Publications

    1. Patra S, Barondeau DP. "Mechanism of activation of the human cysteine desulfurase complex by frataxin" Proc Natl Acad Sci USA, 2019, 116 (39), 19421-19430. Read more.
    2. Das D, Patra S, Bridwell-Rabb J, Barondeau DP. "Mechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich's ataxia." Journal of Biological Chemistry, 2019. Read more.
    3. Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP. "Structure of human Fe-S assembly complex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions." Proc Natl Acad Sci USA, 2017, 114 (27), E5325-E5334. Read more.
    4. Vranish JN, Das D, Barondeau DP. "Real-time Kinetic Probes Support Monothiol Glutaredoxins As Intermediate Carriers in Fe-S Cluster Biosynthetic Pathways." ACS Chemical Biology, 2016, 11 (11), 3114-3121. Read more.
    5. Fox NG, Das D, Chakrabarti M, Lindahl PA, Barondeau DP. "Frataxin accelerates [2Fe-2S] cluster formation on the human Fe-S assembly complex." Biochemistry, 2015, 54 (25), 3880-3889. Highlighted article on Biochemistry web page. Read more.
    6. Fox NG, Chakrabarti M, McCormick SP, Lindahl PA, Barondeau DP. "The human iron-sulfur assembly complex catalyzes the synthesis of [2Fe-2S] clusters on ISCU2 that can be transferred to acceptor molecules." Biochemistry, 2015, 54 (25), 3871-3879 Read more.
    7. Vranish JN, Russell WK, Yu LE, Cox RM, Russell DH, Barondeau DP. "Fluorescent probes for tracking the transfer of iron-sulfur cluster and other metal cofactors in biosynthetic reaction pathways." J Am Chem Soc, 2015, 137 (1), 390-398. Read more.
    8. Bridwell-Rabb J, Fox NG, Tsai CL, Winn AM, Barondeau DP. "Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry." Biochemistry, 2014, 53 (30), 4904-4913. Read more.
    9. Meier MM, Rajendran C, Malisi C, Fox NG, Xu C, Schlee S, Barondeau DP, Höcker B, Sterner R, Raushel FM. "Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template." J Am Chem Soc, 2013, 135 (31), 11670-11677. Read more.
    10. Tsai PC, Fox N, Bigley AN, Harvey SP, Barondeau DP, Raushel FM. "Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents." Biochemistry, 2012, 51 (32), 6463-6475. Read more.
    11. Bridwell-Rabb, J., Ianuzzi, C., Pastore, A., Barondeau, D. P. "Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis" Biochemistry, 2012, 51 (12), 2506-2514. Highlighted article on Biochemistry web page. Read More
    12. Bridwell-Rabb, J., Winn, A. M., Barondeau, D. P. "Structure-function analysis of Friedreich's ataxia mutants reveals determinants for frataxin activation of the Fe-S assembly complex" Biochemistry, 2011, 50 (33), 7265-7274. Read More
    13. Tsai, C., Bridwell-Rabb, J., Barondeau, D.P. “Friedreich’s ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex” Biochemistry, 2011, 50 (29), 6478–6487. Read More
    14. Tsai, C. and Barondeau D. P. “Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex” Biochemistry, 2010, 49, 9132-9139 Highlighted article on Biochemistry web page. Read More
    15. Wood, T., Bridwell-Rabb, J., Gao, T., Chang, Y., LiWang, A., Barondeau, D. P., Golden, S. “The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor” Proc Natl Acad Sci USA 2010 107, 5804-5809. Read More.
    16. Cummings, J. A., Nguyen, T.T., Fedorov, A. A., Kolb, P., Xu, C., Fedorov, E. V., Shoichet, B.K., Barondeau, D. P., Almo, S. C., Raushel, F. M. “Structure, Mechanism, and Substrate Profile for Sco3058: The Closest Bacterial Homologue to Human Renal Dipeptidase” Biochemisty 2010 49, 611-622. Read More
    17. Shin, D. S., DiDonato, M., Barondeau, D. P., Hura, G. L., Hitomi, C., Berglund, J. A., Getzoff, E. D., Cary, S. C, and Tainer, J. A. “SOD from a Eukaryotic Thermophile: Structures, Stability, and Mechanism” J. Mol. Biol., 2009 385 1534-1555. Read More
    18. Barondeau, D. P., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “The Case of the Missing Ring: Radical Cleavage of a Carbon-Carbon Bond and Implications for GFP Chromophore Biosynthesis” J. Am. Chem. Soc. 2007, 129, 3118-3126. Read More
    19. Barondeau, D. P., Tainer, J. A., and Getzoff, E. D. “Structural Evidence for an Enolate Intermediate in GFP Fluorophore Biosynthesis” J. Am. Chem. Soc. (Communication) 2006, 128, 3166-3168. Read More
    20. Barondeau, D. P., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “Understanding GFP Post-Translational Chemistry: Structures of Designed Variants that Achieve Backbone Cyclization and Decarboxylation” J. Am. Chem. Soc., 2006, 128, 4685-4693. Read More
    21. Wood, T. I., Barondeau, D. P., Hitomi, C., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “Defining the Role of Arginine 96 in GFP Fluorophore Biosynthesis” Biochemistry, 2005, 44, 16211-16220. Read More
    22. Barondeau, D. P., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “Understanding GFP Chromophore Biosynthesis: Controlling Backbone Cyclization and Modifying Post-translational Chemistry” Biochemistry 2005, 44, 1960-1970. Read More
    23. Barondeau, D. P. and Getzoff, E. D. “Structural Insights into Protein-Metal Ion Partnerships” Current Opinion in Structural Biology 2004, 14, 765-774. Read More
    24. Barondeau, D. P., Kassmann, C. J., Bruns, C. K., Tainer, J. A., and Getzoff, E. D. “Nickel Superoxide Dismutase Structure and Mechanism” Biochemistry 2004, 43, 8038-8047. Read More
    25. Barondeau, D. P., Putnam, C. D., Kassmann, C. J., Tainer, J. A. and Getzoff, E. D. “Mechanism and Energetics of Green Fluorescent Protein Chromophore Synthesis Revealed by Trapped Intermediate Structures” Proc. Natl. Acad. Sci. USA. 2003, 100, 12111-12116. Read More
    26. Barondeau, D. P., Kassmann, C. J., Tainer, J. A. and Getzoff, E. D. "Structural chemistry of a green fluorescent protein Zn biosensor" J. Am. Chem. Soc. (Communication) 2002, 124, 3522-3524. Read More
    27. Barondeau, D. P. and Lindahl, P. A. "Methylation of carbon monoxide dehydrogenase from Clostridium thermoaceticum and the mechanism of acetyl-coenzyme A synthesis." J. Am. Chem. Soc. 1997, 119, 3959-3970. Read More
    28. Barondeau, D. P., Roberts, L. M., Lindahl, P. A. "Stability of the Ni-C state and oxidative titrations of Desulfovibrio gigas hydrogenase monitored by EPR and electronic absorption spectroscopies." J. Am. Chem. Soc. 1994, 116, 3442-3448. Read More