Publications
- Patra S, Barondeau DP. "Mechanism of activation of the human cysteine desulfurase complex by frataxin" Proc Natl Acad Sci USA, 2019, 116 (39), 19421-19430. Read more.
- Das D, Patra S, Bridwell-Rabb J, Barondeau DP. "Mechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich's ataxia." Journal of Biological Chemistry, 2019. Read more.
- Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP. "Structure of human Fe-S assembly complex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions." Proc Natl Acad Sci USA, 2017, 114 (27), E5325-E5334. Read more.
- Vranish JN, Das D, Barondeau DP. "Real-time Kinetic Probes Support Monothiol Glutaredoxins As Intermediate Carriers in Fe-S Cluster Biosynthetic Pathways." ACS Chemical Biology, 2016, 11 (11), 3114-3121. Read more.
- Fox NG, Das D, Chakrabarti M, Lindahl PA, Barondeau DP. "Frataxin accelerates [2Fe-2S] cluster formation on the human Fe-S assembly complex." Biochemistry, 2015, 54 (25), 3880-3889. Highlighted article on Biochemistry web page. Read more.
- Fox NG, Chakrabarti M, McCormick SP, Lindahl PA, Barondeau DP. "The human iron-sulfur assembly complex catalyzes the synthesis of [2Fe-2S] clusters on ISCU2 that can be transferred to acceptor molecules." Biochemistry, 2015, 54 (25), 3871-3879 Read more.
- Vranish JN, Russell WK, Yu LE, Cox RM, Russell DH, Barondeau DP. "Fluorescent probes for tracking the transfer of iron-sulfur cluster and other metal cofactors in biosynthetic reaction pathways." J Am Chem Soc, 2015, 137 (1), 390-398. Read more.
- Bridwell-Rabb J, Fox NG, Tsai CL, Winn AM, Barondeau DP. "Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry." Biochemistry, 2014, 53 (30), 4904-4913. Read more.
- Meier MM, Rajendran C, Malisi C, Fox NG, Xu C, Schlee S, Barondeau DP, Höcker B, Sterner R, Raushel FM. "Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template." J Am Chem Soc, 2013, 135 (31), 11670-11677. Read more.
- Tsai PC, Fox N, Bigley AN, Harvey SP, Barondeau DP, Raushel FM. "Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents." Biochemistry, 2012, 51 (32), 6463-6475. Read more.
- Bridwell-Rabb, J., Ianuzzi, C., Pastore, A., Barondeau, D. P. "Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis" Biochemistry, 2012, 51 (12), 2506-2514. Highlighted article on Biochemistry web page. Read More
- Bridwell-Rabb, J., Winn, A. M., Barondeau, D. P. "Structure-function analysis of Friedreich's ataxia mutants reveals determinants for frataxin activation of the Fe-S assembly complex" Biochemistry, 2011, 50 (33), 7265-7274. Read More
- Tsai, C., Bridwell-Rabb, J., Barondeau, D.P. “Friedreich’s ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex” Biochemistry, 2011, 50 (29), 6478–6487. Read More
- Tsai, C. and Barondeau D. P. “Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex” Biochemistry, 2010, 49, 9132-9139 Highlighted article on Biochemistry web page. Read More
- Wood, T., Bridwell-Rabb, J., Gao, T., Chang, Y., LiWang, A., Barondeau, D. P., Golden, S. “The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor” Proc Natl Acad Sci USA 2010 107, 5804-5809. Read More.
- Cummings, J. A., Nguyen, T.T., Fedorov, A. A., Kolb, P., Xu, C., Fedorov, E. V., Shoichet, B.K., Barondeau, D. P., Almo, S. C., Raushel, F. M. “Structure, Mechanism, and Substrate Profile for Sco3058: The Closest Bacterial Homologue to Human Renal Dipeptidase” Biochemisty 2010 49, 611-622. Read More
- Shin, D. S., DiDonato, M., Barondeau, D. P., Hura, G. L., Hitomi, C., Berglund, J. A., Getzoff, E. D., Cary, S. C, and Tainer, J. A. “SOD from a Eukaryotic Thermophile: Structures, Stability, and Mechanism” J. Mol. Biol., 2009 385 1534-1555. Read More
- Barondeau, D. P., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “The Case of the Missing Ring: Radical Cleavage of a Carbon-Carbon Bond and Implications for GFP Chromophore Biosynthesis” J. Am. Chem. Soc. 2007, 129, 3118-3126. Read More
- Barondeau, D. P., Tainer, J. A., and Getzoff, E. D. “Structural Evidence for an Enolate Intermediate in GFP Fluorophore Biosynthesis” J. Am. Chem. Soc. (Communication) 2006, 128, 3166-3168. Read More
- Barondeau, D. P., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “Understanding GFP Post-Translational Chemistry: Structures of Designed Variants that Achieve Backbone Cyclization and Decarboxylation” J. Am. Chem. Soc., 2006, 128, 4685-4693. Read More
- Wood, T. I., Barondeau, D. P., Hitomi, C., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “Defining the Role of Arginine 96 in GFP Fluorophore Biosynthesis” Biochemistry, 2005, 44, 16211-16220. Read More
- Barondeau, D. P., Kassmann, C. J., Tainer, J. A., and Getzoff, E. D. “Understanding GFP Chromophore Biosynthesis: Controlling Backbone Cyclization and Modifying Post-translational Chemistry” Biochemistry 2005, 44, 1960-1970. Read More
- Barondeau, D. P. and Getzoff, E. D. “Structural Insights into Protein-Metal Ion Partnerships” Current Opinion in Structural Biology 2004, 14, 765-774. Read More
- Barondeau, D. P., Kassmann, C. J., Bruns, C. K., Tainer, J. A., and Getzoff, E. D. “Nickel Superoxide Dismutase Structure and Mechanism” Biochemistry 2004, 43, 8038-8047. Read More
- Barondeau, D. P., Putnam, C. D., Kassmann, C. J., Tainer, J. A. and Getzoff, E. D. “Mechanism and Energetics of Green Fluorescent Protein Chromophore Synthesis Revealed by Trapped Intermediate Structures” Proc. Natl. Acad. Sci. USA. 2003, 100, 12111-12116. Read More
- Barondeau, D. P., Kassmann, C. J., Tainer, J. A. and Getzoff, E. D. "Structural chemistry of a green fluorescent protein Zn biosensor" J. Am. Chem. Soc. (Communication) 2002, 124, 3522-3524. Read More
- Barondeau, D. P. and Lindahl, P. A. "Methylation of carbon monoxide dehydrogenase from Clostridium thermoaceticum and the mechanism of acetyl-coenzyme A synthesis." J. Am. Chem. Soc. 1997, 119, 3959-3970. Read More
- Barondeau, D. P., Roberts, L. M., Lindahl, P. A. "Stability of the Ni-C state and oxidative titrations of Desulfovibrio gigas hydrogenase monitored by EPR and electronic absorption spectroscopies." J. Am. Chem. Soc. 1994, 116, 3442-3448. Read More