, 9(16), 2135-2142, DOI: 10.1002/cssc.201600392.

  • Lim, Y. H.; Tiemann, K. M.; Hunstad, D. A.; Elsabahy, M.; Wooley, K. L. “Polymeric Nanoparticles in Development for Treatment of Pulmonary Infectious Diseases”, Wiley Interdisciplinary Reviews (WIREs): Nanomed. Nanobiotechnol., 2016, 8(6), 842-871, DOI: 10.1002/wnan.1401. PMCID:

  • Zigmond, J. S.; Pavia-Sanders, A.; Russell, J. D.; Wooley, K. L. “Dynamic Anti-icing Coatings: Complex, amphiphilic hyperbranched fluoropolymer poly(ethylene glycol) crosslinked networks with an integrated liquid crystalline comonomer”, Mater., 2016, 28(15), 5471-5479, DOI: 10.1021/acs.chemmater.6b02013.

  • He, X.; Fan, J.; Zou, J.; Wooley, K. L. “Reversible Photo-patterning of Soft Conductive Materials via Spatially-defined Supramolecular Assembly”, Commun., 2016, 52(54), 8455-8458, DOI: 10.1039/C6CC03579E. PMCID: PMC5043637.

  • Zhao, Y.; Detering, L.; Sultan, D.; Cooper, M.; You, M.; Cho, S.; Meier, S.; Luehmann, H.; Sun, G.; Rettig, M.; Dehdashti, F.; Wooley, K. L.; DiPersio, J.; Liu, Y. “Gold Nanoclusters Doped with 64Cu for CXCR4 Positron Emission Tomography Imaging of Breast Cancer and Metastasis”, ACS Nano, 2016, 10(6), 5959-5970, DOI: 10.1021/acsnano.6b01326.

  • Black, K. C.; Ibricevic, A.; Gunsten, S. P.; Flores, J. A.; Gustafson, T. P.; Raymond, J. E.; Samarajeewa, S.; Shrestha, R.; Felder, S. E.; Cai, T.; Shen, Y.; L?bs, A. K.; Zhegalova, N.; Sultan, D. H.; Berezin, M.; Wooley, K. L.; Liu, Y.; Brody, S. “In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Cerenkov imaging”, Biomaterials, 2016, 98, 53-63, DOI: 10.1016/j.biomaterials.2016.04.040. PMCID: PMC489910.

  • Kristufek, T. S.; Kristufek, S. L.; Link, L. A.; Weems, A. C.; Lonnecker, A. T.; Raymond, J. E.; Maitland, D. J.; Wooley, K. L. “Rapidly-cured Isosorbide Natural Product-based Cross-linked Polycarbonate Elastomers”, Chem., 2016, 7(15), 2639-2644, DOI: 10.1039/c5py01659b.

  • He, X.; Fan, J.; Wooley, K. L. “Stimuli-triggered Sol-Gel Transitions of Polypeptide Gels Derived from N-carboxyanhydride (NCA) Polymerizations”, Asian J., 2016, 11(4), 437–447, DOI: 10.1002/asia.201500957.

  • Zigmond, J. S.; Pollack, K. A.; Smedley, S.; Raymond, J. E.; Link, L. A.; Pavia-Sanders, A.; Hickner, M. A.; Wooley, K. L. “Investigation of Intricate, Amphiphilic Crosslinked Hyperbranched Fluoropolymers as Anti-icing Coatings for Extreme Environments”, Polym. Sci., Part A: Polym. Chem., 2016, 54(2), 238–244, DOI: 10.1002/pola.27800.

2015

  • Noel, A.; Borguet, Y. P.; Wooley, K. L. “Self-reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources”, ACS Macro Lett.2015,4(6), 645-650, DOI:  10.1021/acsmacrolett.5b00227. PMCID:  PMC4477896.

  • Flores, J. A.; Pavia-Sanders, A.; Chen, Y.; Pochan, D. J.; Wooley, K. L. “Recyclable Hybrid Inorganic/Organic Magnetically-active Networks for the Sequestration of Crude Oil from Aqueous Environments”,  Mater.201527, 3775-3782, DOI:  10.1021/acs.chemmater.5b01523.

  • Zhang, F.; Zhang, S.; Pollack, S. F.; Li, R.; Gonzalez, A. M.; Fan, J.; Zou, J.; Leininger, S. E.; Pavia-Sanders, A.; Johnson, R.; Nelson, L. D.; Raymond, J. E.; Elsabahy, M.; Hughes, D. M. P.; Lenox, M. W.; Gustafson, T. P.; Wooley, K. L. “Improving Paclitaxel Delivery:  In vitroand in vivo characterization of PEGylated polyphosphoester-based nanocarriers”,  Am. Chem. Soc.2015137, 2056-2066, DOI:  10.1021/ja512616s.

