List oPublications

2013

Bigley, AN, Xu, C, Henderson, TJ, Harvey, SP, Raushel, F(2013) Enzymatic NeutralizatioothChemicaWarfarAgent VX: EvolutiooPhosphotriesterasfoPhosphorothiolatHydrolysis. J. Am. Chem. Soc. :

Kamat, SS, Williams, HJ, Dangott, LJ, Chakrabarti, M, Raushel, F(2013) Thcatalytic mechanisfoaerobic formatioomethanby bacteria. Nature 497: 132-6

Ghodge, SV, Fedorov, AA, Fedorov, EV, Hillerich, B, Seidel, R, Almo, SC, Raushel, F(2013) StructuraanMechanistic Characterizatiool-HistidinoPhosphatPhosphatasfrothPolymerasanHistidinoPhosphatasFamily oProteins. Biochemistry 52: 1101-12

Fan, H, Hitchcock, DS, Seidel, R2nd, Hillerich, B, Lin, H, Almo, SC, Sali, A, Shoichet, BK, Raushel, F(2013) Assignment opterideaminasactivity taenzymounknowfunctioguideby homology modeling andocking. J. Am. Chem. Soc. 135: 795-803

Hobbs, ME, Vetting, M, Williams, HJ, Narindoshvili, T, Kebodeaux, DM, Hillerich, B, Seidel, RD, Almo, SC, Raushel, F(2013) Discovery oaL-fucono-1,5-lactonasfrocog3618 othamidohydrolassuperfamily. Biochemistry 52: 239-53

Ornelas, A, Korczynska, M, Ragumani, S, Kumaran, D, Narindoshvili, T, Shoichet, BK, Swaminathan, S, Raushel, F(2013) Functionaannotatioanthree-dimensionastructuroaincorrectly annotatedihydroorotasfrocog3964 ithamidohydrolassuperfamily. Biochemistry 52: 228-38

2012

TsaPC, FoN, Bigley AN, Harvey SP, BarondeaD& RausheF(2012) Enzymes fothHomelanDefense: Optimizing PhosphotriesterasfothHydrolysis oOrganophosphatNervAgents.Biochemistry 

FaF, Williams HJ, BoyeJG, GrahaTL, ZhaH, LehR, QH, Schwartz B, RausheF& Meek T(2012)Othcatalytic mechanisohumaATcitratlyase. Biochemistry 51: 5198-211

Bigley A& RausheF(2012) Catalytic mechanisms fophosphotriesterases. BiochiBiophys Acta 

Hobbs ME, Malashkevich V, Williams HJ, XC, SaudeJM, Burley SK, AlmSC & RausheF(2012)StructuranCatalytic MechanisoLigI: Insight intthAmidohydrolasEnzymes ocog3618 anLigniDegradation. Biochemistry 

Xiang DF, KolP, Fedorov AA, XC, Fedorov EV, NarindoshivilT, Williams HJ, Shoichet BK, AlmSC & RausheF(2012) Structure-basefunctiodiscovery oaenzymfothhydrolysis ophosphorylatesugalactones. Biochemistry 51: 1762-73

2011

Kamat SS, Williams HJ & RausheF(2011) Intermediates ithtransformatioophosphonates tphosphatby bacteria. Nature 480: 570-3

Gerlt JA, AlleKN, AlmSC, Armstrong RN, Babbitt PC, CronaJE, Dunaway-MarianD, ImkeHJ, JacobsoMP, MinoW, PoulteCD, RausheFM, SalA, Shoichet BK & SweedleJV (2011) ThEnzymFunctioInitiative. Biochemistry 50: 9950-62

Kamat SS, Holmes-HamptoGP, Bagaria A, KumaraD, Tichy SE, GheyT, Zheng X, BaiK, Groshong C, EmtagS, SaudeJM, Burley SK, SwaminathaS, LindahPA & RausheF(2011) Thcatalasactivity odiiroadenindeaminase. ProteiSci 20: 2080-94

GoblAM, FaH, SalA & RausheF(2011) Discovery oa cytokinideaminase. ACS CheBiol 6: 1036-40

GoblAM, Zhang Z, SaudeJM, Burley SK, SwaminathaS & RausheF(2011) Pa0148 froPseudomonas    aeruginosa catalyzes thdeaminatiooadenine. Biochemistry 50: 6589-97

Hitchcock DS, Fedorov AA, Fedorov EV, Dangott LJ, AlmSC & RausheF(2011) Rescuothorphaenzym                        isoguanindeaminase. Biochemistry 50: 5555-7

HalRS, Fedorov AA, XC, Fedorov EV, AlmSC & RausheF(2011) Three-dimensionastructurancatalytic                     mechanisoCytosindeaminase. Biochemistry 50: 5077-85

Kamat SS, FaH, SaudeJM, Burley SK, Shoichet BK, SalA & RausheF(2011) Enzymatic deaminatiooth                        epigenetic basN-6-methyladenine. J ACheSoc 133: 2080-3

RausheF(2011) Chemicabiology: Catalytic detoxification. Natur469: 310-1

Kamat SS, Bagaria A, KumaraD, Holmes-HamptoGP, FaH, SalA, SaudeJM, Burley SK, LindahPA, Swaminatha            S & RausheF(2011) Catalytic mechanisanthree-dimensionastructuroadenindeaminase. Biochemistry                 50: 1917-27

2010

M.E. Meyer, J.A. Gutierrez, F.M. Raushel, N.G. Richards, “A conserveglutamatcontrols thcommitment tacyl-adenylatformatioiasparaginsynthetase” Biochemistry 49, 9391-9401 (2010).

 

P.C. Tsai, A. Bigley, Y. Li, E. Ghanem, C.L. Cadieux, S.A. Kasten, T.E. Reeves, D.M. Cerasoli, F.M. Raushel, “Stereoselectivhydrolysis oorganophosphatnervagents by thbacteriaphosphotriesterase” Biochemistry 49, 7978-7987 (2010).

 

P.C. Tsai, Y. Fan, J. Kim, L. Yang, S.C. Almo, Y.Q. Gao, F.M. Raushel, “Structuradeterminants fothstereoselectivhydrolysis ochirasubstrates by phosphotriesterase” Biochemistry 49, 7988-7997 (2010).

 

D.F. Xiang, Y. Patskovsky, C. Xu, A.A. Fedorov, E.V. Fedorov, A.A. Sisco, S.K. Burley, S.C. Almo, F.M. Raushel, “Functionaidentificatioanstructurdeterminatiootwnoveprolidases frocog1228 ithamidohydrolassuperfamily” Biochemistry 49, 6791-6803 (2010).

 

R.S. Hall, R. Agarwal, D. Hitchcock, J.M. Sauder, S.K. Burley, S. Swaminathan, F.M. Raushel, “Discovery anstructurdeterminatioothorphaenzymisoxanthopterideaminase” Biochemistry 49, 4374-4382 (2010).

 

L. Lund, Y. Fan, Q. Shao, Y.Q. Gao, F.M. Raushel, “Carbamattransport icarbamoyphosphatsynthetase: a theoreticaanexperimentainvestigation” J ACheSoc 132, 3870-3878 (2010).

 

R.S. Hall, A.A. Fedorov, R. Marti-Arbona, E.V. Fedorov, P.Kolb, J.M. Sauder, S.K. Burley, B.K. Shoichet, S.C. Almo, F.M. Raushel, “Thhunt fo8-oxoguanindeaminase” J ACheSoc 132, 1762-1763 (2010).

 

J.A. Cummings, T.T. Nguyen, A.A. Fedorov, P. Kolb, C. Xu, E.V. Fedorov, B.K. Shoichet, D.Barondeau, S.C. Almo, F.M. Raushel, “Structure, mechanism, ansubstratprofilfoSco3058: thclosest bacteriahomologuthumarenadipeptidase” Biochemistry 49, 611-622 (2010).

2009

D.F. Xiang, P. Kolb, A.A. Fedorov, M.M. Meier, L.V. Fedorov, T.T. Nguyen, R. Sterner, S.C. Almo, B.K. Shoichet, F.M. Raushel, “Functionaannotatioanthree-dimensionastructuroDr0930 froDeinococcus radiodurans, a closrelativophosphotriesterasithamidohydrolassuperfamily” Biochemistry 10, 2237-2247 (2009).

 

U. Pieper, R. Chiang, J.J. Seffernick, S.D. Brown, M.E. Glasner, L. Kelly, N. Eswar, J.M. Sauder, J.B. Bonanno, S. Swaminathan, S.K. Burley, X. Zheng, M.R. Chance, S.C. Almo, J.A. Gerlt, F.M. Raushel, M.P. Jacobson, P.C. Babbitt, A. Sali, “Target selectioanannotatiofothstructuragenomics othamidohydrolasanenolassuperfamilies” J Struct Funct Genomics 10,  107-125 (2009).

 

D.F. Xiang, Y. Patskovsky, C. Xu, A.J. Meyer, J.M. Sauder, S.K. Burley, S.C. Almo, F.M. Raushel, “Functionaidentificatiooincorrectly annotateprolidases frothamidohydrolassuperfamily oenzymes” Biochemistry 48, 3730-3742 (2009).

 

D.F. Xiang, C. Xu, D. Kumaran, A.C. Brown, J.M. Sauder, S.K. Burley, S. Swaminathan, F.M. Raushel, “Functionaannotatiootwnew carboxypeptidases frothamidohydrolassuperfamily oenzymes” Biochemistry 48, 4567-4576 (2009).

 

J.A. Cummings, A.A. Fedorov, C. Xu, S. Brown, E. Fedorov, P.C. Babbitt, S.C. Almo, F.M. Raushel, “Annotating enzymes ouncertaifunction: thdeacylatiooD-aminacids by members othamidohydrolassuperfamily” Biochemistry 48, 6469-6481 (2009).

 

Y. Fan, L. Lund, Q. Shao, Y. Q. Gao, F.M. Raushel, “A combinetheoreticaanexperimentastudy othammonia tunneicarbamoyphosphatsynthetase” JACS 131, 10211-10219 (2009).

 

T.T. Nguyen, A.A. Fedorov, L. Williams, E.V. Fedorov, Y. Li, C. Xu, S.C. Almo, F.M. Raushel, “Thmechanisothreactiocatalyzeby uronatisomerasillustrates how aisomerasmay havevolvefroa hydrolaswithithamidohydrolassuperfamily” Biochemistry 48, 8879-8890 (2009).

 2008

J. Kim, P.C. Tsai, S.L. Chen, F. Himo, S.C. Almo, F.M. Raushel, “Structurodiethyphosphatbountthbinucleametacenteophosphotriesterase” Biochemistry 47, 9497-9504 (2008).

 

T. T. Nguyen, S. Brown, A. A. Fedorov, E. V. Fedorov, P. C. Babbitt, S. C. Almo, anF. M. Raushel, "At thPeriphery othAmidohydrolasSuperfamily: Bh0493 froBacillus halodurans Catalyzes thIsomerizatiooD-GalacturonattD-Tagaturonate" Biochemistry, 47, 1194-1206 (2008).

 

Y. Fan, L. Yang, L. Lund, F. M. Raushel, anY. Q. Gao, "ThMechanisfothTransport oAmmonia withiCarbamoyPhosphatSynthetasDetermineby MoleculaDynamics Simulations" Biochemistry 47, 2935-2944 (2008).

 

L. Williams, F. Fan, J. S. Blanchard, anF. M. Raushel, "PositionaIsotopExchangAnalysis othMycobacteriusmegmatis CysteinLigas(MshC)" Biochemistry 47, 4843-4850 (2008).

 

R. Sterner, R. Merkl, F. M. Raushel, "ComputationaDesigoEnzymes" Chemistry anBiology 15, 421-423 (2008).

 

R. Tyagi, S. Eswaramoorthy, S. K. Burley, F. M. Raushel, S. Swaminathan, "A CommoCatalytic MechanisfoProteins oHutFamily" Biochemistry 47, 5608-5615 (2008).

 

R. Z. Liao, J. G. Yu, F. M. Raushel, anF. Himo, "TheoreticaInvestigatioothReactioMechanisothDinucleaZinc EnzymDihydroorotase" Chemistry: A EuropeaJourna14, 4287-4292 (2008).

2007

 

Y. Li, F.M. Raushel, “Differentiatioochiraphosphorus enantiomers by anH NMspectroscopy using aminaciderivatives as chemicasolvating agents” TetrahedroAsymmetry 18, 1391-1397 (2007).

 

V. Fresquet, L. Williams, F.M. Raushel, “Partiarandomizatioothfousequentiaamidatioreactions catalyzeby cobyric acisynthetaswith a singlpoint mutation” Biochemistry 46, 13983-13993 (2007).

 

E. Ghanem, Y. Li, C. Xu, F.M. Raushel, “Characterizatiooa phosphodiesterascapablohydrolyzing EA 2192, thmost toxic degradatioproduct othnervagent VX” Biochemistry 46, 9032-40 (2007).

 

J.C. Hermann, R. Marti-Arbona, A.A. Fedorov, E. Fedorov, S.C. Almo, B.K. Shoichet, F.M. Raushel, “Structure-baseactivity predictiofoaenzymounknowfunction” Natur448, 775-778 (2007).

 

R.S. Hall, S. Brown, A.A. Fedorov, E. Fedorov, C. Xu, P.C. Babbitt, S.C. Almo, F.M. Raushel, “Structuradiversity withithmononucleaanbinucleaactivsites oN-acetyl-D-glucosamine-6-phosphatdeacetylase” Biochemistry 46, 7953-7962 (2007).

 

R.S. Hall, D.F. Xiang, C. Xu, F.M. Raushel, “N-Acetyl-D-glucosamine-6-phosphatdeacetylase: substratactivatiovia a singldivalent metaion” Biochemistry 46, 7942-7952 (2007).

 

C.R. Samples, F.M. Raushel, V.J. DeRose,  “Activatioothbinucleametacentethrough formatioophosphotriesterase-inhibitocomplexes” Biochemistry 46, 3435-3442 (2007).

 

L. Williams, V. Fresquet, P.J. Santander, F.M. Raushel, “Thmultiplamidatioreactions catalyzeby Cobyric acisynthetasfroSalmonella typhimuriuarsequentiaandissociative” JACS 129, 294-295 (2007).

 

G. Proteasa, Y.R. Tahboub, S. Galijasevic, F.M. Raushel, H.M. Abu-Soud, “Kinetic evidencsupports thexistencotwhalidbinding sites that hava distinct impact othhemiromicroenvironment imyeloperoxidase” Biochemistry 46, 398-405 (2007).

 

2006

R. Marti-Arbona, C. Xu, S. Steele, A. Weeks, G. F. Kuty, C. M. Seibert, anF. M. Raushel, “Annotating Enzymes oUnknowFunction: N-Formimino-L-GlutamatDeiminasis a MembeothAmidohydrolasSuperfamily” Biochemistry 45, 1997-2005 (2006).
 

Y. I. Korpan, F. M. Raushel, A. A. Nazarenko, A. P. Soldatkin, N. Jaffrezic-Renault, C. Martelet, “Sensitivity anSpecificity Improvement oISFET-baseBiosensofoPotatGlycolalkaloids Detection” JournaoAgriculturaanFooChemistry 54, 707-712 (2006).

 

C. Xu, R. Hall, J. Cummings, anF. M. Raushel, “Tight Binding Inhibitors oN-AcyAminSugaanAminAciDeacetylases” JournaothAmericaChemicaSociety 128, 4-4255 (2006).

 

Sakai, W. S. Yew, L. Song, D. F. Xiang, C. Xu, F. M. RausheanJ. A. Gerlt, “EvolutiooEnzymatic Activities ithEnolasSuperfamily:  N-SuccinylaminAciRacemasana New Pathway fothIrreversiblConversiooD-  tL-AminAcids” Biochemistry 45, 4455-4462 (2006).

 

L. Williams, T. Nguyen, Y. Li, T. N. Porter, anF. M. Raushel, “UronatIsomerase: A Nonhydrolytic MembeothAmidohydrolasSuperfamily with aAmbivalent Requirement foa Divalent MetaIon” Biochemistry 45, 7453-7462 (2006).

 

A. Weeks, L. Lund, anF. M. Raushel, “Tunneling oIntermediates iEnzyme-CatalyzeReactions” Current OpinioiChemicaBiology 10, 465-472 (2006).

 

R. Marti-Arbona anF. M. Raushel, “Mechanistic CharacterizatiooN-Formimino-L-GlutamatIminohydrolasfroPseudomonas aeruginosa” Biochemistry 45, 14256-14262 (2006).

 

J. C. Hermann, E. Ghanem, Y. Li, F. M. Raushel, J. J. Irwin, anB. K. Shoichet, “Predicting Substrates by Docking High-Energy Intermediates tEnzymStructures” JournaothAmericaChemicaSociety 128, 15882-15891 (2006).

