Watanabe Research Lab
[1] Kelly, G. T., Washburn, L. A., and Watanabe, C. M. H. (2019) The Fate of Molecular Oxygen in Azinomycin Biosynthesis, J. Org. Chem. 84, 2991-2996.
[2] Gowda, V., Foley, B., Du, J., Esteb, M., and Watanabe, C. M. H. (2018) Biocatalysis with the milk protein β-lactoglobulin: promoting retroaldol cleavage of α,β-unsaturated aldehydes, Org. Biomol. Chem. 16, 2210-2213.
[3] Gowda, V., Foulke-Abel, J., Agbo, H., Bench, B. J., Chae, J., Russell, W. K., and Watanabe, C. M. H. (2017) Lipofuscin Formation Catalyzed by the Milk Protein β-Lactoglobulin: Lysine Residues in Cycloretinal Synthesis, Biochemistry 56, 5715-5719.
[4] Mori, S., Nepal, K. K., Kelly, G. T., Sharma, V., Simkhada, D., Gowda, V., Delgado, D., and Watanabe, C. M. H. (2017) Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents, Biochemistry 56, 805-808.
[5] Mori, S., Simkhada, D., Zhang, H., Erb, M. S., Zhang, Y., Williams, H., Fedoseyenko, D., Russell, W. K., Kim, D., Fleer, N., Ealick, S. E., and Watanabe, C. M. H. (2016) Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG, Biochemistry 55, 704-714.
[6] Mori, S., Williams, H., Cagle, D., Karanovich, K., Horgen, F. D., Smith, R., III, and Watanabe, C. M. H. (2015) Macrolactone nuiapolide, isolated from a hawaiian marine cyanobacterium, exhibits anti-chemotactic activity, Mar. Drugs 13, 6274-6290.
[7] Nepal, K. K., Lee, R. P., Rezenom, Y. H., and Watanabe, C. M. H. (2015) Probing the Role of N-Acetyl-glutamyl 5-Phosphate, an Acyl Phosphate, in the Construction of the Azabicycle Moiety of the Azinomycins, Biochemistry 54, 4415-4418.
[8] Simkhada, D., Zhang, H., Mori, S., Williams, H., and Watanabe, C. M. H. (2013) Activation of cryptic metabolite production through gene disruption: dimethyl furan-2,4-dicarboxylate produced by Streptomyces sahachiroi, Beilstein J. Org. Chem. 9, 1768-1773, 1766 pp.
[9] Foulke-Abel, J., Kelly, G. T., Zhang, H., and Watanabe, C. M. H. (2011) Characterization of AziR, a resistance protein of the DNA cross-linking agent azinomycin B, Mol. BioSyst. 7, 2563-2570.
[10] Foulke-Abel, J., Agbo, H., Zhang, H., Mori, S., and Watanabe, C. M. H. (2011) Mode of action and biosynthesis of the azabicycle-containing natural products azinomycin and ficellomycin, Nat. Prod. Rep. 28, 693-704.
[11] Bench, B. J., Foulke-Abel, J., and Watanabe, C. M. H. (2011) Milk, revealed "silent" chemistry: New mode of cycloretinal synthesis, Mol. BioSyst. 7, 162-168.
[12] Sharma, V., Kelly, G. T., Foulke-Abel, J., and Watanabe, C. M. H. (2009) Aminoacetone as the Penultimate Precursor to the Antitumor Agent Azinomycin A, Org. Lett. 11, 4006-4009.
[13] Sharma, V., Kelly, G. T., and Watanabe, C. M. H. (2008) Exploration of the molecular origin of the azinomycin epoxide: Timing of the biosynthesis revealed, Org. Lett. 10, 4815-4818.
[14] Kim, E. J., Angell, S., Janes, J., and Watanabe, C. M. H. (2008) Estimating P-coverage of biosynthetic pathways in DNA libraries and screening by genetic selection: biotin biosynthesis in the marine microorganism chromohalobacter, Mol. BioSyst. 4, 606-613.
[15] Kelly, G. T., Sharma, V., and Watanabe, C. M. H. (2008) An improved method for culturing Streptomyces sahachiroi: Biosynthetic origin of the enol fragment of azinomycin B, Bioorg. Chem. 36, 4-15.
[16] Liu, C., Kelly, G. T., and Watanabe, C. M. H. (2006) In Vitro Biosynthesis of the Antitumor Agent Azinomycin B, Org. Lett. 8, 1065-1068.
[17] Angell, S., Bench, B. J., Williams, H., and Watanabe, C. M. H. (2006) Pyocyanin isolated from a marine microbial population: Synergistic production between two distinct bacterial species and mode of action, Chem. Biol. (Cambridge, MA, U. S.) 13, 1349-1359.
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Texas A&M University
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Texas A&M University
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College Station, TX 77843-3255