Peer Reviewed Publications

2002~2005   2007   2008   2010   2011  2012  2013  2014  2015  2016   2017   2018   2019   2020
2021  2022





  • Yugendar R. Alugubelli, Zhi ZacharyGeng, Kai S. Yang, Namir Shaabani, Kaustav Khatua, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Jing Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu and W. R. Liu*, “A Systematic Exploration of Boceprevir-based Main Protease Inhibitors as SARS-CoV-2 Antivirals.”, Eur. J. Med. Chem., 2022, 240,114596. ARTICLE LINK


Eur J Med Chem_Yugendar


  • Ge Yu, Yuchen Qiao, Lauren R Blankenship and W. R. Liu*, “Protein Synthesis Via Activated Cysteine-Directed Protein Ligation”, Methods Mol Biol., 2022, 2530;159-167. ARTICLE LINK


Methods Mol Bio_GY 2022


  • Kai S. Yang, Sunshine Z. Leeuwon, Shiqing Xu and Wenshe R. Liu*, “Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir”, J. Med. Chem., 2022, 65, 13, 8686-8698. ARTICLE LINK


J Med Chem_2022 K Yang


  • Yuying Ma, Kai S. Yang, Zhi Zachary Geng, Yugendar R. Alugubelli, Namir Shaabani, Erol C. Vatansever, Xinyu R. Ma, Chia-Chuan Cho, Kaustav Khatua, Jin Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Su and W. R. Liu*, “A Multi-pronged Evaluation of Aldehyde-based Tripeptidyl Main Protease Inhibitors as SARS-CoV-2 Antivirals”, Eur. J. Med. Chem., 2022, 240,114570. ARTICLE LINK


Eur J Med Chem_2022


  • Brianna J. Klein, Jordan T. Feigerle, Jibo Zhang, Christopher C. Ebmeier, Lixin Fan, Rohit K. Singh, Wesley W. Wang, Lauren R. Schmitt, Thomas Lee, Kirk C. Hansen, Wenshe R. Liu, Yun-Xing Wang, Brian D. Strahl, P. Anthony Weil, and Tatiana G. Kutateladze*, “Taf2 Mediates DNA Binding of Taf14”, Nat. Commun. 2022, 13(1), 3177. ARTICLE LINK


Nat Commun_2022


  • Lei Zhang, Greg Martin, Jumaravel Mohankumar, Joshua Trae Hampton, Wenshe R. Liu and Stephen Safe*, “Reseratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells”,Mol. Pharmacol., 2022, 102(2), 80-91. doi: 10.1124/molpharm.121.000481.ARTICLE LINK


Mol pharmacol_22


  • Yang Wang, Huan Xie, Yugendar R. Alugubelli, Yuying Ma, Shiqing Xu, Jing Ma, Wenshe R. Liu and Dong Liang*, “Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of al LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies”, Pharmaceuticals. 2022, 15(6), 676. doi: 10.3390/ph15060676.ARTICLE LINK




  • Shuhua G. Li, Kai S. Yang, Lauren R. Blankenship, Chia-Chuan D. Cho, Shiqing Xu, Hongbin Wang and W. R. Liu*, “An Enhanced Hybrid Screening Approac ot Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library”, Front. Chem., 2022, 10,816575.ARTICLE LINK


Front Chem


  • Erol C. Vatansever, Kai S. Yang, Zhi Zachary Geng, Yuchen Qiao, Pingwei Li, Shiqing Xu and W. R. Liu*, “A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds”, J. Mol Biol, 2022, 167534. ARTICLE LINK


J. Mol Biol 2022_Erol


  • Yugendar R. Alugubelli, Zhi Zachary Geng, Kai S. Yang, Namir Shaabani, Kaustav Khatua, Xinyu R. Ma, Erol C. Vatansever, Chia-Chuan Cho, Yuying Ma, Lauren Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu and W. R. Liu*, “The N-Terminal Carbamate is Key to High Celluar and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors”, bioRxiv 2022. ARTICLE LINK


  • Yuying Ma, Kai S. Yang, Zhi Zachary Geng, Yugendar R. Alugubelli, Namir Shaabani, Erol C. Vatansever, Xinyu R. Ma, Chia-Chuan Cho, Kaustave Khatua, Lauren Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu and W. R. Liu*, “The P3 O-Tert-Butyl-Threonine is Key to High Celluar and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors”, bioRxiv. 2022.ARTICLE LINK


