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| COURSE DESCRIPTION: | A case study approach will highlight the chemical basis for transition metals in biology and medicine. A foundation of structure and bonding of coordination complexes will be followed by subjects such as cis-platin (chemotherapeutic); oxygen-carriers and storage (hemoglobin and myo-globin); nickel enzymes' active sites; etc. In the following weeks, student presentations on topics of their choice. |
| TEXTBOOK: | "Biocoordination Chemistry," David E. Fenton; Oxford University Press, (ISBN: 0-19-855773-6) "Inorganic Chemistry in Biology," Patricia C. Wilkins and Ralph G. Wilkins; Oxford University Press, UK (1997) (ISBN 0-19-855933-X) |
| REFERENCES: | "Principles of Bioinorganic Chemistry," Lippard and Berg; (ISBN: 0-935702-72-5) "Bioinorganic Chemistry," Bertini, Gray, Lippard and Valentine; (ISBN: 0-935702-57-1) "Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life," Kaim and Schwederski; (ISBN: 0-471-94369-X) "Metals in Medicine," James C. Dabrowiak; (ISBN: 978-0-470-68197-8) Online version: http://www3.interscience.wiley.com/cgi-bin/bookhome/122688104 |
| INSTRUCTOR: | Prof. Marcetta Y. Darensbourg 408 Chemistry Bldg. 845-5417 or 845-2981 Office Hours: Tuesday & Thursday 3:40 - 5 p.m. or by appointment Email: marcetta@mail.chem.tamu.edu Chemistry 489 Homepage: http://www.chem.tamu.edu/rgroup/marcetta/chem489 MYD Research Homepage: http://www.chem.tamu.edu/rgroup/marcetta |