 

A. Nowlan, Y. Li, T. Evans, J. Carpenter, E. Ghanem, J. C. Hermann, B. K. Shoichet, anF. M. Raushel, “ResolutiooChiraPhosphate, Phosphonate, anPhosphinatEsters by aEnantioselectivEnzymLibrary” JournaothAmericaChemicaSociety 128, 15892-15902, (2006).

 

R. Marti-Arbona, J.B. Thoden, H.M. Holden, F.M. Raushel, “FunctionasignificancoGlu-77 anTyr-137 withithactivsitoisoaspartydipeptidase” Bioorg Che33, 448-458 (2005).

 

2005

Y. Li, F.M. Raushel, “Inhibitors designefothactivsitodihydroorotase” Bioorg Che33, 470-483 (2005).

 

J.J. Irwin, F.M. Raushel, B.K. Shoichet, “Virtuascreening against metalloenzymes foinhibitors ansubstrates” Biochemistry 44, 12316-12328 (2005).

 

C.R. Samples, T. Howard, F.Raushel, V.J. DeRose, “Protonatioothbinucleametacentewithithactivsitophosphotriesterase” Biochemistry 44, 11005-11013 (2005).

 

E. Ghanem, F.M. Raushel, “Detoxificatiooorganophosphatnervagents by bacteriaphosphotriesterase” ToxicoAppPharmaco207, 459-470 (2005).

 

R. Marti-Arbona, V. Fresquet, J.B. Thoden, M.L.Davis, H.M. Holden, F.M. Raushel, “Mechanisothreactiocatalyzeby isoaspartydipeptidasfroEscherichia coli” Biochemistry 44, 7115-7124 (2005).

 

C.M. Seibert, F.M. Raushel,  “Structuraancatalytic diversity withithamidohydrolassuperfamily” Biochemistry 44, 6393-6391 (2005).

2004

 

V. Fresquet, J. B. Thoden, H. M. Holden, anF. M. Raushel, "Kinetic MechanisoAsparaginSynthetasfroVibrCholerae" Bioorganic Chemistry 32, 63-75 (2004).

 

J. Kim, anF. M. Raushel, "Access tthcarbamattunneocarbamoyphosphatsynthetase" Archives oBiochemistry anBiophysics 425, 33-41 (2004).

 

J. Kim, anF. M. Raushel, "PerforatioothTunneWaliCarbamoyPhosphatSynthetasDerails thPassagoAmmonia betweeSequentiaActivSites" Biochemistry 43, 5334-5340 (2004).

 

S. D. Aubert, Y. Li, anF. M. Raushel, "MechanisfothHydrolysis oOrganophosphates by thBacteriaPhosphotriesterase" Biochemistry 43, 5707-5715 (2004).

 

S. H. Hong anF. M. Raushel, "ControoStereoselectivity iPhosphotriesterase" Methods iEnzymology 388, 256-266 (2004).

 

Y. Li, S. D. Aubert, E. G. Maes, anF. M. Raushel, "Enzymatic ResolutiooChiraPhosphinatEsters" JournaothAmericaChemicaSociety 126, 29, 8888-8889 (2004).

 

M.-S. Park, C. M. Hill, Y. Li, R. K. Hardy, H. Khanna, Y. H. Khang, F. M. Raushel, "Catalytic properties othPepQ prolidasfroEscherichia coli" Archives oBiochemistry anBiophysics 429, 224-230 (2004).

 

V. Fresquet, L. Williams, anF. M. Raushel, "MechanisoCobyrinic Acia,c-DiamidSynthetasfroSalmonella typhimuriuLT2" Biochemistry, 43, 33, 10619-10627 (2004).

 

T. N. Porter, Y. Li, anF. M. Raushel, "MechanisoDihydroorotasReaction" Biochemistry 43, 51, 16285-16292 (2004).

 

J. B. Thoden, Z. Huang,  J. Kim, F. M. Raushel, anH. M. Holden, "Long RangAllosteric Transitions iCarbamoyPhosphatSynthetase" ProteiScienc13, 2398-2405 (2004).

 

H. M. Abu-Soud, F. M. Raushel, anS., "A NoveMultisteMechanisfoOxygeBinding tFerrous Hemoproteins:  RapiKinetic Analysis oFerrous-Dioxy Myeloperoxidas(CompounIII) Formation" Biochemistry 43, 11589-11595 (2004).

 

2003

C.M. Hill, W.S. Li, J.B. Thoden, H.M. Holden, F.M. Raushel, “Enhancedegradatioochemicawarfaragents through moleculaengineering othphosphotriesterasactivsite” JACS 125, 8990-8991 (2003).

 

J.B. Garrett, L.S. Mullins, F.M. Raushel, “Effect olinkesequencothstability ocircularly permutevariants oribonucleasT1” Bioorg Che31, 412-424 (2003).

 

K.T. Lum, H.J. Huebner, Y. Li, T.D. Phillips, F.M. Raushel, “Organophosphatnervagent toxicity iHydra attenuate” CheRes Toxico16, 953-957, (2003).

 

F.M. Raushel, J.B. Thoden, H.M. Holden, “Enzymes with moleculatunnels” Acc CheRes 36, 539-548 (2003).

 

Y. Li, S.D. Aubert, F.M. Raushel, “Operationacontroostereoselectivity during thenzymatic hydrolysis oracemic organophosphorus compounds” JACS 125, 7526-7527 (2003).

 

L. Williams, R. Zheng, J.S. Blanchard, F.M. Raushel, “Positionaisotopexchanganalysis othpantothenatsynthetasreaction” Biochemistry 42, 5108-5113 (2003).

 

J.B. Thoden, R. Marti-Arbona, F.M. Raushel, H.M. Holden, “High-resolutioX-ray structuroisoaspartydipeptidasfroEscherichia coli” Biochemistry 42, 4874-4882 (2003).

 

J.B. Thoden, J. Kim, F.M. Raushel, H.M. Holden,  “Thcatalytic mechanisogalactosmutarotase” ProteiScienc12, 1051-1059 (2003).

 

J.A. Gerlt, F.M. Raushel, “Evolutioofunctioi(beta/alpha)8-barreenzymes” Current Opinions iChemicaBiology 7, 252-264 (2003).

 

B. W. Miles, J. B. Thoden, H. M. Holden, anF. M. Raushel, "InactivatioothAmidotransferasActivity oCarbamoyPhosphatSynthetasby thAntibiotic Acivicin" JournaoBiologicaChemistry 277, 4368-4373 (2002).

 

2002

O. Pierrat anF. M. Raushel, "A FunctionaAnalysis othAllosteric NucleotidMonophosphatbinding SitoCarbamoyPhosphatSynthetase" Archives oBiochemistry & Biophysics 400, 34-42 (2002).

 

O. Pierrat, F. Javid-MajanF. M. Raushel, "DissectioothConduit foAllosteric ControoCarbamoyPhosphatSynthetasby Ornithine" Archives oBiochemistry & Biophysics 400, 26-33 (2002).

 

W. Li, Y. Li, C. M. Hill, K. T. Lum, anF. M. Raushel, "Enzymatic Synthesis oChiraOrganophosphothioates froProchiraPrecursors" JournaoAmericaChemicaSociety 124, 3498-3499 (2002).

 

F. M. Raushel, "BacteriaDetoxificatiooOrganophosphatNervAgents" Current OpinioiMicrobiology 5, 288-295 (2002).

 

J. Kim, S. Howell, X. Huang, anF. M. Raushel, "StructuraDefects withithCarbamatTunneoCarbamoyPhosphatSynthetase" Biochemistry 41, 12575-12581 (2002).

 

J. Thoden, X. Huang, F. M. Raushel, anH. M. Holden, "CarbamoyPhosphatSynthetase: CreatiooaEscapRoutfoAmmonia" JournaoBiologicaChemistry 277, 39722-39727 (2002).

 

 J. B. Thoden, J. Kim, F. M. Raushel, anH. M. Holden,  "StructuraanKinetic Studies oSugaBinding tGalactosMutarotasfroLactococcus lactis" JournaoBiologicaChemistry 277, 45458-45465 (2002).

 

2001

M.A. Anderson, H. Shim, F.M. Raushel, W.W.Cleland, “Hydrolysis ophosphotriesters: determinatiootransitiostates iparallereactions by heavy-atoisotopeffects” JACS 123, 9246-9253 (2001).

 

M.M. Benning, H. Shim, F.M.Raushel, H.Holden,  “High resolutioX-ray structures odifferent metal-substituteforms ophosphotriesterasfroPseudomonas diminuta” Biochemistry 40, 2712-2722 (2001).