  • Chia-Chuan Cho, Lauren R. Blankenship, Xinyu Ma, Shiqing Xu and W. R. Liu*, “The Pyrrolysyl-tRNA Synthetase Activity can be Improved by a P188 Mutation that Stabilizes the Full-Length Enzyme”, J. Mol Biol, 2022, 434, 167453. ARTICLE LINK




  • Chia-Chuan Cho, Shuhua G. Li, Tyler J. Lalonde, Kai S. Yang, Ge Yu, Yuchen Qiao, Shiqing Xu and W. R. Liu*, “Drug Repurposing for the SARS-CoV-2 Papain-Like Protease”, ChemMedChem. 2022, 17, e202100455.ARTICLE LINK




  • Wenyue Cao, Chia-Chuan Dean Cho, Zhi Zachary Geng, Namir Shaabani, Xinyu R. Ma, Erol C. Vtansever, Yugendar r. Alugubelli, Yuying Ma, Sankar P. Chaki, William H. Ellenburgm Kai S. Yang, Yuchen Qiao, Robert Allen, Benjamin W. Neuman, Henry Ji, Shiqing Xu and W. R. Liu*, “Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay”, ACS Cent Sci. 2022, 8, 2, 192-204.ARTICLE LINK




  • K. S. Yang, Syuan-Ting Alex Kuo, Lauren R. Blankenshp, Zhi Zachary Geng, Shuhua G. Li, David H. Russell, Xin Yan, Shiqing Xu and W. R. Liu*, “Repurposing Halicin as Potent Covalent Inhibitor for the SARS-CoV-2 Main Protease”, Cur. Res. in Chem. Bio., 2022, 2, 100025.ARTICLE LINK


cur res in chem 2022



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  • P-H C. Chen and W. R. Liu*, “The Construction of a Genetically Encoded, Phage-Displayed Cyclic-Peptide Library”, Chapter of Peptide Conjugation, Eds. W. M. Hussein, R. J. Stephenson & I. Toth, Springer Science+Business Media, LLC., 219-230.ARTICLE LINK

Peptide Conjugation


  • Xy R. Ma, L Xu, S. Xu, B. J. Klein, Hk Wang, S. Das, K. Li, K. S. Yang, S. Sohail, A. Chapman, T. G. Kutateladze, Xb. Shi and W. R. Liu*, “Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain”, J. Med. Chem. 2021, 64, 10997-11013.ARTICLE LINK


J.medical chem


  • Y. Qiao, G. Yu, S. Z. Leeuwon and W. R. Liu*, “Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid”, Molecules, 2021, 2619.ARTICLE LINK



  • E. C. Vatansever, K. S. Yang, K. C. Kratch, A. Drelich, C.-C. Cho, K. R. Kempaiah, J. C. Hsu, D. M. Mellott, S. Xu, C.-T. K. Tseng*, and Liu W.R.*, “Bepridil is Potent Against SARS-CoV-2 In Vitro”, Proc. Natl. Acad. Sci. U. S. A., 2021, 118(10): e2012201118. ARTICLE LINK







  • K. S. Yang, X. R. Ma, Y. Ma, Y. R. Alugubell, D. A. Scott, E. C. Vatansever, A. K. Drelich, B. Sankaran, Z. Z. Geng, L. R. Blankenship, H. E. Ward, Y. J. Sheng, J. C. Hsu, K. C. Kratch, B. Zhao, H. S. Hayatshsshi, J. Liu, P. Li, C. A. Fierke*, C.-T. K. Tseng*, S. Xu* and W. R. Liu*, “A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors”, ChemMedChem, 2021,DOI: 10.1002/cmdc.202000924 (VIP paper): 10.1002/cmdc.202000924 (VIP paper). ARTICLE LINK




  • C. M. Rowlett and W. R. Liu*, “Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution Using Genetic Code Expansion in Escherichia coli”, J. Vis. Exp. 2020, DOI: 10.3791/62113.  ARTICLE LINK


  • E. C. Vatansever, J. Kang, A. Tuley, E. S. Ward E.S.* and W. R. Liu*, “An Optimal “Click” Formulation Strategy for Antibody-Drug Conjugate Synthesis”, Bioorg. Med. Chem. 2020, 28(24): 115808. ARTICLE LINK


