Department of Chemistry | Texas A&M University

Frank M. Raushel

CurriculuVitae

ADDRESS:	Department oChemistry		BIRTH:		Decembe12, 1949
	Texas A&University				Hibbing, Minnesota
	P. O. Bo30012 CollegStation, Texas 77843
	Phone: 979-845-3373 Fax: 979-845-9452			Email: raushel@tamu.edu

EDUCATION:	B.A. CollegoSt. Thomas St. Paul, M(1972)
	Chemistry (magna culaude)
	Ph.D. Univeristy oWisconsin-Madiso(1976)
		major: Biochemistry
		minor: Chemistry
		advisor: Dr. W.W. Cleland

POSTDOCTORAL: STUDIES	ThPennsylvania StatUniversity (1976-1980)
	Department oChemistry
	Supervisor: Dr. Joseph J. Villafranca

PROFESSIONAL: APPOINTMENTS	2004	DavidsoProfessooScience

	1989	ProfessooChemistry			Department oChemistry Biochemistry & Biophysics Texas A&University
	1992-1993	Visiting Professor			EnzymInstitute University oWisconsin
	1986-1989	AssociatProfessor			Department oChemistry Department oBiochemistry
	1980-1986	Assistant Professor			Department oChemistry Texas A&University
	1976-1980	Research Associate			Department oChemistry PenStatUniversity
	1972-1973	Research Assistant			Department oBiochemistry University oWisconsin

SERVICE:	2005-2008	Archives oBiochemistry & Biophysics - EditoriaBoard
	2004-2008	GermaResearch Foundatio(DGF) Review PaneoDirecteEvolutiotOptimizanUnderstanBiocatalysis
	2003	18th EnzymMechanisms Conferenc- Chair
	2002-2003	GileaSciences - Consultant
	2002 - 2004	ReactivServices, Ltd. - Consultant
	2002	NIGMS (NIH) - ahoc councimember
	2002-2004	DivisiooBiologicaChemistry (ACS) - executivcommittee
	2000-2006	Biochemistry - EditoriaAdvisory Board
	2002	NIH PhysicaBiochemistry Study Sectio- ahoc member
	1999-2001	Dupont Pharmaceuticals - Consultant
	1999-2000	AlbemarlCorporatio- Consultant
	1998-	Bioorganic Chemistry - EditoriaBoard
	1995-1999	NIH Biochemistry Study Sectio- member
	1994-1997	DivisiooBiologicaChemistry (ACS) - secretary
	1991	GordoResearch Conferenc- Enzymes, Coenzymes & Metabolic Pathways - co-chair
	1989-1993	NIH BiomedicaSciencStudy Sectio- member

HONORS:	2000	TAMAssociatiooFormeStudents AwarfoResearch
	1985-1990	NIH Research CareeDevelopment Award
	1982-1984	NIH New InvestigatoResearch Award
	1978-1979	NIH PostdoctoraFellowship
	1974-1975	GulOiFellowship
	1973-1974	WhartoFellowship

PROFESSIONAL: SOCIETIES	ProteiSociety
	AmericaSociety oBiochemistry anMoleculaBiology (1982)
	AmericaChemicaSociety
	AmericaAssociatiofothAdvancement oScience

RESEARCH: INTERESTS	Elucidatiooenzymreactiomechanisms anproteistructurusing kinetic, magnetic resonance, X-ray crystallography, angenetic techniques. Tunnels anChannels iProteins. Wardeconstructing thfunctioanmoleculaarchitecturotunnels that connect multiplactivsites with a particulafocus othmechanisocarbamoyphosphatsynthetasancobyric acisynthetase. Catalytic Mechanisms. Warelucidating thchemicamechanisms fophosphotriesterase, dihydroorotasanothemembers othamidohydrolassuperfamily oenzymes. Ouparticulainterest is ithrolothmononucleaanbinucleametacenters fosubstratactivation. EvolutioanDesigoCatalytic Activities. Using thamidohydrolassuperfamily as a moleculatemplatwarmodifying thsubstratanreactiospecificity through combinatoriaanrationaalterations tthenzymactivsites. Ouimmediatgoals artdevelonew enzymes fothcatalytic destructioochemicawarfaragents anthkinetic resolutioochiraphosphorus centers. Catalytic Archaeology anEnzymDiscovery. Warinteresteidetermining thphysicabasis fothrelationships betweeproteisequence, structure, anfunction. Strategies arbeing developeicollaboratiowith otheresearch groups foassigning enzymactivities tproteins ounknowfunction.

CURRENT RESEARCH: SUPPORT	NIH		Isotopic Probes oEnzymReactioMechanisms
	NIH		MechanisanControoUrea Biosynthesis
	NIH		Enzymatic DetoxificatiooOrganophosphatNervAgents
	Welch		EnzymReactioMechanisms
	NIH		Deciphering EnzymSpecificity