 

M. Chen-Goodspeed, M.A. Sogorb, F. Wu, S.B. Hong, F.M. Raushel, “Structuradeterminants othsubstratanstereochemicaspecificity ophosphotriesterase” Biochemistry 40, 1325-1331 (2001).

 

M. Chen-Goodspeed, M.A. Sogorb, F. Wu, F.M. Raushel, “Enhancement, relaxation, anreversaothstereoselectivity fophosphotriesterasby rationaevolutiooactivsitresidues” Biochemistry 40, 1332-1339 (2001).

 

C.M. Hill, W.S. Li, T.C. Cheng, J.J. DeFrank, F.M. Raushel,  “Stereochemicaspecificity oorganophosphorus acianhydrolastowarp-nitrophenyanalogs osomaansarin” Bioorg Che29, 27-35 (2001).

 

X. Huang, H.Holden, F.M. Raushel, “Channeling osubstrates anintermediates ienzyme-catalyzereactions” AnnRev Bioche70, 149-180 (2001).

 

J. Kim, F.M. Raushel, “Allosteric controotholigomerizatioocarbamoyphosphatsynthetasfroEscherichia coli” Biochemistry 40, 11030-11036 (2001).

 

W.S. Li, K.T. Lum, M. Chen-Goodspeed, M.A. Sogorb, F.M. Raushel,  “Stereoselectivdetoxificatioochirasariansomaanalogues by phosphotriesterase” Bioorg MeChe9, 2083-2091 (2001).

 

J.B. Thoden, G.N. Phillips Jr., T.M. Neal, F.Raushel, H.M. Holden, “Moleculastructurodihydroorotase: a paradigfocatalysis through thusoa binucleametacenter” Biochemistry 40, 6989-6997 (2001).

 

F. Javid-Majd, L. S. Mullins, F. M. Raushel, anM. A. Stapleton, “ThDifferentially ConserveResidues oCarbamoyPhosphatSynthetase” JournaoBiologicaChemistry 275, 5073-5080 (2000).

 

2000 anBefore

X. Huang anF. M. Raushel, “AEngineereBlockagwithithAmmonia TunneiCarbamoyPhosphatSynthetasPrevents othUsoGlutaminas a Substratbut not Ammonia” Biochemistry 39, 3240-3247 (2000).

 

M. RausheanH. M. Holden, “Phosphotriesterase: AEnzymiSearch oIts NaturaSubstrate” Advances iEnzymology 74, 51-93 (2000).

 

B. W. Miles anF. M. Raushel, “SynchronizatioothThreReactioCenters withiCarbamoyPhosphatSynthetase” Biochemistry 39, 5051-5056 (2000).

 

H. ShianF. M. Raushel, “Self-Assembly othBinucleaMetaCenteoPhosphotriesterase” Biochemistry 39, 7357-7364 (2000).

 

C. Hill, F. Wu, T. Chen., J. DeFrank, anF. M. Raushel, “SubstratanStereochemicaSpecificity othOrganophosphorus AciAnhydrolasfroAlteromonas sp. JD6.5 Towarp-NitrophenyPhosphotriesters" Bioorganic anMedicinaChemistry Letters 10, 1285-1288. (2000).

 

V.L. Healy, L.S. Mullins, X. Li, S.E. Hall, F.M. Raushel, anC.T. Walsh, “D-Ala-D-Ligases: EvaluatiooD-AlanyPhosphatIntermediatby MIX, PIanRapiQuench Studies” Chemistry anBiology 7, 505-514 (2000).

 

X. Huang anF. M. Raushel, “RolothHingLooLinking thN- anC-TerminaDomains othAmidotransferasSubunit oCarbamoyPhosphatSynthetase” Archives oBiochemistry anBiophysics 380, 174-180 (2000).

 

X. Huang anF. M. Raushel, “RestrictePassagoReactioIntermediates Through thAmmonia TunneoCarbamoyPhosphatSynthetase” JournaoBiologicaChemistry 275, 26233-26240 (2000).

 

W. Zhu, F. Wu, F. M. Raushel, anG. Vigh, “Capillary Electrophoretic SeparatioothEnantiomers oOrganophosphates with a Phosphorus Stereogenic CenteUsing Octakis(2,3-diacetyl-6-sulfato)-g-cyclodextrias Resolving Agent” JournaoChromatography 895, 247-254 (2000).

 

W. Zhu, W.-S. Li, F. M. Raushel, anG. Vigh, “ExperimentaVerificatiooa Predicted, HithertUnseeSeparatioSelectivity PatterithCapillary Electrophoretic SeparatiooNonchareEnantiomers by Octakis(2,3-Diacetyl-6-Sulfato)--Cylclodextrin” Electrophoresis 21, 3249-3256 (2000).

 

M. M. Benning, S. B. Hong, F. M. RausheanH. M. Holden, “ThBinding oSubstratAnalogs tPhosphotriesterase” JournaoBiologicaChemistry 275, 30546-30550 (2000).

 

F. Wu, W.-S. Li, M. Chen-Goodspeed, M. Sogorb, anF. M. Raushel, “Rationally EngineereMutants oPhosphotriesterasfoPreparativScalIsolatiooChiraOrganophosphates” JournaoAmericaChemicaSociety 122, 10206-10207 (2000).

 

J. B. Thoden, F. M. Raushel, M. M. Benning, I. Rayment, anH. M. Holden, "ThStructuroCarbamoyPhosphatSynthetasDeterminet2.1 Å Resolution" Acta Crystallographic Part 55, 8-24 (1999).

 

S.-Hong anF. M. Raushel, "StereochemicaConstraints othSubstratSpecificity oPhosphotriesterase" Biochemistry 38, 1159-1165 (1999).

 

 B. L. Braxton, L. S. Mullins, F. M. RausheanG. D. Reinhart, "Allosteric DominanciCarbamoyPhosphatSynthetase" Biochemistry 38, 1394-1401 (1999).

 

M. Raushel, L. S. Mullins anG. Gibson, "DetectiooIntermediates ithCarbamoyPhosphatSynthetasReaction" iEnzymMechanisms (P. A. Frey anD. B. Northrop, eds.) IOS Press, Amsterdam, Netherlands pp. 61-71 (1999).

 

J. B. Thoden, G. Wesenberg, F. M. RausheanH. M. Holden, "CarbamoyPhosphatSynthetase: ClosurothB-domaias a Result oNucleotidBinding" Biochemistry 38, 2347-2357 (1999).

 

L. M. Mullins anF. M. Raushel, "Channeling oAmmonia Through thIntermoleculaTunneContainewithiCarbamoyPhosphatSynthetase" JournaoAmericaChemicaSociety 121, 3803-3804 (1999).

 

F.M. Raushel, J. B. ThodeanH. M. Holden, "ThAmidotransferasFamily oEnzymes: MoleculaMachines fothProductioanDelivery oAmmonia" Biochemistry 38, 7891-7899 (1999).

 

S. B. Hong anF. M. Raushel, "StereochemicaPreferences foChiraSubstrates by thBacteriaPhosphotriesterase" Chemico-BiologicaInteractions 119, 225-234 (1999).

 

T. O. Baldwin, M. M. ZeigleanF. M. Raushel, "Structure, Folding, anMechanisoBacteriaLuciferase, iBioluminescencanChemiluminescence: Perspectivfoth21^st Centrury. (Roda, K. A., Pazzagli, M., Kricka, L. J. anStanley, P. E., eds.) JohWiley & Sons, Englanpp. 376-379 (1999).

 

K. Tuovinen, E. Kaliste-Korhonen, F. M. RausheanO. Hanninen, "Success oPyridostigmine, Physostigmine, EptastigminanPhosphotriesterasTreatments iAcutSariIntoxication" Toxicology 134, 169-178 (1999).

 

J. Thoden, F. M. Raushel, G. Wesenburg anH. M. Holden, "ThBinding oInosinMonophosphattE. colCarbamoyPhosphatSynthetase" JournaoBiologicaChemistry 274, 22502-22507 (1999).

 

S.B. Hong anF. M. Raushel, "StereochemicaConstraints othCatalytic Hydrolysis oOrganosphosphatNervAgents by Phosphotriesterase" Phosphorus, Sulfur, anSilicoanthRelateElements 144, 521-524 (1999).

 

M. Chen-Goodspeed, J. Vanhooke, H. M. HoldeanF. M. Raushel, "Kinetic MechanisoKanamyciNucleotidyltransferasfroStapylococcus Aureus" Bioorganic Chemistry 27, 395-408 (1999).

 

 X. Huang anF. M. Raushel, "DeconstructioothCatalytic Array withithAmidotransferasSubunit oCarbamoyPhosphatSynthetase" Biochemistry 38, 15909-15914 (1999).

 

 J. B. Thoden, X. Huang, F. M. Raushel, anH. M. Holden, "CarbamoyPhosphatSynthetase: Snapshots Along thReactioPathway" Biochemistry 38, 16158-16166 (1999).

 

 H. M. Holden, F. M. Raushel, anJ. B. Thoden, "CarbamoyPhosphatSynthetase: AAmazing BiochemicaOdyssey froSubstrattProduct" CellulaanMoleculaLifSciences 56, 507-522 (1999).

 

W. A. Francisco, H. M. Abu-Soud, A. DeMonte, D. Singleton, T. O. BaldwianF. M. Raushel, "DeuteriuKinetic IsotopEffect anthMechanisothBacteriaLuciferasReaction" Biochemistry 37, 2596-2606 (1998).

 

J. B. Thoden, S. G. Miran, J. C. Phillips, A J. Howard, F. M. RausheanH. M. Holden, "CarbamoyPhosphatSynthetase: Caught ithAct oGlutaminHydrolysis" Biochemistry 37, 8825-8831 (1998).

 

 H. Shim, S. B. Hong anF. M. Raushel, "Hydrolysis oPhosphodiesters through TransformatioothBacteriaPhosphotriesterase" JournaoBiologicaChemistry 273, 17445-17450 (1998).

 

F.M. Raushel, L. S. Mullins anG. E. Gibson, "A Stringent Test fothNucleotidSwitch MechanisoCarbamoyPhosphatSynthetase" Biochemistry 37, 10272-10278 (1998).

 

F. M. Raushel, J. B. Thoden, G. D. Reinhart anH. M. Holden, "CarbamoyPhosphatSynthetase: A CrookePath froSubstrates tProducts" Current OpinioiChemicaBiology 2, 624-632 (1998).

 

 B. W. Miles, J. A. Banzon, anF. M. Raushel, "Regulatory ControothAmidotransferasDomaioCarbamoyPhosphatSynthetase" Biochemistry 37, 16773-16779 (1998).

 

 H. M. Holden, J. B. Thoden, anF. M. Raushel, "CarbamoyPhosphatSynthetase: A TunneRuns Through It" Current OpinioiStructuraBiology 8, 679-685 (1998).

 

G. W. Gibson, L. S. Mullins, anF. M. Raushel, "CarbamoyPhosphatSynthetasfroEscherichia coldoes not CatalyzthDehydratiooBicarbonattCarboDioxide" Bioorganic Chemistry 26, 255-268 (1998).

 

J. M. Kuo, M. Y. ChaanF. M. Raushel, "Perturbations tthActivSitoPhosphotriesterase" Biochemistry 36, 1982-1988 (1997).

 

 J. B. Thoden, H. M. Holden, G. Wesenberg, F. M. RausheanI. Rayment, "ThStructuroCarbamoyPhosphatSynthetase: A Journey o96: froSubstrattProduct" Biochemistry 36, 6305-6316 (1997).

 

S. B. Hong, L. S. Mullins, H. Shim, anF. M. Raushel, "Mechanism-BaseInhibitors fothInactivatioothBacteriaPhosphotriesterase" Biochemistry 36, 9022-9028 (1997).

 

L. S. Mullins, S. B. Hong, G. E. Gibson, H. Walker, T. C. StadtmaanF. M. Raushel, "Identificatiooa PhosphorylateEnzymIntermediatithCatalytic MechanisfoSelenophosphatSynthetase" JournaoAmericaChemicaSociety 119, 6684-6685 (1997).

 

 H. M. Abu-Soud, R. Batchui, F. M. RausheanD. J. Stuehr, "ThFerrous-dioxy CompleoNeuronaNitric-oxidSynthase" JournaoBiologicaChemistry 272, 17349-17353 (1997).

 

 L. S. Mullins, C. N. PacanF. M. Raushel, "ConformationaStability oRibonucleasT1 Determineby Hydrogen-DeuteriuExchange" ProteiScienc6, 1387-1395 (1997).

 

S. B. Hong anF. M. Raushel, "Inhibitors DirecteTowards thBinucleaMetaCenteoPhosphotriesterase" JournaoEnzymInhibitio12, 191-203 (1997).

 

L. M. Watkins, H. J. Mahoney, J. K. McCulloch anF. M. Raushel, "AugmenteHydrolysis oDFiEngineereMutants oPhosphotriesterase" JournaoBiologicaChemistry 272, 25596-25627 (1997).

 

T. O. Baldwin, M. M. Ziegler, A. C. Clark, J. F. Sinclair, F. M. Raushel, I. Rayment, H. M. Holden, A. J. Fisher, T. B. Thompson, anJ. B. Thoden, "StructuranFolding oBacteriaLuciferase" iFlavins anFlavoproteins (1996).

 

K. J. Stevenson, V. Massey anC. H. Williams, eds) University oCalgary Press, pp. 347-356 (1997).

 

 L. M. Watkins, J. M. Kuo, M. Chen-GoodspeeanF. M. Raushel, "A CombinatoriaLibrary fothBinucleaMetaCenteoBacteriaPhosphotriesterase" PROTEINS: Structure, FunctioanGenetics 29, 553-561 (1997).

 

W. A. Francisco, H. M. Abu-Soud, R. Topgi, T. O. BaldwianF. M. Raushel, "InteractiooBacteriaLuciferaswith 8-SubstituteFlaviMononucleotidDerivatives" JournaoBiologicaChemistry 271, 104-110 (1996).

 

 J. B. Garrett, L. S. Mullins anF. M. Raushel, "ArTurns RequirefothFolding oRibonucleasT1" ProteiScienc5, 204-211 (1996).

 

 J. L. Vanhooke, M. M. Benning, F. M. Raushel, anH. M. Holden, "Three-DimensionaStructurothZinc-Containing Phosphotriesteraswith thBounSubstratAnalog Diethy4-Methylbenzylphosphonate" Biochemistry 35, 6020-6025 (1996).

 

K. Tuovinen, E. Kaliste-Korhonen, F. Raushel, anO. Hanninen, "ProtectiooOrganophosphate-InactivateEsterases with Phosphotriesterase" Fundamenta& AppliePharmacology 31, 210-217 (1996).

 

 J. L. JohnsoanF. M. Raushel, "ThInfluencoPrimary SequencTranspositions othFolding Pathways oRibonucleasT1" Biochemistry 35, 10223-10233 (1996).

 

S.-B. Hong anF. M. Raushel, "Metal-SubstratInteractions FacilitatthCatalytic Activity othBacteriaPhosphotriesterase" Biochemistry 35, 10904-10912 (1996).

 

B. L. Braxton, L. S. Mullins, F. M. RausheanG. D. Reinhart, "ThAllosteric Effects oCarbamoyPhosphatSynthetasfroE. colarEntropy-Driven" Biochemistry 35, 11918-11924 (1996).

 

L. C. Lo, C. H. Lo, K. D. Janda, D. B. KasseanF. M. Raushel, "A VersatilMechanisBaseReactioProbfothDirect SelectiooBiocatalysts" Bioorganic & MedicinaChemistry Letters 6, 2117-2120 (1996).

 

 M. A. Stapleton, F. Javid-Majd, M. F. Harmon, B. A. Hanks, J. L. Grahmann, L. S. Mullins anF. M. Raushel, "RoloConserveResidues WithithCarboxy PhosphatDomaioCarbamoyPhosphatSynthetase" Biochemistry 35, 14352-14361 (1996).

 

 F. Javid-Majd, M. A. Stapleton, M. F. Harmon, B. A. Hanks, L. S. Mullins anF. M. Raushel, "ComparisoothFunctionaDifferences fothHomologous Residues WithithCarboxy PhosphatanCarbamatDomains oCarbamoyPhosphatSynthetase" Biochemistry 35, 14362-14369 (1996).

 

K. Tuovinen, E. Kaliste-Korhonen, F. M. RausheanO. Hanninen, "Eptastigmine-PhosphotriesterasCombinatioiDFIntoxication" Toxicology anAppliePharmacology 140, 364-369 (1996).

 

K. Tuovinen, E. Kaliste-Korhonen, F. M. RausheanO. Hanninen, "Phosphotriesterase, Pralidoxime-2-Chlorid(2-PAM) anEptastigminTreatments anTheiCombinations iDFIntoxication" Toxicology & AppliePharmacology 141, 555-560 (1996).

 

L. S. Mullins anF. M. Raushel, "PositionaIsotopExchangas a ProboEnzymAction" iEnzymKinetics anMechanism, Part (Ed. D. L. Purich) Academic Press 249, 398-425 Methods iEnzymology (1995).

 

J. Thoden, F. M. Raushel, S. Mareya, D. R. Tomchick anI. Rayment, "CrystallizatioanPreliminary X-ray Crystallographic Analysis oCarbamoyPhosphatSynthetasfroEscherichia coli" Acta Crystallographica, Part 51, 827-829. (1995).

 

M. Y. Chae, G. A. Omburo, P. A. Lindahl, anF. M. Raushel, "UtilizatiooCoppeas a Paramagnetic ProbfothBinucleaMetaCenteoPhosphotriesterase" Archives oBiochemistry & Biophysics 316, 765-772 (1995).

 

J. A. Banzon, J. M. Kuo, B. W. Miles, D. R. Fischer, P. J. Stang anF. M. Raushel, "Mechanism-BaseInactivatiooPhosphotriesterasby Reactiooa CriticaHistidinwith a KetenIntermediate" Biochemistry 34, 743-749 (1995).

 

 J. A. Banzon, J. M. Kuo, D. R. Fischer, P. J. Stang anF. M. Raushel, "Histidine-254 oPhosphotriesterasis EssentiafoInactivatiowith thAlkynyPhosphatEsters anDiethyPyrocarbonate" Biochemistry 34, 750-754 (1995).

 

J. M. Kuo, L. S. Mullins, J. B. Garrett anF. M. Raushel, "CirculaPermutatiooRNasT1 Through PCBaseSite-DirecteMutagenesis" Techniques iProteiChemistry V(J. W. Crabb, ed) Academic Press pp. 333-340 (1995).

 

 S. M. Mareya anF. M. Raushel, "Mapping thFunctionaDomains oE. colCarbamoyPhosphatSynthetasUsing LimiteProteolysis" Bioorganic & MedicinaChemistry 3, 525-532 (1995).

 

Frank M. Raushel, "StructuraanMechanistic Investigations oCarbamoyPhosphatSynthetasfroE. coli" Pathways tPyrimidines: AInternationaNewslette3, 1-8 (1995).

 

A. J. Fisher, F. M. Raushel, T. O. BaldwianI. Rayment, "ThThree-dimensionaStructuroBacteriaLuciferasfroVibriharveyat 2.4 A Resolution" Biochemistry 34, 6581-6586 (1995).

 

M. M. Benning, J. M. Kuo, F. M. RausheanH. M. Holden, "Three-DimensionaStructurothBinucleaMetaCenteoPhosphotriesterase" Biochemistry 34, 7973-7978 (1995).

 

S.-B. Hong, J. M. Kuo, L. S. Mullins anF. M. Raushel, "CO₂ is RequirefothAssembly othBinucleaMetaCenteoPhosphotriesterase" JournaoAmericaChemicaSociety 117, 7581-7582 (1995).

 

R. M. Czerwinski, S. M. Mareya anF. M. Raushel, "Regulatory Changes ithControoCarbamoyPhosphatSynthetasInduceby TruncatioanMutagenesis othAllosteric Binding Domain" Biochemistry 34, 13920-13927 (1995).

 

L. S. Mullins, M. Y. ChaanF. M. Raushel, "Phosphorus-31 NMRelaxatioStudies oDiethyp-MethoxyphenyPhosphatBountPhosphotriesterase" Bioorganic anMedicinaChemistry Letters 5, 3067-3072 (1995).

 

 T. O. Baldwin, J. A. Christopher, F. M. Raushel, J. F. Sinclair, M. M. Zeigler, A. J. FisheanI. Rayment, "StructuroBacteriaLuciferase" Current OpinioiStructuraBiology 5, 798-809 (1995).

 

K. Tuovinen, E. Kaliste-Korhonen, F. M. RausheanO. Hanninen, "Phosphotriesteras- A Promising CandidatfousiDetoxificatiooOrganophosphates" Fundamenta&. ApplieToxicology 23, 578-584 (1994).

 

W. A. Francisco, H. M. Abu-Soud, A. C. Clark, F. M. RausheanT. O. Baldwin, "Kinetic MechanisothBacteriaLuciferasReaction" iFlavins anFlavoproteins, 1993 (K. Yagi, ed) WalteGruyte& Co. Berli(1994).

 

 S. M. Mareya anF. M. Raushel, "A MoleculaWedgfoTriggering thAmidotransferasActivity oCarbamoyPhosphatSynthetase" Biochemistry 33, 2945-2950 (1994).

 

 J. M. KuanF. M. Raushel, "IdentificatioothHistidinLigands tthBinucleaMetaCenteoPhosphotriesterasby Site-DirecteMutagenesis" Biochemistry 33, 4265-4272 (1994).

 

L. S. Mullins, K. Wesseling, J. M. Kuo, J. B. Garrett, anF. M. Raushel, "TranspositiooProteiSequences: CirculaPermutatiooRibonucleasT1" JournaoAmericaChemicaSociety 116, 5529-5233 (1994).

 

L. Pei, G. Omburo, W. D. McGuinn, I. Perikovics, K. Dave, F. M. Raushel, J. R. Wild, J. R. DeLoach anJ. L. Way, "EncapsulatiooPhosphotriesterasWithiMurinErythrocytes" Toxicology & AppliePharmacology 124, 296-301 (1994).

 

M. Y. Chae, J. F. Postula, anF. M. Raushel, "Stereospecific Enzymatic Hydrolysis oPhosphorus-SulfuBonds iChiraOrganophosphatTriesters" Bioorganic & MedicinaChemistry Letters 4, 1473-1478 (1994).

 

W. A. Francisco, H. M. Abu-Soud, F. M. RausheanT. O. Baldwin, "Studies othKinetic MechanisothBacteriaLuciferase-CatalyzeReaction" iBioluminescencanChemiluminescenc(A. A. Szalay, L. J. Kricka, anP. Stanley, eds) pp. 113-117 (1994).

 

 M. A. Benning, J. M. Kuo, F. M. RausheanH. M. Holden, "ThThree-DimensionaStructuroPhosphotriesterase: AEnzymCapabloDetoxifying Organophosphorus NervAgents" Biochemistry 33, 15001-15007 (1994).

 

Suk-bong Hong anFrank M. Raushel, "Synthesis anEnzymatic Hydrolysis oa Light-Emitting SubstratfoPhosphotriesterase" Bioorganic & MedicinaChemistry Letters 4, 2705-2708 (1994).

 

B. W. Miles, S. M. Mareya, L. E. Post, D. J. Post, S. H. Chang anF. M. Raushel, "DifferentiaRoles foThreConserveHistidinResidues WithithLargSubunit oCarbamoyPhosphatSynthetase" Biochemistry 32, 232-240 (1993).

 

E. Kaliste-Korhonen, P. Ylitalo, O. HannineanF. M. Raushe"PhosphotriesterasDecreases ParaoxoToxicity iMice" Toxicology & AppliePharmacology 121, 275 (1993).

 

H. M. Abu-Soud, A. C. Clark, W. A. Francisco, T. O. BaldwianF. M. Raushel, "Kinetic DestabilizatioothHydroperoxy FlaviIntermediatby Site-DirecteModificatioothReactivThioiBacteriaLuciferase" JournaoBiologicaChemistry 268, 7699-7706 (1993).

 

E. J. Rodriguez, C. Debouck, I. Deckman, H. Abu-Soud, F. M. RausheanT. D. Meek, "InhibitoBinding tthPhe53TrMutant oHIV-1 ProteasPromotes ConformationaChanges Detectablby Spectrofluorimetry" Biochemistry 32, 3557-3563 (1993).

 

R. Rajapaksa, H. Abu-Soud, F. M. Raushel, B. G. Harris anP. F. Cook, "Pre-steady StatKinetics Reveaa Slow IsomerizatioothEnzyme-NACompleithNAD-Malic EnzymReaction" Biochemistry 32, 1928-1934 (1993).

 

L. S. Mullins, C. N. PacanF. M. Raushel, "InvestigatiooRibonucleasT1 Folding by HydrogeDeuteriuAmidExchange-2NMSpectroscopy" Biochemistry 32, 6152-6156 (1993).

 

G. M. Omburo, L. S. Mullins anF. M. Raushel, "StructuraCharacterizatioothDivalent CatioSites oBacteriaPhosphotriesterasby ¹¹³CNMSpectroscopy" Biochemistry 32, 9148-9155 (1993).

 

W. A. Francisco, H. Abu-Soud, T. O. BaldwianF. M. Raushel, "InteractiooAldehydSubstrates anInhibitors tBacteriaLuciferase" JournaoBiologicaChemistry 268, 24734-24741 (1993).