Graphic Abstract


  • Baoyu Zhao, Pengbiao Xu, Chesley M. Rowlett, Tao Jing, Omkar Shinde, Yuanjiu Lei, a. Phillip West, Wenshe Ray Liu* & Pingwei Li*, “The Molecular Basis of Tight Nuclear Techering and Inactivation of cGAS”, Nature, 2020, ARTICLE LINK



  • K. S. Yang, X. R. M, Y. Ma Y, Y. R. Alugubelli, D. A. Scott, E. C. Vatansever, A. K. Drelich, B. Sankaran, Z. Z. Geng, L. R. Blankenship, H. E. Ward, Y. J. Shen, J. C. Hsu, K. C. Kratch, B. Zhao, H. S. Hayatshsshi, J. Liu, P. Li, C. A. Fierke, C.-T. K. Tseng, S. Xu and W. R. Liu*, “A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors”, BioRxiv, 2020, ARTICLE LINK





  • Y. Qiao, G. Yu, X. A. Wang, K. C. Kratch, S. Z. Leeuwon, W. W. Wang, J. S. Morse, and W. R. Liu*, “Expressed Protein Ligation without Intein”, J. Am. Chem. Soc. 2020, 142: 7047-7054.ARTICLE LINK



  • J. Li, S. Yuan, J. S. Qin, J. Pang, P. Zhang, Y. Zhang, Y. Huang, H. F. Drake, W. R. Liu, and H. C. Zhou*, “Stepwise Assembly of “Turn-on” Fluorescent Sensors in Multicomponent Metal-Organic Frameworks for in vitro Cyanide Detection”, Angew. Chem. Int. Ed., 2020,59, 9319-9323. DOI: 10.1002/anie.202000702. ARTICLE LINK


Nat Commu


  • J. M. Tharp, J. T. Hampton, C. A. Reed, A. Ehnbom, P. C. Chen, J. S. Morse, Y. Kurra, L. M. Perez, S. Xu, W. R. Liu "An Amber Obligate Active Site-Directed Ligand Evolution Technique for Phage Display". Nat Commun. 2020, 11(1):1392. ARTICLE LINK

Nat Commu


  • J. S. Morse, T. Lalonde, S Xu and W. R. Liu*, “Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV”, ChemBioChem, 2020, 21(5):730-738 (VIP paper). ARTICLE LINK

Nat Commu



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  • B. J. Klein, S. M. Jang, C. Lachance, W. Mi, J. Lyu, S. Sakuraba, K. Krajewski, W. W. Wang,  S. Sidoli, J. Liu, Y. Zhang, X. Wang, B. M. Warfield, A. J. Kueh, A. K. Voss, T. Thomas, B. A. Garcia, W. R. Liu, B. D. Strahl, H. Kono, W. Li, X. ShiX, J. Côté, T. G. Kutateladze."Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation". Nat Commun. 2019 Oct 17;10(1):4724. doi: 10.1038/s41467-019-12551-5. PubMed PMID: 31624313; PubMed Central PMCID: PMC6797804. ARTICLE LINK

Nat Commu

  • XS. Wang, P. C. Chen, J. T. Hampton, J. M. Tharp, C. A. Reed, S. K. Das, D. S. Wang,H. S. Hayatshahi, Y. Shen, J. Liu and W. R. Liu. "A Genetically Encoded, Phage-Displayed Cyclic-Peptide  Library". Angew Chem Int Ed Engl. 2019 Oct 28;58(44):15904-15909. doi: 10.1002/anie.201908713. Epub 2019 Sep 9. Review. PubMed PMID: 31398275; PubMed Central PMCID: PMC6803038. ARTICLE LINK

    Nature Communication

  • A. K. Ghosh, I. Samanta, A. Mondal, W. R. Liu. “Covalent Inhibition in Drug Discovery”. ChemMedChem. 2019 May 6;14(9):889-906. doi: 10.1002/cmdc.201900107. Epub 2019 Mar 26. Review. PubMed PMID: 30816012; PubMed Central PMCID: PMC6816337. ARTICLE LINK