  • Sun, G.; Cho, S.; Yang, F.; He, X.; Pavia-Sanders, A.; Clark, C.; Raymond, J. E.; Verkhoturov, S. V.; Schweikert, E. A.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L. “Advanced Photoresist Technologies by Intricate Molecular Brush Architectures: Diblock brush terpolymer-based positive-tone photoresist materials”,  Polym. Sci., Part A:  Polym. Chem.201553, 193-199, DOI:  10.1002/pola.27362.

  • Yang, F.; Cho, S.; Sun, G.; Verkhoturov, S. V.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L.; Schweikert, E. A. “Nanodomain Analysis with Cluster-SIMS: Application to the characterization of macromolecular brush architecture”, Surface and Interface Analysis, 2015, 47(11), 1051-1055, DOI: 10.1002/sia.5812.

  • Elsabahy, M.; Heo, G. S.; Lim, S.-M.; Sun, G.; Wooley, K. L. “Polymeric Nanostructures for Imaging and Therapy”, Chem. Rev., 2015, 115, 10967-11011, DOI: 10.1021/acs.chemrev.5b00135.

  • Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48(16), 5621-5631, DOI: 10.1021/acs.macromol.5b00752.

  • Wagers, P. O.; Tiemann, K. M.; Shelton, K. L.; Kofron, W. G.; Panzner, M. J.; Wooley, K. L.; Youngs, W. J.; Hunstad, D. A. “Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model”, Antimicrobial Agents and Chemotherapy, 2015, 59(9), 5494-5502, DOI: 10.1128/AAC.00881-15.

  • Weems, A. C.; Raymond, J. E.; Wacker, K. T.; Gustafson, T. P.; Keller, B.; Wooley, K. L.; Maitland, D. J. “Examination of radio-opacity enhancing additives in shape memory polyurethane foams”, J. Appl. Polym. Sci., 2015, 132(33), 42054 (9 pp), DOI: 10.1002/app.42054.

  • Hearon, K.; Wierzbicki, M. A.; Nash, L. D.; Landsman, T. L.; Laramy, C.; Lonnecker, A. T.; Gibbons, M. C.; Ur, S.; Cardinal, K. O.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Processable Shape Memory Polymer System for Biomedical Applications”, Adv. Healthcare Mater., 2015, 4, 1386-1398, DOI: 10.1002/adhm.201500156.

  • Aweda, T. A.; Zhang, S.; Mupanomunda, C.; Burkemper, J.; Heo, G. S.; Bandara, N.; Lin, M.; Cutler, C. S.; Cannon, C. L.; Youngs, W. J.; Wooley, K. L.; Lapi, S. E. “Investigating the pharmacokinectics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer”, J. Labelled Comp Radiopharm., 2015, 58(6), 234-241, DOI: 10.1002/jlcr.3289. PMCID: PMC4457551.

  • Noel, A.; Borguet, Y. P.; Wooley, K. L. “Self-reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources”, ACS Macro Lett., 2015, 4(6), 645-650, DOI: 10.1021/acsmacrolett.5b00227. PMCID: PMC4477896.

  • Elsabahy, M.; Wooley, K. L. “Data Mining as a Guide for the Construction of Biocompatible Nanoparticles via Controlling Polymer Chemistry and Supramolecular Assembly”, Acc. Chem. Res., 2015, 48(6), 1620-1630, DOI: 10.1021/acs.accounts.5b00066. PMCID: PMC4500541.

  • Flores, J. A.; Pavia-Sanders, A.; Chen, Y.; Pochan, D. J.; Wooley, K. L. “Recyclable Hybrid Inorganic/Organic Magnetically-active Networks for the Sequestration of Crude Oil from Aqueous Environments”, Chem. Mater., 2015, 27, 3775-3782, DOI: 10.1021/acs.chemmater.5b01523.

  • Seetho, K.; Zhang, S.; Pollack, K. A.; Zou, J.; Raymond, J. E.; Wooley, K. L. “Facile Synthesis of a Phosphorylcholine-based Zwitterionic Amphiphilic Copolymer for Anti-Biofouling Coatings”, ACS Macro Lett., 2015, 4, 505-510, DOI: 10.1021/mz500818c.

  • Lim, Y. H.; Tiemann, K. M.; Heo, G. S.; Wagers, P. O.; Rezenom, Y. H.; Zhang, S.; Zhang, F.; Youngs, W. J.; Hunstad, D. A.; Wooley, K. L. “Preparation and in vitro Antimicrobial Activity of Silver-bearing Degradable Polymeric Nanoparticles of Polyphosphoester-block-Poly(L-lactide)”, ACS Nano, 2015, 9(2), 1995-2008, DOI: 10.1021/nn507046h.

  • Zhang, F.; Zhang, S.; Pollack, S. F.; Li, R.; Gonzalez, A. M.; Fan, J.; Zou, J.; Leininger, S. E.; Pavia-Sanders, A.; Johnson, R.; Nelson, L. D.; Raymond, J. E.; Elsabahy, M.; Hughes, D. M. P.; Lenox, M. W.; Gustafson, T. P.; Wooley, K. L. “Improving Paclitaxel Delivery: In vitro and in vivo characterization of PEGylated polyphosphoester-based nanocarriers”, J. Am. Chem. Soc., 2015, 137, 2056-2066, DOI: 10.1021/ja512616s.

  • Zhang, F.; Smolen, J. A.; Zhang, S.; Li, R.; Shah, P. N.; Cho, S.; Wang, H.; Raymond, J. E.; Cannon, C. L.; Wooley, K. L. “Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections”, Nanoscale, 2015, 7, 2265-2270, DOI: 10.1039/c4nr07103d.

  • Sun, G.; Cho, S.; Yang, F.; He, X.; Pavia-Sanders, A.; Clark, C.; Raymond, J. E.; Verkhoturov, S. V.; Schweikert, E. A.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L. “Advanced Photoresist Technologies by Intricate Molecular Brush Architectures: Diblock brush terpolymer-based positive-tone photoresist materials”, J. Polym. Sci., Part A:  Polym. Chem., 2015, 53, 193-199, DOI: 10.1002/pola.27362.

2014

  • Pollack, K. A.; Imbesi, P. M.; Raymond, J. E.; Wooley, K. L. “Hyperbranched Fluoropolymer-Polydimethylsiloxane-Poly(ethylene glycol) Crosslinked Terpolymer Networks Designed for Marine and Biomedical Applications:  Heterogeneous non-toxic anti-biofouling surfaces”, ACS Appl. Mater. Interfaces, 2014, 6, 19265-19274, DOI: 10.1021/am505296n.

  • Noel, A.; Borguet, Y. P.; Raymond, J. E.; Wooley, K. L. “Poly(ferulic acid-co-tyrosine):  Effect of the regiochemistry on the photophysical and physical properties, en route to biomedical applications”, Macromolecules, 2014, 47(20), 7109-7117, DOI: 10.1021/ma5015534. PMCID: PMC4211680.

  • Link, L. A.; Lonnecker, A. T.; Hearon, K.; Raymond, J. E.; Maitland, D. J.; Wooley, K. L. “Photo-crosslinked Poly(thioether-co-carbonate) Networks Derived from the Natural Product Quinic Acid”, ACS Appl. Mater. Interfaces, 2014, 6, 17370-17375, DOI: 10.1021/am506087e.

  • He, X.; Fan, J.; Zhang, F.; Li, R.; Pollack, K. A.; Raymond, J. E.; Zou, J.; Wooley, K. L. “Multi-responsive Hydrogels Derived from the Self-assembly of Tethered Allyl-functionalized Racemic Oligopeptides”, J. Mater. Chem. B, 2014, 2(46), 8123-8130, DOI: 10.1039/C4TB00909F. PMCID: PMC4255538.

  • Elsabahy, M.; Wooley, K. L. “Core-shell Nanoparticles for Biomedical Applications.” Handbook of Nanobiomedical Research: Fundamentals, Applications and Recent Developments Volume 1: Materials for Nanomedicine. Vol. 3. Ed. V. Torchilin. Singapore: WorldScientificOpen, 2014. 475-517. Print.

  • Lim, Y. H.; Heo, G. S.; Rezenom, Y. H.; Pollack, S.; Raymond, J. E.; Elsabahy, M.; Wooley, K. L. “Development of a Vinyl Ether-functionalized Polyphosphoester as a Template for Multiple Post-polymerization Conjugation Chemistries and Study of Core Degradable Polymeric Nanoparticles”, Macromolecules, 2014, 47, 4634-4644, DOI: 10.1021/ma402480a.

  • Zou, J.; He, X.; Fan, J.; Raymond, J. E.; Wooley, K. L. “Supramolecularly-knitted Tethered Oligopeptide/Single-walled Carbon Nanotube Organogels”, Chem. Eur. J., 2014, 20, 8842-8847, DOI: 10.1002/chem.201403027. PMCID: PMC4139973.