 

 M. Y. Chae, G. E. Omburo, P. A. LindahanF. M. Raushel, "Antiferromagnetic Coupling ithBinucleaMetaCenteoMn-SubstitutePhosphotriesterase" JournaoAmericaChemicaSociety 115, 12173-12174 (1993).

 

H. M. Abu-Soud, L. S. Mullins, T. O. BaldwianF. M. Raushel, "A Stopped-Flow Kinetic Analysis othBacteriaLuciferasReaction" Biochemistry 31, 3807-3813 (1992).

 

 B. L. Braxton, L. S. Mullins, F. M. RausheanG. D. Reinhart, "Quantifying thAllosteric Properties oE. colCarbamyPhosphatSynthetase" Biochemistry 31, 2309-2316 (1992).

 

G. A. Omburo, J. M. Kuo, L. S. Mullins anF. M. Raushel, "CharacterizatioothZinc Binding SitoBacteriaPhosphotriesterase" JournaoBiologicaChemistry 267, 13278-13283 (1992).

 

F. M. Raushel, B. W. Miles, L. E. Post anD. J. Post, "MutationaAnalysis oTwPutativDomains WithithLargSubunit oCarbamoyPhosphatSynthetasfroE. coli" Bioorganic & MedicinaChemistry Letters 2, 319-322 (1992).

 

S. R. CaldwelanF. M. Raushel, "DetoxificatiooOrganophosphatPesticides Using aImmobilizePhosphotriesterasfroPseudomonas diminuta" Biotechnology anBioengineering 37, 103-109 (1991).

 

L. S. Mullins, C. J. Lusty anF. M. Raushel, "Alterations ithEnergetics oCarbamoyPhosphatSynthetasReactioby Site-DirecteModificatioothEssentiaSulfhydryGroup" JournaoBiologicaChemistry 266, 8236 (1991).

 

S. R. CaldwelanF. M. Raushel, "MechanisoEnzymatic PhosphotriesteHydrolysis", iChemicaAspects oEnzymBiotechnology: Fundamentals (T. O. Baldwin, F. M. Raushel, anA. I. Scott eds.) PlenuPress 41-52 (1991).

 

F. M. Raushel, H. M. Abu-Soud, L. S. Hester, W. FranciscanT. O. Baldwin, "Kinetic MechanisoBacteriaLuciferase" iFlavins anFlavoproteins 1990 (Curti, Ronchi, anZanetti, Eds.) WalteDGrute& Co. 273-276 (1991).

A.                   

L. J. Chlumsky, L. H. Chen, C. Clark, H. Abu-Soud, M. M. Zeigler, F. M. RausheanT. O. Baldwin, "RandoanSitDirecteMutagenesis oBacteriaLuciferase" iFlavins anFlavoproteins 1990 (Curti, Ronchi, anZanetti, Eds.) WalteDGrute& Co. 261-264 (1991).

 

S. R. Caldwell, F. M. Raushel, P. M. Weiss anW. W. Cleland, "Primary anSecondary Oxygen-18 IsotopEffects ithChemicaanEnzymatic Hydrolysis oPhosphotriesters" JournaoAmericaChemicaSociety 113, 730-732 (1991).

 

S. R. Caldwell, J. R. Newcomb, K. A. Schlecht anF. M. Raushel, "Limits oDiffusioithHydrolysis oSubstrates by thPhosphotriesterasfroPseudomonas diminuta" Biochemistry 30, 7438-7444 (1991).

 

S. R. Caldwell, F. M. Raushel, P. M. Weiss anW. W. Cleland, "TransitioStatStructures fothEnzymatic anChemicaHydrolysis oPhosphotriesters" Biochemistry 30, 7444-7450 (1991).

 

S. R. CaldwelanF. M. Raushe"DetoxificatiooOrganophosphatPesticides Using a NyloBaseImmobilizePhosphotriesterasfroPseudomonas Diminuta" ApplieBiochemistry & Biotechnology 31, 59-73 (1991).

 

 S. G. Miran, S. H. Chang anF. M. Raushel, "ThRolothFouConserveHistidinResidues ithAmidotransferasDomaioCarbamoyPhosphatSynthetase" Biochemistry 30, 7901-7907 (1991).

 

J. N. Blankenship, H. M. Abu-Soud, W. A. Francisco, F. M. Raushel, D. R. FischeanP. J. Stang, "Mechanism-BaseInactivatiooa BacteriaPhosphotriesterasby aAlkynyPhosphatEster" JournaoAmericaChemicaSociety 113, 8560-8561 (1991).

 

L. S. Mullins, L. E. Zawadzke, C. T. Walsh anF. M. Raushel, "Kinetic EvidencfothFormatiooAlanyl-phosphatithD-alanyl-alaninSynthetasReaction" JournaoBiologicaChemistry 265, 8993-8998 (1990).

 

 L. E. Post, D. J. Post anF. M. Raushel, "DissectioothFunctionaDomains oE. colCarbamoyPhosphatSynthetasby Site-DirecteMutagenesis" JournaoBiologicaChemistry 265, 7742-7747 (1990).

 

 D. P. Dumas anF. M. Raushel, "Kinetic anChemicaEvidencfoaEssentiaHistidinResiduithPhosphotriesterasoPseudomonas diminuta" JournaoBiologicaChemistry 265, 21498-21503 (1990).

 

D. P. Dumas, J. R. WilanF. M. Raushel, "Expressiooa BacteriaPhosphotriesterasithFalArmy WorConfers ResistanctOrganophosphatInsecticides" Experientia 46, 729-731 (1990).

 

M. McNutt, L. S. Mullins, F. M. RausheanC. N. Pac"ContributiooHistidinResidues tthConformationaStability oRibonucleasT1 anMutant Glu-58 tAla" Biochemistry 29, 7572-7576 (1990).

 

D. P. Dumas, J. R. WilanF. M. Raushel, "DiisopropylfluorophosphatHydrolysis by aOrganophosphatAnhydrasfroPseudomonas diminuta" Biotechnology anApplieBiochemistry 11, 235-243 (1989).

 

W. J. Donarski, D. P. Dumas, D. P. Heitmeyer, V. E. Lewis anF. M. Raushel, "Structure-Activity Relationships ithHydrolysis oSubstrates by thPhosphotriesterasfroPseudomonas diminuta" Biochemistry 28, 4650-4655 (1989).

 

D. P. Dumas, S. R. Caldwell, J. R. WilanF. M. Raushel, "PurificatioanProperties othPhosphotriesterasfroPseudomonas diminuta" JournaoBiologicaChemistry 264, 19659-19665 (1989).

 

D. P. Dumas, H. D. Durst, W. G. Landis, F. M. RausheanJ. R. Wild, "InactivatiooOrganophosphorus NervAgents by thPhosphotriesterasfroPseudomonas diminuta" Archives oBiochemistry & Biophysics 277, 155-159 (1989).

 

F. M. RausheanT. O. Baldwin, "ProposeMechanisfothBacteriaLuciferasReactioInvolving a DioxiranIntermediate" Biochemica& BiophysicaResearch Communications 164, 1137-1142 (1989).

 

V. E. Lewis, W. J. Donarski, J. R. WilanF. M. Raushel, "ThMechanisanStereochemicaCoursat Phosphorus othReactioCatalyzeby a BacteriaPhosphotriesterase" Biochemistry 27, 1591-1597 (1988).

 

S. C. KianF. M. Raushel, "ThInteractiooMonofluorofumaratWith AdenylosuccinatLyase" JournaoEnzymInhibitio2, 153-161 (1988).

 

A. N. Singh, J. S. NewboranF. M. Raushel, "Enzymatic Synthesis oUridine-5'-O-(2-thiodiphosphoglucose) anRelateSugaPhosphorothioates" Bioorganic Chemistry 16, 206-214 (1988).

 

S. C. Kim, A. N. Singh anF. M. Raushel, "ThMechanisoGlycogeSynthetasas Determineby DeuteriuIsotopEffects anPositionaIsotopExchangExperiments" JournaoBiologicaChemistry 263, 10151-10154 (1988).

 

F. M. RausheanJ. J. Villafranca, "PositionaIsotopExchange" CriticaReviews iBiochemistry 23, 1-26 (1988).

 

S. C. Kim, A. N. Singh anF. M. Raushel, "Analysis othGalactosyTransferasReactioby PositionaIsotopExchanganSecondary DeuteriuIsotopEffects" Archives oBiochemistry & Biophysics 267, 54-59 (1988).