  • W. W. Wang, M. Angulo-Ibanez, J. Lyu, Y. Kurra, Z. Tong, B. Wu, L. Zhang, V. Sharma, J. Zhou, H. Lin, Y. Q Gao, W. Li, K. F. Chua and W. R. Liu. "A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7". J Am Chem Soc. 2019 Feb 13;141(6):2462-2473. doi: 10.1021/jacs.8b12083. Epub 2019 Feb 4. PubMed PMID: 30653310; PubMed Central PMCID: PMC6812484. ARTICLE LINK

  • JACS


  • H. Yan, W. Yang, F. Zhou, X. Li, Q. Pan, Z. Shen, G. Han, A. Newell-Fugate, Y. Tian, R. Majeti, W. Liu, Y. Xu, C. Wu, K. Allred, C. Allred, Y. Sun and S. Guo. "Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1". Diabetes. 2019 Feb;68(2):291-304. doi: 10.2337/db18-0638. Epub 2018 Nov 28. PubMed PMID: 30487265; PubMed Central PMCID: PMC6341301.ARTICLE LINK



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  • B. J. Klein, K. R. Vann, F. H. Andrews, W. W. Wang, J. Zhang, Y.i Zhang, A. A. Beloglazkina, W. Mi, Y. Li, H. Li, X. Shi, A. G. Kutaeladze, B. Strahl, W. R. Liu and T. G. Kutateladze. "Structural Insights into the π-π-π Stacking Mechanism and DNA-binding Activity of the YEATS Domain", Nat Commun. 2018, Nov. 1; 9(1): 4574. doi:10.1038/s41467-018-07072-6. PubMed PMID: 30385749; PubMed Central PMCID: PMC6212594. ARTICLE LINK

    Nature Communication

  • B. T. Weinert, T. Narita, S. Satpathy, B, Srinivasan, B. K. Hansen, C. Schölz, W. B. Hamilton, B. E. Zucconi, W. W. Wang, W. R. Liu, J. M. Brickman, E. A. Kesicki, A. Lai, K. D. Bromberg, P. A. Cole, C. Choudhary. "Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome". Cell. 2018 Jun 28;174(1):231-244.e12. doi:
    10.1016/j.cell.2018.04.033. Epub 2018 May 24. PubMed PMID: 29804834; PubMed Central PMCID: PMC6078418. ARTICLE LINK


  • N. Kakkar, J. G. Perez, W. R. Liu, M. C. Jewett, W. A. van der Donk. "Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics". ACS Chem Biol. 2018 Apr 20;13(4):951-957. doi: 10.1021/acschembio.7b01024. Epub 2018 Feb 21. PubMed PMID: 29439566; PubMed Central PMCID: PMC5910287. ARTICLE LINK

    Del cell 2018

  • J. M. Tharp, W. R. Liu. "Using Amber and Ochre Nonsense Codons to Code Two Different Noncanonical Amino Acids in One Protein Gene". Methods Mol Biol. 2018;1728:147-154. doi: 10.1007/978-1-4939-7574-7_9. PubMed PMID: 29404996. ARTICLE LINK

  • J. Huan, C. J. Mousley, L. Dacquay, N. Maitra, G. Drin, C. He, ND Ridgway, A. Tripathi, M. Kennedy, BK Kennedy, WS Liu, K. Baetz, M. Polymenis, V. A. Bankaitis. "A Lipid
    Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems", Dev Cell. 2018 Feb 5; 44(3), 378-391.e5. doi: 10.1016/j.devcel.2017.12.026. Epub 2018 Jan 27. PubMed PMID: 29396115; PubMed Central PMCID: PMC6444186. ARTICLE LINK



Del cell 2018



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  • Jeffery M. Tharp and Wenshe R. Liu*. "Genetic Code Expansion: Synthetases Pick Up the PACE", Nat Chem Biol., 2017, 13(12), 1205-1206. doi:10.1039/nchembio.2516. ARTICLE LINK

    2017 Nat Chem Biol

  • Vangmayee Sharma, Yu Zeng, W. Wesley Wang, Yuchen Qiao, Yadagiri Kurra and Wenshe R. Liu*. "Evolving the N-Terminal Domain of Pyrrolysyl-tRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids", ChemBioChem., 2017, 18, 1-6. doi:10.1002/cbic.201700268 ARTICLE LINK

    ChemBioChem 2017

  • Jeffery M. Tharp, Andreas Ehnbom and Wenshe R. Liu*. "Structure, Function, and Applications", RNA Biol., 2017 Aug 24:1-12.doi:10.1080/15476286.2017.1356561 ARTICLE LINK