  • Fan, J.; Li, R.; He, X.; Seetho, K.; Zou, J.; Wooley, K. L. “Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer”, Polym. Chem., 2014, 5, 3977-3987, DOI: 10.1039/C4PY00628C. PMCID: PMC4084918.

  • Noel, A.; Borguet, Y. P.; Raymond, J. E.; Wooley, K. L. “Poly(carbonate-amide)s derived from bio-based resources:  Poly(ferulic acid-co-tyrosine)”, Macromolecules, 2014, 47, 2974-2983, DOI: 10.1021/ma500454f. PMCID: PMC4020594.

  • Heo, G. S.; Cho, S.; Wooley, K. L. “Aldehyde-Functional Polycarbonates as Reactive Platforms”, Polym. Chem., 2014, 5, 3555-3558, DOI: 10.1039/c4py00456f.

  • Hearon, K.; Nash, L. D.; Rodriguez, J. N.; Lonnecker, A. T.; Raymond, J. E.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A High-Performance Recycling Solution for Polystyrene Achieved by the Synthesis of Renewable Poly(thioether) Networks Derived from D-Limonene”, Adv. Mater., 2014, 26(10), 1552-1558, DOI: 10.1002/adma.201304370. PMCID: PMC4000729.

  • Gustafson, T. P.; Lim, Y. H.; Flores, J. A.; Heo, G. S.; Zhang, F.; Zhang, S.; Samarajeewa, S.; Raymond, J. E.; Wooley, K. L. “Holistic assessment of covalently-labelled core-shell polymeric nanoparticles with fluorescent contrast agents towards theranostic applications”, Langmuir, 2014, 30(9), 631-641, DOI: 10.1021/la403943w. PMCID: PMC3933954.

  • Zou, J.; Zhang, F.; Zhang, S.; Pollack, S. F.; Elsabahy, M.; Fan, J.; Wooley, K. L. “Poly(ethylene oxide)-block-polyphosphoester-graft-paclitaxel Conjugates with Acid-labile Linkages as a pH-Sensitive and Functional Nanoscopic Platform for Paclitaxel Delivery”, Adv. Healthcare Mater., 2014, 3(3), 441-448, DOI: 10.1002/adhm.201300235. PMCID: PMC3938983.

  • Cho, S.; Yang, F.; Sun, G.; Eller, M. J.; Clark, C.; Schweikert, E. A.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L. “Directing Self-assembly of Nanoscopic Cylindrical Diblock Brush Terpolymers into Films with Desired Spatial Orientations: Expansion of chemical composition scope”, Macromol. Rapid Commun., 2014, 35(4), 437-441, DOI: 10.1002/marc.201300845.

  • Fan, J.; Zou, J.; He, X.; Zhang, F.; Zhang, S.; Raymond, J. E.; Wooley, K. L. “Tunable mechano-responsive organogels by ring-opening copolymerizations of N-carboxyanhydrides”, Chem. Sci., 2014, 5, 141-150, DOI: 10.1039/c3sc52504j. PMCID: PMC3865608.

  • Samarajeewa, S.; Zentay, R. P.; Jhurry, N. D.; Li, A.; Seetho, K.; Zou, J.; Wooley, K. L. “Programmed Hydrolysis of Nanoassemblies by Electrostatic Interaction-mediated Enzymatic-degradation”, Chem. Commun., 2014, 50(8), 968-970, DOI: 10.1039/c3cc46013d.

  • Zhao, Y.; Sultan, D.; Detering, L.; Cho, S.; Sun, G.; Pierce, R.; Wooley, K. L.; Liu, Y. “Positron Emitter Alloyed Gold Nanoparticle for Cancer Imaging: Improved Radiolabel Stability and Diagnostic Accuracy”, Angew. Chem., 2014, 53, 156-159, DOI: 10.1002/anie.201308494.

2013

  • Trefonas, P.; Thackeray, J. W.; Sun, G.; Cho, S.; Clark, C.; Verkhoturov, S. V.; Eller, M. J.; Li, A.; Pavia-Jimenez, A.; Schweikert, E. A.; Wooley, K. L. “Bottom-up/Top-down High Resolution, High Throughput Lithography using Vertically Assembled Block Bottle Brush Polymers”, SPIE Proceedings, 2013, paper 8682-37.

  • Hearon, K.; Besset, C. J.; Lonnecker, A. T.; Ware, T.; Voit, W. E.; Wilson, T. S.; Wooley, K. L.; Maitland, D. J. “A Structural Approach to Establishing a Platform Chemistry for the Tunable, Bulk Electron Beam Crosslinking of Shape Memory Polymer Systems”, Macromolecules, 2013, 46(22), 8905-8916, DOI: 10.1021/ma4018372.

  • Elsabahy, M.; Li, A.; Sultan, D.; Liu, Y.; Wooley, K. L. “Differential immunotoxicities of poly(ethylene glycol)- vs. poly(carboxybetaine)-coated nanoparticles”, J. Controlled Release, 2013, 172(3), 641-652, DOI: 10.1016/j.conrel.2013.09.010. PMCID: PMC3858532.

  • Ibricevic, A.; Gunsten, S. P.; Zhang, K.; Shrestha, R.; Liu, Y.; Sun, J. Y.; Welch, M. J.; Taylor, J. S.; Wooley, K. L.; Brody, S. L. “PEGylation of Cationic, Shell Crosslinked Knedel-like Nanoparticles Modulates Inflammation and Enhances Cellular Uptake in the Lung”, Nanomedicine:  Nanotechnology, Biology and Medicine, 2013, 9(7), 912-922, DOI: 10.1016/j.nano.2013.02.006. PMCID: PMC3724762.

  • Trefonas, P.; Thackeray, J. W.; Sun, G.; Cho, S.; Clark, C.; Verkhoturov, S. V.; Eller, M. J.; Li, A.; Pavia-Jimenez, A.; Schweikert, E. A.; Wooley, K. L. “Bottom-up/Top-down High-resolution, High-throughput Lithography using Vertically Assembled Block Bottle Brush Polymers”, J. Micro/Nanolith. MEMS MOEMS., 2013, 12 (4), 043006 (December 16, 2013);  DOI: 10.1117/1.jmm.12.4.043006.

  • Elsabahy, M.; Zhang, S.; Zhang, F.; Deng, Z. J.; Lim, Y. H.; Wang, H.; Parsamian, P.; Hammond, P. T.; Wooley, K. L. “Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles”, Scientific Reports, 2013, 3 : 3313, 1-10, DOI: 10.1038/srep03313. PMCID: PMC3837308.

  • Shen, Y.; Zhang, S.; Zhang, F.; Loftis, A.; Pavia-Sanders, A.; Zou, J.; Fan, J.; Taylor, J.-S. A.; Wooley, K. L. “Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors”, Adv. Mater., 2013, 25, 5609-5614, DOI: 10.1002/adma.201302842.

  • Pavía-Sanders, A.; Zhang, S.; Flores, J. A.; Sanders, J. E.; Raymond, J. E.; Wooley, K. L. “Robust Magnetic/Polymer Hybrid Nanoparticles Designed for Crude Oil Entrapment and Recovery in Aqueous Environments”, ACS Nano, 2013, 7(9), 7552-7561, DOI: 10.1021/nn401541e.

  • Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Disk-Cylinder and Disk-Sphere Nanoparticles from Block Copolymer Blend Solution Construction”, Nature Communications, 2013, 4:2297, DOI: 10.1038/ncomms3297.

  • Lim, Y. H.; Heo, G. S.; Cho, S.; Wooley, K. L. “Construction of a Reactive Diblock Copolymer, Polyphosphoester-block-Poly(L-lactide), as a Versatile Framework for Functional Materials that are Capable of Full Degradation and Nanoscopic Assembly Formation”, ACS Macro Lett., 2013, 2(9), 785-789, DOI: 10.1021/mz400229m. PMCID: PMC3808001.

  • Gustafson, T. P.; Lonnecker, A. T.; Heo, G. S.; Zhang, S.; Dove, A. P.; Wooley, K. L. “Poly(?-glucose carbonate) Block Copolymers:  A platform for natural product-based nanomaterials with solvothermatic characteristics”, Biomacromolecules, 2013, 14(9), 3346-3353, DOI: 10.1021/bm4010832.

  • Elsabahy, M.; Samarajeewa, S.; Raymond, J. E.; Clark, C.; Wooley, K. L. “Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their non-crosslinked analogs”, J. Mater. Chem. B, 2013, 1(39), 5241-5255, DOI: 10.1039/c3tb20668h. PMCID: PMC3811931.

  • Shen, Y.; Fang, H.; Zhang, K.; Shrestha, R.; Wooley, K. L.; Taylor, J.-S. A. “Efficient Protection and Transfection of siRNA by Cationic Shell Crosslinked Knedel-like Nanoparticles (cSCKs)”, Nucleic Acid Therapeutics, 2013, 23(2), 95-108, DOI: 10.1089/nat.2012.0390. PMCID: PMC3619153.

  • Wang, Z.; Zhang, K.; Shen, Y.; Smith, J.; Bloch, S.; Achilefu, S.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA Expression Levels in Living Cells with PNA DNA Binary FRET Probes Delivered by Cationic Shell Crosslinked Nanoparticles”, Organic and Biomolecular Chemistry, 2013, 11(19), 3159-3167, DOI: 10.1039/c3ob26923j. PMCID: PMC3619153.

  • Zhang, S.; Wang, H.; Shen, Y.; Zhang, F.; Seetho, K.; Zou, J.; Taylor, J.-S. A.; Dove, A. P.; Wooley, K. L. “A Simple and Efficient Synthesis of an Acid-labile Polyphosphoramidate by Organobase-catalyzed Ring-opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment”, Macromolecules, 2013, 46(13), 5141-5149, DOI: 10.1021/ma400675m. PMCID: PMC3755629.

  • Lee, Y.-J. C.; Wu, B.; Raymond, J. E.; Zeng, Y.; Fang, X.; Wooley, K. L.; Liu, W. R. “A Genetically Encoded Acrylamide Functionality”, ACS Chem. Biol., 2013, 8(8), 1664-1670, DOI: 10.1021/cb400267m. PMCID: PMC3746000.

  • Shah, P. N.; Lin, L. Y.; Smolen, J. A.; Tagaev, J. A.; Gunsten, S. P.; Han, D. S.; Heo, G. S.; Li, Y.; Zhang, F.; Zhang, S.; Wright, B. D.; Panzner, M. J.; Youngs, W. J.; Brody, S. L.; Wooley, K. L.; Cannon, C. L. “Synthesis, Characterization, and in vivo Efficacy of Shell Crosslinked Nanoparticle Formulations Carrying Silver Antimicrobials as Aerosolized Therapeutics”, ACS Nano, 2013, 7(6), 4977-4987, DOI: 10.1021/nn400322f.

  • Mikami, K.; Lonnecker, A. T.; Gustafson, T. P.; Zinnel, N. F.; Pai, P.-J.; Russell, D. H.; Wooley, K. L. “Polycarbonates Derived from Glucose via an Organocatalytic Approach”, J. Am. Chem. Soc., 2013, 135(18), 6826-6829, DOI: 10.1021/ja402319m.

  • Zou, J.; Zhang, F.; Zhang, S.; Fan, J.; Raymond, J. E.; Zhu, J.; Li, A.; Seetho, K.; Pochan, D. J.; Wooley, K. L. “Responsive organogels formed by supramolecular self assembly of PEG-block-allyl-functionalized polypeptides into ß-sheet-driven polymeric ribbons”, Soft Matter, 2013, 9(25), 5951-5958, DOI: 10.1039/c3sm50582k.

  • Zou, J.; Fan, J.; He, X.; Zhang, S.; Wang, H.; Wooley, K. L. “A Facile Glovebox-free Strategy to Significantly Accelerate the Syntheses of Well-defined Polypeptides by N-Carboxyanhydride (NCA) Ring Opening Polymerizations”, Macromolecules, 2013, 46(10), 4223-4226, DOI: 10.1021/ma4007939. PMCID: PMC3686519.

  • Elsabahy, M.; Shrestha, R.; Taylor, S.; Leonard, J.; Wooley, K. L. “Multifunctional Hierarchically-assembled Nanostructures as Complex Stage-wise Dual-delivery Systems for Coincidental Yet Differential Trafficking of siRNA and Paclitaxel”, Nano Lett., 2013, 13(5), 2172-2181, DOI: 10.1021/nl4006645. PMCID: PMC3681414.

  • Elsabahy, M.; Wooley, K. L. “Cytokines as Biomarkers of Nanoparticle Immunotoxicity”, Chem. Soc. Rev., 2013, 42(12), 5552-5576, DOI: 10.1039/c3cs60064e. PMCID: PMC3665642.

  • Zhang, S.; Zou, J.; Elsabahy, M.; Karwa, A.; Li, A.; Moore, D. A.; Dorshow, R. B.; Wooley, K. L. “Poly(ethylene oxide)-block-polyphosphester-based Paclitaxel Conjugates as a Platform for Ultra-high Paclitaxel-loaded Multifunctional Nanoparticles”, Chem. Sci., 2013, 4, 2122-2126, DOI: 10.1039/c3sc50252j.

  • Shen, Y.; Shrestha, R.; Ibricevic, A.; Gunsten, S. P.; Welch, M. J.; Wooley, K. L.; Brody, S. L.; Taylor, J.-S. A.; Liu, Y. “Antisense PNA Functionalized Cationic Nanocomplex for in vivo mRNA Detection”, Interface Focus, 2013, 3, 20120059, DOI: 10.1098/rsfs.2012.0059. PMCID: PMC3638413.

  • Samarajeewa, S.; Ibricevic, A.; Gunsten, S. P.; Shrestha, R.; Elsabahy, M.; Brody, S. L.; Wooley, K. L. “Degradable Cationic Shell Crosslinked Knedel-like Nanoparticles:  Synthesis, degradation, nucleic acid binding and in vitro evaluation”, Biomacromolecules, 2013, 14(4), 1018-1027, DOI: 10.1021/bm3018774. PMCID: PMC3640429.

  • Lee, Y.; Heo, G. S.; Zeng, H.; Wooley, K. L.; Hilty, C. “Detection of Living Anionic Species in Polymerization Reaction Using Hyperpolarized NMR”, J. Am. Chem. Soc., 2013, 135(12), 4636-4639, DOI: 10.1021/ja4001008.

  • Sun, G.; Cho, S.; Clark, C.; Verkhoturov, S.; Eller, M. J.; Li, A.; Pavia-Jiménez, A.; Schweikert, E. A.; Thackeray, J. W.; Trefonas, P.; Wooley, K. L. “Nanoscopic Cylindrical Dual Concentric and Lengthwise Block Brush Terpolymers as Covalent Pre-assembled High Resolution and High Sensitivity Negative-tone Photoresist Materials”, J. Am. Chem. Soc., 2013, 135(11), 4203-4206, DOI: 10.1021/ja3126382.

  • Zhang, F.; Elsabahy, M.; Zhang, S.; Lin, L. Y.; Zou, J.; Wooley, K. L. “Shell Crosslinked Knedel-like Nanoparticles for Delivery of Cisplatin:  Effects of crosslinking”, Nanoscale, 2013, 5(8), 3220-3225, DOI: 10.1039/c3nr34320k.

  • Samarajeewa, S.; Shrestha, R.; Elsabahy, M.; Karwa, A.; Li, A.; Zentay, R. P.; Kostelc, J. G.; Dorshow, R. B.; Wooley, K. L. “In vitro Efficacy of Paclitaxel-loaded Dual-responsive Shell Crosslinked Polymer Nanoparticles Having Orthogonally-degradable Disulfide Crosslinked Corona and Polyester Core Domains”, Molecular Pharmaceutics, 2013, 10(3), 1092-1099, DOI: 10.1021/mp3005897.

  • Zhu, J.; Zhang, S.; Zhang, F.; Wooley, K. L.; Pochan, D. J. “Hierarchical Assembly of Complex Block Copolymer Nanoparticles into Multicompartment Superstructures through Tunable Interparticle Associations”, Adv. Func. Mater., 2013, 23(14), 1767-1773, DOI: 10.1002/adfm.201202323.

Patents

  • "Degradable Polycarbonate Sport Fishing Materials", Wooley, Karen L.; Felder, Simcha E.; Versaw, Brooke A.; Jahnke, Ashlee A.; Link, Lauren A.; Wooley, Mark W.; Hinton, Charles A.; Howell, Jr., William R.; U.S. Provisional Patent Application Serial No. 62/362,885, filed July 15, 2016; U.S. Patent Application Serial No. 15/650,244, filed July 14, 2017; PCT International Application Serial No. PCT/US2017/042061, filed July 14, 2017.

  • "Functional, Cross-Linked Nanostructures For Tandem Optical Imaging and Therapy", Neumann, William L.; Dorshow, Richard B., Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Lily Y.; Sun, Guorong; U.S. Patent Application Serial No. 13/697,149, filed November 17, 2011; WO 2011143524, filed November 17, 2011; PCT International Application Serial No. PCT/US2011/036392, filed December 13, 2012; Prior Publication Data: US 2013/0137976 A1, May 30, 2013; U.S. Patent Number 9,295,650, issued March 29, 2016.

  • "Ternary Antifouling Compositions and Methods", Wooley, Karen L.; Raymond, Jeffery E.; Pollack, Kevin A; Imbesi, Philip M; ; U.S. Patent Application Serial No. 14/575,625, filed December 18, 2014; WO 2013192529; Prior Publication Data: US 2015/0307720 A1, October 29, 2015; U.S. Patent Number 9,422,433 issued August 23, 2016.

