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Dr. David H. Russell
Dr. Shane E. Tichy
Dr. William K. Russell
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  Department of Chemistry
  Texas A&M University




 

 

 

 

Dr. David H. Russell


Professor
Ph. D., University of Nebraska

Analytical and Biological Mass Spectrometry

Director, Laboratory of Biological Mass Spectrometry

Ofc: (979) 845-3345
Fax: (979) 845-9485


Russell@Mail.Chem.Tamu.Edu
 



 

Overview

Research activities in my group are in the general area of mass spectrometry and gas-phase ion chemistry. The research projects include biological chemistry, fundamental gas-phase ion chemistry, and instrumentation development, especially laser-mass spectrometry instruments. The biological mass spectrometry research program focuses on studies of peptides and proteins as well as the development of more versatile and sensitive methods for structural characterization. Efforts are underway to extend these methods to characterization of DNA. Matrix-assisted laser desorption ionization (MALDI) is the primary ionization method used in this research and time-of-flight (TOF) and Fourier-transform ion cyclotron resonance (FTICR) are the mass analyzers. Novel instrumentation plays an increasingly important role in biological mass spectrometry. We are actively pursuing new instrument methods centered around the TOF and FTICR instruments. The instrument inventory includes five TOF instruments, two magnetic sector instruments, and a quadrupole instrument for electrospray ionization. In addition, two novel tandem TOF and two state-of-the-art FTICR instruments are dedicated to my research program.

Scholarly Publications

Refereed Journals

1) "Possible Polar Cycloadditions: Mechanisms of the Reactions of Ionized 1,3-Butadiene and Ethene and Ionized Furan and 1,3-Butadiene," M. L. Gross, D. H. Russell, R. Phongbetchara, and P. H. Lin, Adv. Mass Spectrometry 1977, 7, 129.

2) "Ion-Molecule Reaction Chemistry of Various Gas-Phase C6H6 Radical Cations," M. L. Gross, D. H. Russell, R. J. Aerni, and S. A. Bronczyk, J. Am. Chem. Soc. 1977, 99, 3603.

3) "Keto-Enol Tautomerism of Gas-Phase Ions: Structure of Reactive C6H6O Radical Cations," D. H. Russell, M. L. Gross, and N. M. M. Nibbering, J. Am. Chem. Soc., 1978, 100, 6122.

4) "The Chemistry of C6H6O Radical Cations: A Study of Rearrangement Reactions of Halogen Substituted Ethyl Phenyl Ethers," D. H. Russell, M. L. Gross, J. van der Greef, and N. M. M. Nibbering, Org. Mass Spectrom., 1979, 14, 474.

5) "The Electrocyclic Ring-Opening of the Cyclobutene Radical Cation," M. L. Gross and D. H. Russell, J. Am. Chem. Soc., 1979, 101, 2082.

6) "Decomposition of the 1,3-Butadiene Radical Cation on the Microsecond to Picosecond Timescale," D. H. Russell, M. L. Gross, J. van der Greef, and N. M. M. Nibbering, J. Am. Chem. Soc., 1979, 101, 2086.

7) "Chemical Properties of the Fulvene Radical Cation," D. H. Russell and M. L. Gross, J. Am. Chem. Soc., 1980, 102, 6279.

8) "The Design and Performance Evaluation of a New High Performance Mass-Analyzed Ion Kenetic Energy (MIKE) Spectrometer," D. H. Russell, D. H. Smith, R. J. Warmack, and L. K. Bertram, Int. J. Mass Spectrom. Ion Phys., 1980, 35, 381.

9) "Structural Determination of [C7H7O]+ Cations in the Gas Phase by Ion Cyclotron Resonance Spectrometry," C. J. Cassidy, B. S. Freiser, and D. H. Russell, Org. Mass Spectrom., 1983, 18, 378.

10) "The Structure of Decomposing [C7H7O]+ Ions: Benzyl versus Tropylium Ion Structures," D. H. Russell, B. S. Freiser, E. H. McBay, and D. C. Canada, Org. Mass Spectrom., 1983, 18, 474.

11) "High-Energy Collision-Induced Dissociation with Fourier Transform Mass Spectrometry," D. L. Bricker, T. A. Adams, and D. H. Russell, Anal. Chem., 1983, 55, 2417.

12) "Cesium Ion Desorption Ionization with Fourier Transform Mass Spectrometry," M. E. Castro and D. H. Russell, Anal. Chem., 1984, 56, 578.

13) "Laser-Ion Beam Photodissociation Studies of C3H3Br+ and C3H3C1+", R.E. Krailler, D.H. Russell, Int. J. Mass Spectrom Ion Proc., 1985, 66, 339-351.

14) "Laser-Ion Beam Photodissociation Studies of C6H6+ Radical Cations: The 2,4-Hexadiyne System," R. E. Krailler, D. H. Russell, M. F. Jarrold, and M. T. Bowers, J. Am. Chem. Soc., 1985, 107, 2346.

15) "Laser-Ion Beam Photodissociation Studies of C4H4 Radical Cations," R. E. Krailler and D. H. Russell, Org. Mass Spectrom., 1985, 20, 606.

16) "Formation of Ionic Transition Metal Carbonyl Cluster Fragments by Ion Molecule Reactions: I. The Cr(CO)6 and Fe(CO)5 Systems," D. A. Fredeen and D. H. Russell, J. Am. Chem. Soc., 1985, 107, 3762.

17) "Desorption Ionization of CsI by FTMS," M. E. Castro, D. H. Russell, Anal. Chem., 1985, 57, 2290.

18) "Differentiating Geometric Isomers by Laser-Ion Beam Photodissociation, R. E. Krailler, and D. H. Russell, Anal. Chem., 1985, 57, 1211.

19) "Cesium Desorption Ionization Studies of ß-Cyclodextrin by Fourier Transform Mass Spectrometry," M. E. Castro, L. M. Mallis, and D. H. Russell, J. Am. Chem. Soc., 1985, 107, 5652.

20) "Collisional Activation by Fourier Transform Mass Spectrometry: A Study of Target Gas Excitation," D. H. Russell and D. L. Bricker, Anal. Chim. Acta., 1985, 178, 117.

21) "Measurement of Positional Isotope Exchange Rates in Enzyme-Catalyzed Reactions by Fast Atom Bombardment Mass Spectrometry: Application to Argininosuccinate Synthetase", L.W. Hilscher, C.D. Hanson, D.H. Russell, F.M. Raushell, Biochem., 1985, 24, 5888.

22) "Determination of 18O Incorporation in ATP by Enzymatic Reactions by Fast-Atom Bombardment Mass Spectrometry and 31NMR," L. W. Hilsher, C. D. Hanson, F. M. Raushel and D. H. Russell, J. Biochem., 1985, 24, 5888.

23) "Synthesis and Structure of Distibene and Bridging Stibinidene Iron Complexes," A. H. Cowley, N. C. Norman, D. L. Bricker, and D. H. Russell, J. Am. Chem. Soc., 1985,107, 8211.

24) "Formation of Ionic Transition Metal Carbonyl Cluster Fragments by Ion Molecule Reactions. II. The Co(CO)3NO and Ni(CO)4 Systems," D. A. Fredeen and D. H. Russell, J. Am. Chem. Soc., 1986, 108, 1860.

25) "Detection of Mass 16241 Ions by Fourier-Transform Mass Spectrometry", I. J. Amster, F.W. McLafferty, M.E. Castro, D.H. Russell, R.B. Cody, Jr., and S. Ghaderi, Anal. Chem., 1986, 58, 485.

26) "A Study of Target Gas Excitation Accompanying Collisional Activation of Large Polyatomic Ions," D. L. Bricker and D. H. Russell, J. Am. Chem. Soc., 1986, 108, 6174.

27) "Fast-Atom Bombardment - Tandem Mass Spectrometry Studies of Organo-Alkali Metal Ions of Small Peptides," L. M. Mallis, F. M. Raushel, and D. H. Russell, Anal. Chem., 1986, 58, 1076.

28) "Ion Molecule Reactions of Cr(CO)5- with O2: Unusual Chemistry and Reactivity Dependence on Temperature," D. L. Bricker and D. H. Russell, J. Am. Chem. Soc., 1987, 109, 3910.

29) "Laser-Ion Beam Photodissociation Studies of Ionic Cluster Fragments of Transition Metal Carbonyls," R. E. Tecklenburg and D. H. Russell, J. Am. Chem. Soc., 1987, 109, 7654.

30) "Tandem Quadrupole Fourier-Transform Mass Spectrometry of Oligopeptides and Small Proteins," D. F. Hunt, J. Shabanowitz, J. R. Yates, III, N-Z. Zhu. D. H. Russell, and M. E. Castro, Proc. Natl. Acad. Sci., 1987, 84 , 620.

31) "The Chemistry of Glycerol/Alkali Metal Halide Complex Ions Studied by Fast- Atom Bombardment - Tandem Mass Spectrometry," L. M. Mallis and D. H. Russell, Int. J. Mass Spec. Ion Proc., 1987, 78, 620.

32) "Some General Aspects of the Chemistry of Organo-Alkali Metal Ions. An Overview of Recent Work", L.M. Mallis, D.H. Russell, Int. J. Mass Spectrom Ion Proc., 1987, 78, 147-178.

33) "Differentiation of Isotopically Labelled Nucleotides by Using Fast-Atom Bombardment -Tandem Mass Spectrometry," L. M. Mallis and D. H. Russell, Anal. Chem., 1987, 59, 980.

34) "Formation of Ionic Transition-Metal Carbonyl Cluster Fragments by Ion-Molecule Reactions. 3. The Heteronuclear Systems", D.A. Fredeen and D.H. Russell, J. Am. Chem. Soc., 1987, 109, 3903.

35) "A Study of the Ion-Molecule Reactions of the Cr(CO)5- Anion with Oxygen", D.L. Bricker, D.H. Russell, J. Am. Chem. Soc., 1987, 109, 3910.

36) "A Photodissociation Study of 1,3-Butadiene," L. S. Hann, R. E. Krailler, and D. H. Russell, J. Chem. Phys., 1988, 89, 889.

37) "Laser-Ion Beam Photodissociation Studies of Ionic Cluster Fragments of Iron Carbonyls; Fex(CO)y+ (x= 1-3; y= 0-6)", R.E. Tecklenberg, Jr., D.L. Bricker, D.H. Russell, Organomet., 1988, 7, 2506.

38) "Fast-Atom Bombardment Tandem Mass Spectrometry Studies of Organo-Alkali- Metal Ions of Small Peptides. Competitive Interaction of Sodium with Basic Amino Acid Substituents," D. H. Russell, E. S. McGlohon, and L. M. Mallis, J. Am. Chem. Soc., 1988, 60, 1818.

39) "High Resolution Ion Partitioning Techniques by Phase-Specific Ion Excitation for FT-ICR," C. D. Hanson, E. L. Kerley, and D. H. Russell, Anal. Chem., 1989, 61, 83.

40) "Mass and Energy Selective Ion Partitioning in a Two-Section FT-ICR Cell," E. L.Kerley and D. H. Russell, Anal. Chem., 1989, 61, 53.

41) "Evaluation of Pulsed Fast-Atom Bombardment Ionization for Increased Sensitivity of Tandem Mass Spectrometry," R. E. Tecklenburg, Jr., M. E. Castro, and D. H. Russell, Anal. Chem., 1989, 61, 153.

42) "Ion Detection by Fourier Transform Ion Cyclotron Resonance: The Effect of Initial Radial Velocity on the Coherent Ion Packet", C.D. Hanson, E.L. Kerley, M.E. Castro, D.H. Russell, Anal. Chem., 1989, 61, 2040.

43) "Phase Synchronization of an Ion Ensemble by Frequency Sweep Excitation in Fourier Transform Ion Cyclotron Resonance", C.D. Hanson, M.E. Castro, D.H. Russell, Anal. Chem., 1989, 61, 2130.

44) "Axial Magnetic Inhomogeneities at Low Energy Ion Injection in Fourier Transform Ion Cyclotron Resonance Spectrometry," E. L. Kerley, C. D. hanson, M. E. Castro, and D. H. Russell, Anal. Chem., 1989, 61, 2528.

45) "The Utility of a Biased Activation Cell for Laser-Ion Beam Photodissociation Studies," R. E. Tecklenburg, Jr., L. Sellers-Hann, and D. H. Russell, Int J. Mass Spectrom. Ion Proc., 1989, 87, 111.

46) "Laser-Ion Beam Photodissociation Studies of Model Amino Acids and Peptides," R. Tecklenburg, Jr., M. N. Miller, and D. H. Russell, J. Am. Chem. Soc., 1989, 111, 1161.

47) "Field-Corrected Ion Cell for Ion Cyclotron Resonance," C. D. Hanson, M. E. Castro, E. L. Kerley, and D. H. Russell, Anal. Chem., 1990, 62, 520.

48) "LaB6 Electron Emitter for Electron Impact and Electron-Induced Dissociation Fouier Transform Ion Cyclotron Resonance Spectrometry," E. L. Kerley, C. D. Hanson, and D. H.Russell, Anal. Chem., 1990, 62, 409.

49) "High Precision Arbitrary Waveform Generator for Ion Selection in FT-ICR," C. D. Hanson, M. E. Castro, E. L. Kerley, and D. H. Russell, Anal Chem., 1990, 62, 1352.

50) "Ligand Fluxionality and the Formation of Cationic Iron Carbonyl Clusters," E. L. Kerley and D. H. Russell, J. Am. Chem. Soc., 1990, 112, 5959.

51) "Ion-Molecule Reaction Chemistry of Ionic Transition-Metal Carbonyl Cluster Fragments. 1. Ligand Exchange Reactions of Cr2(CO)y+ Ions," L. S. Hann and D. H. Russell, J. Am. Chem. Soc., 1990, 112, 5953.

52) "Detection of Femtomole and Sub-femtomole Levels of Peptides by Tandem Magnetic Sector/Reflectron Time-of-Flight Mass Spectrometry and Matrix-Assisted Laser Desorption Ionization," F. Strobel, T. Solouki, M. A. White, and D. H. Russell, J. Am. Chem. Soc., 1991, 2, 268R.

53) "Dissociative Chemistry of Ionic Transition Metal Cluster Fragments," F. S. Strobel and D. H. Russell, J. Clus. Sci., 1991, 2, 57.

54) "Electronegativity and the Reactions of XFe+ (X=Cl, Br, I) with Fe(CO)5," Eric L. Kerley and David H. Russell, Int. J. Mass Spectrom Ion Processes, 1991, 110, 215.

55) "Gas Phase Ion-Molecule Charge Exchange Reactions of Fe+ With Fe(CO)5, Observation of Higher Lying Metastable Electronic States," J. V. B. Oriedo and D.H. Russell, J. Phys. Chem., 1992, 96, 5314-5319.

56) "Neutral-Ion Correlation Measurements: A Novel Tandem Mass Spectrometry Data Acquisition Mode for Tandem Magnetic Sector/Reflectron Time-of-Flight Instruments," F. H. Strobel, L. M. Preston, K. S. Washburn and D. H. Russell, Anal. Chem., 1992, 64, 754.

57) "Are Proton Transfer Reactions of Excited States Involved in UV Laser Desorption Ionization?" D. H. Russell, M. A. White, and T. Solouki, Org. Mass Spectrom, 1992, 27, 827-830.

58) "Laser Desorption Studies of High Mass-Biomolecules in Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry", T. Solouki, D. H. Russell, Proc. Natl. Acad. Sci., USA, 1992, 89, 5701-5705.

59) "Isotopic Labelling Investigation of the Oxygenation of Ni-Bound Thiolates by Molecular Oxygen" P. J. Farmer; T. Solouki, D. K. Mills, T. Soma, D. H. Russell, J. H. Reibenspies, M. Y. Darensbourg, J. Am. Chem. Soc., 1992, 114, 4601-4605.

60) "Signal-to-Noise Enhancement of Neutral-Ion Correlation Measurements for Tandem Time-of-Flight Mass Spectrometry" F. H. Strobel; D. H. Russell, Anal. Chem., 1992, 64, 2879-2881.

61) "Ion-Molecule Reaction Chemistry of Fe+ with NO: Excited-versus Ground-State Reactions" J. V. B. Oriedo; D. H. Russell J. Am. Chem. Soc., 1993, 115, 8376-8381.

62) "Structural Mass Spectrometry of Matrix-Assisted Laser Desorbed Biomolecules by Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry: Photoionization and Photofragmentation" T. Solouki; D. H. Russell, Appl. Spectros. 1993, 47, 211.

63) "Divergent Pathways for the Addition of Dioxygen to Sulfur in Nickel cis-Dithiolates: An Isotopomeric Analysis" P.J. Farmer; T. Solouki, T. Soma, D.H. Russell, M.Y. Darensbourg, Inorg. Chem., 1993, 32, 4171-4172.

64) "Liquid Sample Introduction for Matrix-Assisted Laser Desorption Ionization" K.K. Murray; D.H. Russell, Anal. Chem., 1993, 65, 2534-2537.

65) "Reproducibility and Quantitation of Matrix-assisted Laser Desorption Ionization Mass Spectrometry: Effects of Nitrocellulose on Peptide Ion Yields" L.M. Preston; K.K. Murray, D.H. Russell, Biol. Mass Spectrom., 1993, 22, 544-550.

66) "Matrix-Assisted Laser Desorption Ionization of Aerosols: The Ionization Mechanism", K.K. Murray, D.H. Russell, Laser Ablation: Mechanisms and Applications-II, J.C. Miller and D.B. Geohegan (Ed.), AIP Conference Proceedings, 1994, 288.

67) "Aerosol Matrix-Assisted Laser Desorption Ionization Mass Spectrometry" K.K. Murray; D.H. Russell, J. Am. Soc. Mass Spectrom., 1994, 5, 1-9.

68) "Fragmentation of Vitamin B12 During 337 nm Matrix Assisted Laser Desorption Ionization" G.R. Kinsel; L.M. Preston, D.H. Russell, Biol. Mass Spectrom., 1994,23, 205-211.

69) "Detection of High Mass Biomolecules in Fourier-Transfer Ion Cyclotron Resonance Mass Spectrometry : Theoretical and Experimental Investigations" T. Solouki; K.J. Gillig; D.H. Russell, Anal. Chem., 1994,66, 1583-1587.

70) "Mass Measurement Accuracy of Matrix-Assisted Laser Desorbed Biomolecules" T. Solouki; K.J. Gillig; D.H. Russell, Rapid Comm. Mass Spectrom., 1994,8, 26-31.

71) "Aerosol Matrix-Assisted Laser Desorption Ionization for Liquid Chromatography Time-of-Flight Mass Spectrometry" K.K. Murray; T.M. Lewis; M.D. Beeson; D.H. Russell, Anal. Chem., 1994,66, 1601-1609.

72) "Transformation of Polysulfidic Sulfur to Elemental Sulfur in Oxidative Adsorption Processes" E.T. Clarke; T. Solouki; D.H. Russell; A.E. Martell, Anal. Chem. Acta, 1994, 299, 97-111.

73) "Effects of Heavy Atom Substituents on Matrices used for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry" L.M. Preston-Schaffter; G.R. Kinsel, D.H. Russell, J. Am. Soc. Mass. Spectrom., 1994, 5, 800-806.

74) "Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry of Paclitaxel and Related Taxanes", M.E. Gimon; G.R. Kinsel; R.D. Edmondson; D.H. Russell; T.R. Prout; N. Wald, J. Nat. Prod., 1994, 57, 1404-1410.

75) "Laser spray Ionization for Biological Mass Spectrometry", K.K. Murray, D.H. Russell, Am. Lab., 1994, June, 38.

76) "Collisional Relaxation Studies of Meatstable Electronic States of Fe+" V.J.B. Oriedo; T. Solouki,;D.H. Russell, J. Am. Soc. Mass Spectrom., 1995, 6, 543-553.

77) "Photodissociation of High Molecular Weight Peptides and Proteins in a Two-Stage Linear Time of Flight Mass Spectrometer," M. E. Gimon-Kinsel; G. R. Kinsel; R. D. Edmondson; D. H. Russell, J. Am. Soc. Mass Spectrom., 1995, 6, 578-587.

78) "Design and Calibration of an Electrostatic Energy Analyzer-Time-of-Flight Mass Spectrometer for Measurement of Laser-Desorbed Ion Kinetic Energies," G. R. Kinsel; D. H. Russell, J. Am. Soc. Mass Spectrom., 1995, 6, 619-626.

79) "Aerosol Matrix-Assisted Laser Depsorption Ionization: Effect of Analyte Concentration and Matrix-to-Analyte Ratio," M. D. Beeson; K. K. Murray; D. H. Russell, Anal. Chem, 1995, 34, 1981-1986.

80) "Aerosol Matrix-Assisted Laser Desorption Ionization: I. Effect of Solvent on Ion Signal," M. D. Beeson; D. H. Russell, J. Mass Spectrom., 1996, 31, 295-302.

81) "Evaluation of Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Measurement Accuracy by Using Delayed Extraction", R.D. Edmondson; D.H. Russell, J. Am. Soc. Mass Spectrom., 1996, 7, 995-1001

82) "Ion motion in a Fourier transform ion cyclotron resonance wire ion guide cell", K.J. Gillig, B.K. Bluhm, D.H. Russell, Int. J. Mass Spectrom Ion Proc., 1996, 157/158,129-147

83) "Effects of Matrix Structure/Acidity on Ion Formation in Matrix-Assisted Laser Desorption Ionization Mass Specrometry," M.E. Gimon-Kinsel, L.M. Preston-Schaffter; G.R. Kinsel; D.H. Russell, J. Am. Chem. Soc., 1997, 119 , 2534-2540

84) "Profile and Flight Time Analysis of Bovine Insulin clusters as a Probe of MALDI Ion Formation Dynamics," G.R. Kinsel; R.D. Edmondson; D.H. Russell, J. Mass Spectrom., 1997, 32, 714-721.

85) "Evaluation of the Variables that Affect Resolution in Delayed Extraction MALDI TOF," D.C. Barbacci; R.D. Edmondson; D.H. Russell, Int. J. Mass Spectrom. and Ion Proc., 1997, 165-166, 221-235.

86) "Improving Mass Spectrometric Sequencing of Arginine Containing Peptide by Derivatization with Acetylacetone," S. Dickler; J.W. Kelly; D.H. Russell, J. Mass Spectrom., 1997, 32, 1337-1349.

87) "Test of the Potential of a dATP Surrogate for Sequencing via MALDI-MS," S. Jacutin, A. Zhang, D. Russell, R. Gibbs., and K. Burgess, Nucleic Acid Research, 1997, 25, 5072-5076.

88) "Characterization of Proteins Utilized in the Desulfurization of Petroleum Products of Matrix Assist Laser Desorption Ionization Time of Flight Mass Spectrometry", B.K. Wolf, L.W. Sumner, S.J. Shields, K. Nielsen, K.A. Gray, D.H. Rusell, Anal. Biochem., 1998, 260, 117-127.

89) "Photochemistry and Proton Transfer Reaction Chemistry of Selected Cinnaminic Acid Derivatives in Hydrogen Bonded Environments," Y. Huang, D.H. Russell, Int. J. Mass Spectrom. Ion Proc., 1998, 175, 187-204.

90) " Effects of the Water Content in the Sample Preparation for MALDI on the Mass
Spectra", I.D. Figueroa, O. Torres, D.H. Russell, Anal. Chem., 1998, 70, 4527-4533

91) "Multi-anode Detection in Electrospray Ionization Time-of-Flight Mass Spectrometry", D.C. Barbacci, D.H. Russell, J.A. Schultz, J. Holocek, S. Ulrich, W. Burton, M.Van Stipdonk, J. Am. Soc. Mass Spectrometry, 1998, 9, 1328-1333.

92) "A Method for Removal of N-BOC Protecting Groups from Substrates on TFA- sensitive Resins", A.J. Zhang, D.H. Russell, J. Zhu, K. Burgess, Tetrahedron Let., 1998, 39, 7439-7442.

93) "Conformations of Protonated Gas-Phase Ions: Evidence for Intramolecular Hydrogen Bonding," M.E. Gimon-Kinsel, D.C. Barbacci, D.H. Russell, J. Mass Spectrom., 1999, 34, 124-136.


94) "MALDI H/D Exchange Studies to Probe Peptide Conformational Changes", Iddys D. Figueroa and David Russell, JASMS, 1999, 10, 719-731.

95) "Novel Method for [M+Cu]+ Ion Formation by MALDI", S.J. Shields, B.K. Bluhm, D.H. Russell, Int. J. Mass Spectrom. Ion Proc., 1999, 182/183, 185-195.

96) "Investigation of the Dynamics of MALDI Ion Formation Using an Electrostatic Analyzer/Time-of-Flight Mass Spectrometer", G.R. Kinsel, M.E. Kinsel, K.J. Gillig, D.H. Russell, J. Mass Spectrom., 1999, 34, 684-690.

97) "Sequence and Side-Chain Specific Photfragment (193 mm) Ions from Protonated Substance-P by Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry", D. Barbacci and D. H. Russell, J. Mass Spectrom., 1999, 10, 1038-1040.

98) "UV-MALDI MS Characterization of 2,5-Dihydroxybenzoic Acid Induced Reductive Hydrogenation of Oligonucleotides on Cytosine Residues," J.K. Koomen and D.H. Russell, J. Mass Spectrom., 2000, 35, 1025-1034.

99) "Thermal Denaturation: A Useful Technique in Peptide Mass Mapping," Z.Y. Park and D.H. Russell, Anal. Chem., 2000, 72, 2667-2670.

100) "Fragmentation Chemistry of [M+Cu]+ Peptide Ions Containing an N-terminal Arginine," S.J. Shields, B.K. Bluhm, and D.H. Russell, JASMS, 2000, 11, 626-638.

101) "Improvement of Resolution, Mass Accuracy, and Reproducibility in Reflected Mode DE-MALDI-TOF Analysis of DNA using Fast Evaporation-Overlayer Sample Preparations," J.M. Koomen, W.K. Russell, J.M. Hettick, and D. H. Russell, Anal. Chem., 2000, 72, 3860-3866.

102) "Coupling High Pressure MALDI with Ion Mobility/Orthogonal Time-of-Flight Mass Spectrometry," K.J. Gillig, B. Ruotolo, E.G. Stone, D. H. Russell, K. Fuhrer, M. Gonin, and A.J. Schultz, Anal. Chem., 2000, 72, 17, 3965-3971.

103) "Development of a Fourier transform ion cyclotron resonance mass spectrometer - ion mobility spectrometer," B.K. Bluhm, K.J. Gillig, and D.H. Russell, Rev. Scien. Instrum., 2000, 71, 11, 4078-4086.

104) "Separation of Spin-Orbit Coupled Metastable States of Kr+ and Xe+ by Ion Mobility," B.K. Bluhm, S.North, D.H. Russell, J. Chem. Phys., 2001, 114, 5, 1709-1715.

105) "Fine-Tuning the Ring-Size of Metallacyclophanes: A Rational Approach to Molecular Pentagons," C.S. Campos-Fernandez, R. Clerac, J.M. Koomen, D.H. Russell, and K.R. Dunbar, J. Am. Chem. Soc., 2001, 123, 773-774.

106) "Determination of Copper Binding Site in Peptides Containing Basic Residues: A Combined Experimental and Theoretical Study," B.K. Bluhm, S.J. Shields, C.A. Bayse, M.B. Hall, D.H. Russell, Int. J. Mass Spectrom., 2001, 204, 31-46.

107) "Surface-Induced Dissociation (SID) on a MALDI-Ion Mobility-Orthogonal-Time-of-Flight Mass Spectrometer: Sequencing Peptides from an "In-solution" Protein Digest," Earle G. Stone, Kent J. Gillig, Brandon T. Ruotolo, Katrin Fuhrer, Marc Gonin, Albert J. Schultz, and David H. Russell, Anal. Chem., 2001, 73, 2233-2238.

108) "Identification of Individual Proteins in Complex Protein Mixtures by High Resolution, High Mass Accuracy MALDI TOF Mass Spectrometry Analysis of In-Solution Thermal Denaturation/Enzymatic Digestion," Zee-Yong Park and David H. Russell, Anal Chem., 2001, 73, 2558-2564.

109) "Proteolysis in Mixed Organic-Aqueous Solvent Systems: Applications for Peptide Mass Mapping Using Mass Spectrometry," William K. Russell, Zee-Yong Park, and David H Russell, Anal. Chem., 2001, 73, 2682-2685.

110) "Optimization of Sample Preparation for Peptide Sequencing by MALDI-TOF Photofragment Mass Spectrometry," Justin M. Hettick, David L. McCurdy, Damon C. Barbacci, and David H. Russell, Anal. Chem., 2001, 73, 5378-5386
.
111) "Optimization of a matrix-assisted laser desorption ionization-ion mobility-surface-induced dissociation-orthogonal-time-of-flight mass spectrometer: simultaneous acquisition of multiple correlated MS1 and MS2 spectra," Earle G. Stone, Kent J. Gillig, Brandon T. Ruotolo, and David H. Russell, Int. J. Mass Spectrom., 2001, 212, 519-533.

112) "Accurate Mass Measurement of DNA Oligonucleotide Ions Using High-Resolution Time-of-Flight Mass Spectrometry," John K. Koomen, William K. Russell, Shane E. Tichy, and David H. Russell, J. Mass Spectrom., 2002, 37, 357-371.

113) "Observation of Conserved Solution-Phase Secondary Structure in Gas-Phase Tryptic Pepties," Brandon T. Ruotolo, Guido F. Verbeck, Lisa M. Thomson, Kent J. Gillig, and David H.Russell, JACS, 2002,124, 16, 4214-4215.
114) "A Fundamental Introduction to Ion Mobility Mass Spectrometry Applied to the Analysis of Biomolecules," Guido F. Verbeck, Brandon T. Ruotolo, Holly A. Sawyer, Kent J. Gillig, and David H. Russell, J. Biomol. Tech., 2002, 13, 2, 56-61.

115) "Distinguishing between Phosphorylated and Non-phosphorylated Peptides by Ion Mobility-Mass Spectrometry." Brandon T. Ruotolo, Guido F. Verbeck IV, Lisa M. Thompson, Amina S. Woods, Kent J. Gillig, David H. Russell, J. Proteome Research 2002, 1, 303-306.

116) "Analysis of protein mixtures by matrix-assisted laser desorption ionization-ion mobility-orthogonal-time-of-flight mass spectrometry," Brandon T. Ruotolo, Kent J. Gillig, Earle G. Stone, David H. Russell, Katrin Fuhrer, Marc Gonin, J. Albert Schultz, Int J. Mass Spec, 2002, 219, 253-267.

Papers Submitted

"A High Repetition Rate (1kHz) Nanolaser for High Throughput Atmospheric Pressure MALDI-Quadrupole-Time-of-Flight Mass Spectrometry," John A. McLean, William K. Russell, and David H. Russell, Anal Chem, submitted 8/7/02.

"Matrix-assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometric Investigation of Single-Isomer, Trialkylsilyl Ether Derivatives of Cyclodextrins," W.K. Russell, B.P. Wolf, L.W. Sumner, D.H. Russell, L. Bortun, M.B. Busby, H. Cai, A. Kolberg, J. Link, D.K. Maynard, B. J. Vincent, W. Zhu, and G. Vigh, J. Chrom., accepted.

"The Use of an In Situ Infrared Radiation Emitter to Study the Chemistry of the C8H8O2.+ Ion Formed from Methyl Benzoate," S.M. Peterson and D.H. Russell, Euro. J. Mass Spectrom., submitted.

"Development and Characterization of a Heated Wire Ion-guide (WIG) Cell to Study the Dissociation Dynamics of the C7H7Cl.+ Ion Formed from Benzyl Chloride," S.M. Peterman and D.H. Russell, Int. J. Mass Spectrom., submitted.

"Optimization of a MALDI-IM-SID-o-TOF Mass Spectrometer: Simultaneous Acquisition of Multiple Correlated MS1 and MS2 spectra," Int. J. Mass Spectrom., in press.

LBMS Collaborations

1) "MALDI and FAB Mass spectometry of Nucleoside Triphosphates: A Comparative Study," K. Burgess; D.H. Russell; A. Shitangkoon; A.J. Zhang, Nucleo. Nucleo, 1996, 15, 1719-1723

2) "Template Effect for O2 Addition across cis-Sulfur Sites in Nickel Dithiolates," C.A. Grapperhaus; M.Y. Darensbourg; L.W. Sumner; D.H. Russell, J. Am. Chem. Soc., 1996, 118, 1791-1792

3) "Identification of the Naturally Occurring Flavin of Nitroalkane Oxidase from Fusarium Oxysporum as a 5-Nitrobutyl-FAD and Conversion of the Enzyme to the Active FAD-Containing Form," G. Gadda; R.D. Edmondson; D.H. Russell; P.F. Fitzpatrick, J. Biol. Chem., 1997, 272 , 5563-5570

4) "Solid Phase Synthsis of Oligoureas," K. Burgess; J. Ibarzo; D.S. Linthicum; D.H. Russell; H. Shin; A. Shitangkoon; R. Totani; A.J. Zhang, J. Am. Chem. Soc., 1997, 119, 1556-1564.

5) " MALDI-MS as a Monitor of the Purification and Folding of Synthetic Eclosion Hormone", Y.J. Wang, L. Urttas, B.E. Dale, D.H. Russell, G. Kinsel, L.M Preston-Schaffter, V. Johnson, T.K. Hayse, Peptides, 1997, 18, 337-346.

6) "Identification of Native Flavin Adducts from Fusarium Oxysporum Using Accurate MALDI-TOF-MS," R.D. Edmondson; G. Gadda; P.F. Fitzpatrick; D.H. Russell, Anal. Chem., 1997, 62, 2862-2865.

7) "Photolytic Mass Laddering for Fast Characterization of Oligomers on Single Resin Beads," K. Burgess; C.I. Martinez; D.H. Russell; H. Shin; A.J. Zhang, J. Org. Chem., 1997, 62, 5662-5663.

8) "Structure and Function of Normal and Transformed Murine Acyl-CoA Binding Proteins," R. Gossett; R.D. Edmondson; C.A. Jolly; T.H. Cho; D.H. Russell; J. Knudsen; A. Keir; F. Schroeder, J. Biol. Chem., 1998, 350, 201-203.

9) "Isolation and Characterization of 26 - and 30-kDa Rat Liver Proteins
Immunoreactive to Anti-Sterol Carrier Protein-2 Antibodies," L. Pu, W.B. Foxworth, A.B. Kier, R.S. Annan, S.A. Carr, R. Edmondson, D.H. Russell, W.G. Wood, F. Schroeder. Protein Expression and Purification, 13, 337-348, 1998.

10) "Electrochemical Aspects of Electrospray Ionization Mass Spectrometry of Biomimetic Metallodithiolates", L.W. Sumner; B.P. Wolf; D.H. Russell; C.A. Grapperhaus; G. Musie; M.Y. Darensbourg, Anal. Chem., submitted.

11) "Isolation and characterization of two distinct forms of liver fatty acid
binding protein from rat", E.J. Murphy; R.D. Edmondson; D.H. Russell; S. Colles;
F. Schroeder, Biochimica et Biophysica Acta, 1999,1436, 413-425.

12) " Fast C18 Solid Phase Desalting/Delipidation of the Human Serum Apolipoproteins for MALDI and ESI analysis," L.K. Watkins, P.V. Bondarenko, D.C. Barbacci, S.Song, S.L. Cockrill, D.H. Russell, and R.D. Macfarlane, J.Chrom., 1999, 840, 183-193.

13) "The Structure of an Insect Chymotrypsin," I. Botos, E. Meyer, M. Nguyen, S. M. Swanson, J.M. Koomen, D.H. Russell, and E.F. Meyer, J. Mol. Biol., 2000, 298, 895-901.

14) "Pro-sterol Carrier Protein-2: Role of the N-terminal Presequence in Structure, Function, and Peroxisomal Targeting," F. Schroeder, A. Frolov, O. Starodub, B.B. Atshaves, W. Russell, A. Petrescu, H. Huang, A.M. Gallegos, A. McIntosh, D. Tahotna, D.H. Russell, J.T. Billheimer, C.L. Baum, and A.B. Kier, J. Bio. Chem., 2000, 275, 33, 25,547-25,555.

15) "Characterization of Poly(amidoamine) Dendrimers and their Complexes with CU2+ by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry," Li Zhou, David H. Russell, Mingqi Zhao, and Richard M. Crooks, Macro, 2001, 34, 3567-2573.

16) "Artifcat-free Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectra of tert.-butyldimethylsilyl Ether Derivatives of Cyclodextrins used for the Synthesis of Single-Isomer, Chiral Resolving Agents for Capillary Electrophoresis," W.K. Russell, D.H. Russell, M.B. Busby, A. Kolberg, S. Li, D.K. Maynard, S. Sanchez-Vindas, W. Zhu, and Gy. Vigh, J. Chrom., 2001, 914, 325-330.

17) "Pulsed-Alkylation Mass Spectrometry for the Study of Protein Folding and Dynamics: Application to the Study of the Folding and Assembly of Bacterial Luciferase," Julius L. Apuy, Zee-Yong Park, Paul D. Swartz, Lawrence J. Dangott, David H. Russell, and Thomas O. Baldwin, Biochem., 2001, 40, 15153-15163.

18) "Ratiometric Pulsed Alkylation/Mass Spectrometry of the Cysteine Pairs in Individual Zinc Fingers of MRE-Binding Transcription Factor-1 (MTF-1) as a Probe of Zinc Chelate Stability," Julius L. Apuy, Xiaohua Chen, David H. Russell, Thomas O. Baldwin, and David P. Giedroc," Bio Chem, 2001, 40, 15164-15175.

19) "A Study of Peptide-Peptide Interactions Using MALDI Ion Mobility o-TOF and ESI Mass Spectrometry," Amina S. Woods, John M. Koomen, Brandon T. Ruotolo, Kent J. Gillig, and David H. Russell, and Katrin Fuhrer, Marc Gonin, Thomas F. Egan, and J. Albert Schultz, J Am Soc Mass Spec, 2002, 13, 166-169.

20) "Oligonucleotide Analysis with MALDI-Ion Mobility-TOFMS," John K. Koomen, Brandon T. Ruotolo, Kent J. Gillig, John M. McLean, and David H. Russell, and Mijeong Kang and Kim R. Dunbar, and Katrin Fuhrer, Marc Gonin, and J. Albert Schultz, Fresenius J Anal. Chem., 2002, submitted.

21) "Membrane Charge and Curvature Determine Interaction with Acyl-CoA Binding Protein (ACBP) and Fatty Acyl-CoA Targeting," Hsu Chao, Gregory G. Martin, William K. Russell, Suryakant D. Waghela, David H. Russell, Friedhelm Schroeder, and Ann B. Kier, Biochem, 2002, in press.

22) "Occurrence of Insect Kinins in the Flesh Fly, Stable Fly and Horn Fly - Mass Spectrometric Identification from Single Nerves and Diuretic Activity," Ronald J. Nachman, Geoffrey M. Coast, Shane E. Tichy, David H. Russell, J. Allen Miller, and Reinhard Predel, 2002, submitted (to ???).

Review Articles and/or Book Chapters

1) "Gas Phase Polar Cycloaddition Reactions," D. H. Russell and M. L. Gross, in "Lecture Notes in Chemistry, Ion Cyclotron Resonance Spectrometry," Series 7, H. Hartmann and K. P. Wanczek, (Eds.), Springer-Verlag, Berlin, 1978.

2) "Mixture Analysis by High Resolution Mass Spectrometry/Mass Spectrometry," D. H. Russell, E. H. McBay, and T. R. Mueller, Amer. Lab., 12, 50, 1980.

3) " Mass Spectrometry," (a biennial review) A. L. Burlingame, A. Delle, and D. H. Russell, Anal. Chem., 54, 363R, 1982.

4) "Triple Sector Instruments for High Resolution MS/MS," in "Tandem Mass Spectrometry," F. W. McLafferty (Ed.), Wiley Interscience, New York, 1983.

5) " Mass Spectrometry," (a biennial review) A. L. Burlingame, J. O. Whitney, and D. H. Russell, Anal. Chem., 56, 417R, 1984.

6) "Desorption Ionization and Fourier Transform Mass Spectrometry for the Analysis of Large Biomolecules," D. H. Russell and M. E. Castro, in "Ion Formation from Organic Solids," A. Benninghoven (ed.), Springer Series in Chemical Physics, 9, Springer-Verlag, Berlin, p. 209, 1986.

7) "Some Aspects of the Chemistry of Ionic Organo-Alkali Metal Halides Clusters Formed by Desorption Ionization," L.M. Mallis; M.E. Castro; D.H. Russell, in A. Bennninghoven (Ed.), "Secondary Ion Mass Spectrometry--SIMS-V", Springer Series in Chemical Physics, 44, Springer-Verlag, Berlin, p. 506, 1986.

8) "Fourier Transform Mass Spectrometry for High Mass Applications," M.E. Castro; L.M. