Biophysical and Bioinorganic Chemistry
Iron Metabolism in Cells
Mechanistic Modeling of Biological Processes
EPR and Mössbauer Spectroscopy
We isolate organelles from yeast cell to understand metal trafficking at a granular level. Mitochondria are of particular interest because they are the 'hub' of iron metabolism.
LMPs consist of small metal complexes with nonproteinaceous ligands. We are using liquid-chromatography interfaced with inductively-coupled plasma mass spectrometry (LC-ICP-MS) to detect, identify, and characterize these pools.
We have recently embarked on a project involving characterization of NTBI (non-transferrin bound iron) in the plasma of Hemochromatosis Mice.
We are developing ordinary-differential-equations-based models that describe the kinetics of iron trafficking and regulation in yeast cells.