 

J. D. Scholton, J. L. Hogg anF. M. Raushel, "MethyChymotrypsiCatalyzeHydrolyses oSpecific SubstratEsters IndicatMultiplProtoCatalysis is Possiblwith a ModifieChargRelay Triad" JournaoAmericaChemicaSociety 110, 8246-8247 (1988).

 

S. C. KianF. M. Raushel, "Mechanism-BaseInactivatiooRabbit MusclPhosphoglucomutasby Nojirimycin-6-Phosphate" Biochemistry 27, 7328-7332 (1988).

 

L.S.Hester, F.M. Raushel, “Determinatioothenergetics othUDP-glucospyrophosphorylasreactioby positionaisotopexchanginhibition” Biochemistry 26, 6465-6571 (1987).

 

L.S.Hester, F.M.Raushel, “Analysis oping-pong reactiomechanisms by positionaisotopexchange. Applicatiotgalactose-1-phosphaturidyltransferase” J BioChe262, 12092-12095 (1987).

 

L.M.Mallis, F.M. Raushel, D.H. Russell, “Differentiatiooisotopically labelenucleotides using fast atobombardment tandemass spectrometry” AnaChe59, 980-984 (1987).

 

A.N. Singh, L.S. Hester, F.M. Raushel, “Examinatioothmechanisosucrossynthetasby positionaisotopexchange” J BioChe262, 2554-2557 (1987).

J.R. Matos, F.M. Raushel, C.H. Wong, “S-adenosylmethionine: studies ochemicaanenzymatic synthesis” BiotechnoAppBioche9, 39-52 (1987).

 

S. C. KianF. M. Raushel, "ThDeterminatiooEnzyme-SubstratDissociatioRates by Dynamic IsotopExchangEnhancement Experiments" JournaoBiologicaChemistry 261, 8163-8166 (1986).

 

 T. L. Chapman, T. B. ShulanF. M. Raushel, "StereochemicaProbes othArgininosuccinatSynthetasReaction" Biochemistry 25, 4739-4744 (1986).

 

S. C. KianF. M. Raushel, "Isotopic Probes othArgininosuccinatLyasReaction" Biochemistry 25, 4744-4749 (1986).

 

L. J. Garrard, Q. T. N. Bui, R. NygaaranF. M. Raushel, "Acid-BasCatalysis ithArgininosuccinatLyasReaction" JournaoBiologicaChemistry. 260, 5548-5553 (1985).

 

L. W. Hilscher, C. Hanson, D. H. RusselanF. M. Raushel, "Measurement oPositionaIsotopExchangRates iEnzymes CatalyzeReactions by Fast AtoBombardment Mass Spectrometry: ApplicatiotArgininosuccinatSynthetase" Biochemistry 24, 5888-5893 (1985).

 

 C. GhosanF. M. Raushel, "DeterminatioothMechanisothArgininosuccinatSynthetasReactioby Static anDynamic Quench Experiments" Biochemistry 24, 5894-5898 (1985).

 

F. M. RausheanL. J. Garrard, "A PositionaIsotopExchangStudy othArgininosuccinatLyasReaction" Biochemistry 23, 1791-1795 (1984).

 

F. M. Raushel, "NitrAnalogs oSubstrates foArgininosuccinatSynthetasanArgininosuccinatLyase" Archives oBiochemistry & Biophysics 232, 520-525 (1984).

 

F. M. RausheanR. Nygaard, "Kinetic MechanisoBovinLiveArgininosuccinatLyase" Archives oBiochemistry & Biophysics 221, 143-147 (1983).

 

F. M. Raushel, P. M. AndersoanJ. J. Villafranca, "ANMStudy othTopography oBinding Sites oE. colCarbamoyPhosphatSynthetase" Biochemistry 22, 1872-1876 (1983).

 

L. J. Garrard, J. M. Mathis anF. M. Raushel, "Substrate-InduceInactivatiooArgininosuccinatLyasby MonofluorofumaratanDifluorofumarate" Biochemistry 22, 3729-3735 (1983).

 

F. M. RausheanJ. L. Seigle, "Kinetic MechanisoArginosuccinatSynthetase" Archives oBiochemistry & Biophysics 225, 979-985 (1983).

 

R. E. Viola, F. M. Raushel, A. R. Rendina anW. W. Cleland, "SubstratSynergisanthKinetic MechanisoYeast Hexokinase" Biochemistry 21, 1295-1302 (1982).

 

J. J. Villafranca anF. M. Raushel, "NManEPInvestigations oBi-MetallEnzymes" Advances iInorganic Biochemistry 4, 289-319 (1982).

 

J. J. Villafranca anF. M. Raushel, "ThMonovalent CatioSitoPyruvatKinasanOtheEnzymes: NMInvestigations" FederatioProceedings 41, 2961-2965 (1982).

 

B. A. Cunningham, F. M. Raushel, J. J. Villafranca anS. J. Benkovic, "Distances BetweeStructuraMetaIon, Substrates anthAllosteric ModifieoFructosBisphosphatase" Biochemistry 20, 359-362 (1981).

 

J. J. Villafranca, F. M. Raushel, R. P. Pillai, M. S. Balakrishnan, C. DeBrossanT. D. Meek, "³¹NMStudies oPhosphoryTransfeEnzymes" ACS SymposiuSeries, Phosphorus Chemistry 171, 131-134 (1981).

 

R. P. Pillai, F. M. RausheanJ. J. Villafranca, "Stereochemistry oBinding oThiophosphatAnalogs oATanADtCarbamatKinase, GlutaminSynthetase, anCarbamyl-PhosphatSynthetase" Archives oBiochemistry & Biophysics 199, 7-15 (1980).

 

J. J. Villafranca anF. M. Raushel, "BiophysicaApplicatiooNMtPhosphoryTransfeEnzymes anMetaNucleoMetalloproteins" AnnuaReview oBiophysics & Bioengineering 9, 363-392 (1980).

 

F. M. RausheanJ. J. Villafranca, "³¹NMApplicatiotthPositionaIsotopExchangReactions Catalyzeby E. colCarbamoyPhosphatSynthetase: Analysis othForwaranReversEnzymReactions" Biochemistry 19, 3170-3174 (1980).

 

 F. M. RausheanJ. J. Villafranca, "A Direct NMMethofothDeterminatiooCorrelatioTimes iEnzymComplexes Involving Monovalent Cations anParamagnetic Centers" JournaoAmericaChemicaSociety 102, 6618-1689 (1980).

 

F. M. RausheanJ. J. Villafranca "A MultinucleaNMStudy othMonovalent-Divalent CatioSites oPyruvatKinase" Biochemistry 19, 5481-5485 (1980).

 

F. M. RausheanJ. J. Villafranca, "DeterminatioothRate-Limiting Steps oEscherichia colCarbamoyPhosphatSynthetase: RapiQuench anIsotopPartitioning Experiments" Biochemistry 18, 3424-3429 (1979).

 

 F. M. Raushel, C. J. Rawding, P. M. AndersoanJ. J. Villafranca, "Paramagnetic Probes foCarbamoyPhosphatSynthetase: MetaIoBinding Studies anPreparatiooNitroxidSpiLabeleDerivatives" Biochemistry 18, 5562-5566 (1979).

 

J. J. Villafranca anF. M. Raushel, "MetalloenzymCatalysis" Advances iCatalysis 28, 324-369 (1979).

 

F. M. Raushel, P. M. AndersoanJ. J. Villafranca, "CarbamoyPhosphatSynthetasoEscherichia colUses thSamDiastereomeoAdenosine-5'-2-thiotriphosphatat Both ATSites"  JournaoBiologicaChemistry 253, 6627-6629 (1978).

 

 F. M. Raushel, P. M. AndersoanJ. J. Villafranca, "Kinetic MechanisoEscherichia colCarbamoyPhosphatSynthetase" Biochemistry 17, 5587-5591 (1978).

 

 F. M. RausheanW. W. Cleland, "BovinLiveFructokinase: PurificatioanKinetic Properties" Biochemistry 16, 2169-2175 (1977).

 

F. M. RausheanW. W. Cleland, "DeterminatioothRate-Limiting Steps anChemicaMechanisoFructokinasby IsotopExchange, IsotopPartitioning, anpH Studies" Biochemistry 16, 2169-2175 (1977).

 

 F. M. RausheanW. W. Cleland, "ThSubstratanAnomeic Specificity oFructokinase," JournaoBiologicaChemistry 248, 8174-8177 (1973).

 

L. E. Cook anF. M. Raushel, "CalculatiooRetentioIndices foBenzenanBenzenDerivatives othBasis oMoleculaStructure" JournaoChromatography 65, 556-559 (1972).