  • "Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same", Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 14/020,371, filed September 6, 2013; Prior Publication Data: US 2015/0072292 A1, March 12, 2015; U.S. Patent Number 9,405,189 issued August 2, 2016.

  • "Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same", Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 14/020,343, filed September 6, 2013; Prior Publication Data: US 2015/0072291, filed March 12, 2015.

  • "Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same", Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,019, filed November 19, 2012; Prior Publication Data: US 2014/0141376 A1, May 22, 2014; U.S. Patent Number 8,822,130 issued September 2, 2014.

  • "Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same", Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,026, filed November 19, 2012; Prior Publication Data: US 2014/0141375 A1, May 22, 2014; U.S. Patent Number 9,223,214 issued December 29, 2015.

  • "Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same", Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; Full Appl. Serial Number 13/681,012, filed November 19, 2012; Prior Publication Data: US 2014/0142252, May 22, 2014.

  • "Self-Assembled Structures, Method of Manufacture Thereof and Articles Comprising The Same", Cho, Sangho; Sun, Guorong; Wooley, Karen L.; Thackeray, James W.; Trefonas, III, Peter; U.S. Patent Application Serial No. 13/681,002, filed November 19, 2012; Prior Publication Data: US 2014/0142249 A1, May 22, 2014; U.S. Patent Number 9,447,220 issued September 20, 2016.

  • "Polymer-Drug Systems", Wooley, Karen L.; Zou, Jiong; El Sabahy, Mahmoud; Zhang, Shiyi; Zhang, Fuwu; U.S. Patent Number 9,545,447 issued January 17, 2017.

  • "Brush Copolymers", Cheng, Chong; Khoshdel, Ezat; Wooley, Karen L.; Patent WO 2008/064972, U.S. Patent Number 7,960,479 issued June 14, 2011.

  • "Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH", Wooley, Karen L.; Dorshow, Richard B.; Freskos, John N.; Neumann, William L.; Shieh, Jeng J.; Lee, Nam S.; Lin, Yun; Sun, Guorong; PCT Int. Appl. US2011/036411 Filed May 13, 2011; Int. Pub. No. WO 2011/143540 A1 Int. Pub. Date November 17, 2011. Based upon U.S. Provisional Appl. No. 61/334,723 Filed May 14, 2010. Published December 03, 2015. WO 2011/143540 A1.

  • "Degradable Polycarbonates", Wooley, Karen L; Besset, Celine J.; Lonnecker, Alexander T; Streff, Jennifer M.; Kristufek, Samantha L.; Hearon, Michael K.; New International (PCT) Patent PCT/US2011/056204; WO 2012/051448 A1; Filed October 13, 2011. Based on U.S. Provisional Appl. No. 61/392,893; filed October 13, 2010.

  • "Composition Comprising Brush Copolymer For Treating Hair", Burry, Jason Shaun; Cheng, Chong; Evans, Richard Livesey; Khoshdel, Ezat; Wooley, Karen Lynn; Patent WO 2008/064973; granted August 2010.

  • "Photonic Shell-Core Cross Linked and Functionalized Nanostructures for Biological Applications", Neumann, William L.; Rajagopalan, Raghavan; Dorshow, Richard B.; Shieh, J. J.; Wooley, Karen L.; Lee, Nam S.; Appl. Serial Number 60/986171; filed November 7, 2007.

  • "Dendritic-based Macromolecules", Fréchet, Jean M. J.; Hawker, Craig J.; Wooley, Karen L.; U.S. Patent Number 7,101,937 issued September 5, 2006.

  • "Cell-permeable Nanoconjugates of Shell-crosslinked Knedel (SCK) and Peptide Nucleic Acids ("PNAs") with uniquely expressed or over-expressed mRNA-targeting Sequences for Early Diagnosis and Therapy of Cancer", Becker, Matthew L.; Fang, Huafeng; Li, Xiaoxu; Pan, Dipanjan; Rossin, Raffaella; Sun, Xiankai; Taylor, John-Stephen; Turner, Jeffrey L.; Welch, Michael J.; Wooley, Karen L.; WO 2006044716; U.S. Patent Number 8,354,093 issued January 15, 2013.

  • "Particles Comprising Amphiphilic Copolymers, Having a Cross-linked Shell Domain and an Interior Core Domain, Useful for Pharmaceutical and Other Applications", Wooley, K. L.; Thurmond II, K. Bruce; Huang, Haiyong; WO 97/49387, U.S. Patent Number 6,383,500 issued May 7, 2002.

  • "Dendritic-based Macromolecules and Method of Production", Fréchet, Jean M. J.; Hawker, Craig J.; Wooley, Karen L.; Patent WO 9321259, US 92868535.