RNA Biol 2017_Tharp

  • Zhipeng A. Wang and Wenshe R. Liu*. "Proteins with Site-Specific Lysine Methylation", Chem. Eur. J., 10.1002/chem.201701655. ARTICLE LINK

Chem Eur J-10.1002


  • Mingzhao Zhu, Wayne D. Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G. Hull, Sung Wook Chok, Robyn D. Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T. Wilson, Ju Anne Yau, James T. Moore, Caitlen B. Walker, James C. Sacchettini, Wenshe R. Liu, Stephan A. Sieber, Jeffrey W. Smith and Daniel Romo*. "A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-orlistat Hybrids", Bioorg. Med. Chem., 2017, 25, 2901-2916. ARTICLE LINK

  • Bioorg Med Chem 2017

  • Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu and Qing Lin*, and Wenshe R. Liu*. "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking", J. Am. Chem. Soc., 2017, 139, 6078-6081. ARTICLE LINK

  • jacs_2017_139_6078


  • Zhipeng A. Wang, Yadagir Kurra, Xin Wang, Yu Zeng, Yan-Jiun Lee, Vangmayee Sharma, Hening Lin, Susie Y. Dai*, and Wenshe R. Liu*. "A Versatile Approach for Site-Specific Lysine Acylation in Proteins", Angew. Chem. Int. Ed., 2017, 56, 1643-1647. ARTICLE LINK

  • Angew chem Int Ed_2017_56_1643


  • Zhipeng A. Wang, Yu Zeng, Yadagir Kurra, Xin Wang, Jeffrey M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu*. "A Genetically Encoded Allysine for the Synthesis of Proteins with Site-specific Lysine Dimethylation", Angew. Chem. Int. Ed., 2017, 56, 212-216. ARTICLE LINK





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  • Vangmayee Sharma, Yane-Shih Wang, and Wenshe R. Liu, "Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics”, ACS Chem Biol. 2016, 11, 3305-3309. ARTICLE LINK

ACS Chem Biol 2016_11_3305


  • Yan-Jiun Lee, M. J. Schmidt, Jeffery M. Tharp, Annemarie Weber, Amber L. Koenig, Hong Zheng, Jianmin Gao, Marcey L. Waters, Daniel Summerer,* and Wenshe R. Liu* "Genetically Encoded Fluorophenylalanines Enable Insights into the Recognition of Lysine Trimethylation by an Epigenetic Reader" Chem. Commun., 2016, 52, 12606-12609.ARTICLE LINK



  • Wang, Wesley Wei; Zeng, Yu; Wu, Bo; Deiters, Alexander and Liu, Wenshe*, "A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes", ACS Chem. Biol., 2016, 11, 1973-1981. ARTICLE LINK



  • Hsu, Willie W.; Wu, Bo and Liu, Wenshe R.*, "Sirtuins 1 and 2 Are Universal Histone Deacetylases", ACS Chem. Biol., 2016, 11, 792-799. ARTICLE LINK



  • Tharp, Jeffery M. and Liu, Wenshe R.*, "The 'π-Clamp' Offers a Novel Strategy for Site-selective Protein Modification", ChemBioChem, 2016, 17, 883-885. ARTICLE LINK



  • Lee, Yan-Jiun; Kurra, Yadagiri and Liu, Wenshe R.*, "Phospha-Michael Addition as a New Click Reaction for Protein Functionalization", ChemBioChem, 2016, 17, 456-461. ARTICLE LINK


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  • He, Tao; Gershenson, Anne; Eyles, Stephen J.; Lee, Yan-Jiun; Liu, Wenshe R.; Wang, Jiangyun; Gao, Jianmin; and Roberts, Mary F.*, "Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membran Insertion", J. Biol. Chem, 2015, 290, 19334-19342. ARTICLE LINK
  • Bindman, Noah A; Boeica, Silvia C.; Liu, Wenshe R.; van der Donk, Wilfred A.*, "Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid", J. Am. Chem. Soc., 2015, 137, 6975-6978. ARTICLE LINK



  • Xin, X; Liu, W. R; Sun, L.*, "Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification", Mol. Med. Rep., 2015, 11, 3774-3779. ARTICLE LINK
  • Guan, Dongli; Kurra, Y; Liu, W. R.; Chen, Zhilei*, "A click chemistry approach to site-specific immobilization of a small laccase enables efficient direct electron transfer in a biocathode", Chem. Commun., 2015, 51, 2522-2525. ARTICLE LINK



  • Piscotta, Frank J.; Tharp, Jeffery M.; Liu, W. R.; Link, A. James*, "Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids", Chem. Commun., 2015, 51, 409-412. ARTICLE LINK




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  • Wang, Xiaoyan Aria; Kurra, Y; Huang, Y; Lee, Y-J; Liu, W. R.*, E1-Catalyzed Ubiquitin C-Terminal Amidation for the Facile Synthesis of Deubiquitinase Substrates", ChemBioChem, 2014, 15, 37-41. ARTICLE LINK



  • Lee, Y.-J; Kurra, Y; Yang, Y; Torres-Kolbus, J; Deiters, A; Liu, W. R.*, 'Correction:"Genetically Encoded Unstrained Olefins for Live Cell Labeling with Tetrazine Dyes"', Chem. Commun., 2014, 50, 13396-133968. ARTICLE LINK


  • Lee, Y.-J; Kurra, Y; Yang, Y; Torres-Kolbus, J; Deiters, A; Liu, W. R.*, "Genetically Encoded Unstrained Olefins for Live Cell Labeling with Tetrazine Dyes", Chem. Commun., 2014, 50, 13085-13088. ARTICLE LINK



  • Kurra, Y; Odoi, K. A; Lee, Y.-J; Yang, Y; Lu, T; Wheeler, S. E; Torres-Kolbus, J; Deiters, A; Liu, W. R.*, "Two Rapid Catalyst-Free Click Reactions for In Vivo Protein Labeling of Genetically Encoded Strained Alkene/Aldyne Functionalities", Bioconjugate Chemistry, 2014, 25, 1730-1738. ARTICLE LINK



  • Zeng, Yu; Wang, W; Liu, W. R.*, "Towards Reassigning the Rare AGG Codon in Escherichia Coli", ChemBioChem, 2014, 15, 1750-1754. ARTICLE LINK
  • bcb_2014-15_1750

  • Liu, W. R., "Reports from the Chemical Biology of Texas Symposium at the 69th Southwest Regional Meeting of the American Chemical Society", ACS Chemical Biology, 2014, 9, 319-322. ARTICLE LINK
  • Wang, Xiaoshan Shayna; Lee, Yan-Jiun; Liu, W. R*, "The nitrilimine-alkene cycloaddition is an ultra rapid click reaction", Chem. Commum., 2014, 50, 3176-3179. ARTICLE LINK



  • Tuley, A., Lee, Y.-J., Wu, Bo., Wang, Z. U. & Liu, W.R.*, "A genetically encoded aldehyde for rapid protein labelling",, J. Roayl Soc. of Chem. Chem. Commun. 2014, 50, 7424-7426. ARTICLE LINK



  • Tuley, A., Wang, Y.-S., Fang, X., Kurra, Y., Rezenom, Y. H. & Liu, W.R.*, "The genetic incororation of thirteen novel non-canonical amino acids", Chem. Commun., 2014, 50, 2673-2675. ARTICLE LINK



  • Tharp, J. M., Wang, Y.-S., Lee, Y.-J., Yang, Y. & Liu, W.R.*, "Genetic Incorporation of Seven ortho-Substituted Phenylalanine Derivatives", ACS Chem. Biol., 2014, 9 (4), 884-890. ARTICLE LINK



  • Wan, W., Tharp, J. M., & Liu, W.R., “Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool”, Biochemica et Biophysica Acta 2014, 1844, 1059-
  • Liu, W.R.*, "Reports from the Chemical Biology of Texas symposium at the 69th Southwest Regional Meeting of the American Chemical Society", ACS Chem. Biol. 2014, 9, 319-322. ARTICLE LINK


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  • Hladilková, Jana, Heyda, J., Rembert, K. B., Okur, H. I., Kurra, Y., Okur, H. I., Liu, W. R., Hilty, C., Cremer, P. S., Jungwirth, P.*, “Effects of End-Group Termination on Salting-Out Constants for Triglycine”, J. Phys. Chem. Lett. 2013, 4, 4069-4073. ARTICLE LINK



  • Paterová, Jana, Rembert, K. B., Heyda, J. Kurra, Y., Okur, H. I., Liu, W. R., Hilty, C., Cremer, P. S., Jungwirth, P.*, “Reversal of the Hofmeister Series: Specific Ion Effects on Peptides”, J. Phys. Chem. B, 2013, 117, 8150-8158. ARTICLE LINK



  • Lee, Y.-J. C., Wu, Bo., Raymond, J. E., Zeng, Y., Fang, X., Wooley, K. L., & Liu, W.R.*, “A Genetically Encoded Acrylamide Functionality”, ACS Chem. Biol., 2013, 8, 1664-1670. ARTICLE LINK



  • Wang, Y.-S., Fang, X., Chen, H.-Y., Wu, B., Wang, Z.U., Hilty, C.B., & Liu, W.R.*, “Genetically Encoding Twelve meta-Substituted Phenylalanine Derivatives with Diverse Bioorthogonal Functionalities Using a Single Pyrrolysyl-tRNA Synthetase Mutant”, ACS Chem. Biol., 2013, 8, 405-415. ARTICLE LINK



  • Odoi, K.A., Huang Y., Rezenom, Y.H. & Liu, W.R.*, "Nonsense and Sense Cuppression Abilities of Original and Derivative Methanosarcina mazei Pyrrolysyl-tRNA Synthetase-tRNAPyl Pairs in the Escherichia coli BL21 (DE3) Cell Strain", PLOS One, 2013, 8, 357035. ARTICLE LINK


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  • O’Donoghue, P, Prat, L., Heinemann, I., Ling, J., Odoi, K.A., Liu, W.R.* & Soll, D.*, “Near-cognate Suppression of Amber, Opal, and Quadruplet Codons Compete with Aminoacyl-tRNAPyl for Genetic Code Expansion”, FEBS Lett., 2012, 21, 393103937. (*co-corresponding authors). ARTICLE LINK

  • Wan, W, Wang, Y.-S., & Liu, W.R.*, “Genetically Encoding Bioorthogonal Functional Groups for Siteselective Protein Labeling”, Organic Chem. Curr. Res., 2012, 1:e111, DOI: 10.4172/2161-0401.1000e111. ARTICLE LINK

  • Wang, Z.U., Wang, Y.-S., Pai, P.-J., Russell, W.K., Russell, D.H. & Liu, W.R.*, “A Facile Method to Synthesize Histones with Posttranslational Modification Mimics”, Biochemistry, 2012, 51:5232-5234. ARTICLE LINK



  • Wang, Y.-S., Fang, X., Wallace, A.L., Wu, B. & Liu, W.R.*, “A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant Has a Broad Substrate Specificity”, J. Am. Chem. Soc., 2012, 134: 2950-2953.ARTICLE LINK



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  • Weinert, B.T., Wagner, S.A., Horn, H., Henriksen, P., Liu, W.R., Olsen, J.V., Jensen, L.J. & Choudhary, C.*, “Proteome-wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation”, Sci. Signal, 2011, 4: ra48.ARTICLE LINK
  • Wang, Y.-S., Russell, W.K., Wang, Z., Wan, W., Dodd L.E., Pai, P.-J., Russell, D.H., & Liu W.R.*, “The De Novo Engineering of Pyrrolysyl-tRNA Synthetase for Genetic Incorporation of L-phenylalanine and Its Derivatives”, Mol. BioSyst., 2011, 7: 714-717. ARTICLE LINK



  • Liu, W.R.*, Wang, Y.-S. & Wan, W., “Synthesis of Proteins with Defined Posttranslational Modifications Using the Genetic Noncanonical Amino Acid Incorporation Approach”, Mol. BioSyst., 2011, 7: 38-47.ARTICLE LINK



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  • Wang, Y.-H., Wu, B., Wang, Z., Huang, Y., Wan, W., Russell, W.K., Pai, P.-J., Russell, D.H. & Liu, W.R.*, “A Genetically Encoded Photocaged Nε-methyl-L-lysine” Mol. Biosyst., 2010, 6: 1557-1560. This was an invited submission and featured on Molecular BioSystems 2010 Emerging Investigators Issue. ARTICLE LINK



  • Wan, W., Huang, Y., Wang, Z., Russell, W.K., Pai, P.-J., Russell, D.H. & Liu, W.R.*, “A Facile System for Genetic Incorporation of Two Different Noncanonical Amino Acids into One Protein in Escherichia coli”, Angew. Chem. Int. Ed., 2010, 49: 3211-3214. Chosen as a “Hot Paper” by the Editors for its importance in a rapidly evolving field of high current interest and announced in the journal’s press release.ARTICLE LINK



  • Huang, Y., Russell, W.K., Wan, W., Pai, P.-J., Russell, D.H. & Liu, W.*, “A convenient Method for Genetic Incorporation of Multiple Noncanonical Amino Acids into One Protein in Escherichia coli”. Mol. BioSyst. 2010, 6: 683-686. ARTICLE LINK



  • Huang, Y., Wan, W., Russell, W.K., Pai, P.-J., Wang, Z., Russell, D.H. & Liu, W.*, “Genetic Incorporation of An Aliphatic Keto-containing Amino Acid into Proteins for Their Site-specific Modificaiton”. Bioorg. Med. Chem. Lett. 2010, 20: 878-880. ARTICLE LINK



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  • Brustad, E., Bushey, M.L., Lee, J.W., Groff, D., Liu W. & Schultz, P.G.* “A Genetically Encoded Boronate Containing Amino Acid” Angew. Chem. Int. Ed. Engl., 2008, 47: 8220-8223. ARTICLE LINK
  • Graziano, J.J., Liu, W., Perera, R., Geierstanger, B.H., Lesley, S.A., & Schultz, P.G. “Selecting Folded Proteins from a Library of Secondary Structural Elements”, J. Am. Chem. Soc., 2008, 130: 176-185 ARTICLE LINK


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  • Tippmann, E.M.­­­+, Liu, W.+, Summerer, D., Geierstanger, B., Mack, A.V., & Schultz, P.G.*, “A Genetic Encoded Diazirine Photocrosslinker in Escherichia coli”, ChemBioChem, 2007, 8: 2210-2214 (+equally contributing authors) ARTICLE LINK
  • Liu, C.C., Braustad, E., Liu, W.* & Schultz, P.G.*, “Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed with Thrombin”, J. Am. Chem. Soc., 2007, 129: 10648-10649 (*corresponding authors in this paper)ARTICLE LINK
  • Liu, W., Brock, A., Chen, S., Chen, S. & Schultz, P.G.*, “The Genetic Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells”, Nat. Methods. 2007, 4: 239-44. ARTICLE LINK
  • Xie, J., Liu, W., & Schultz, P.G.* “A Genetic Encoded Bidentate, Metal Ion Binding Amino Acid”,Biochem Angew. Chem. Int. Ed., 2007, 46: 9239-9242. ARTICLE LINK
  • Liu, W., Alfonta, L., Mack, A.V. & Schultz, P.G.* “Structural Basis for the Recognition of p-Benzoyl-L-phenylalanyl by Evolved Aminoacyl-tRNA Synthetases”, Angew. Chem. Int. Ed., 2007, 46: 6073-6075. ARTICLE LINK


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  • Liu, W., Peterson, P.E., Langston, J.A., Jin, X., Zhou, X., Fisher, A.J. & Toney, M.D.* “Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coli g-Aminobutyrate Aminotransferase”, Biochemistry 2005, 44: 2982-92.ARTICLE LINK
  • 2005_44_2982


  • Fogle, E.J., Liu, W., Keller, J. & Toney, M.D.* “Role of Q52 in the Decarboxylation and Transamination of Dialkylglycine Decarboxylase”, Biochemistry 2005, 44: 16392-404.ARTICLE LINK
  • Liu, W., Peterson, P.E., Carter, R.J., Zhou, X., Langston, J.A., Fisher, A.J. & Toney, M.D. “Crystal Structures of Unbound and Aminooxyacetate-bound Escherichia coli g‑Aminobutyrate Aminotransferase. Biochemistry 2004, 43: 10896-905. ARTICLE LINK
  • Liu, W. & Toney, M.D. “Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase”, Biochemistry 2004, 43: 4998-5010.ARTICLE LINK
  • Liu, W., Rogers, C.J., Fisher, A.J. & Toney, M.D. “Aminophosphonate inhibitors of dialkylglycine decarboxylase: Structural basis for slow binding inhibition”, Biochemistry 2002, 41: 12320-28. ARTICLE LINK



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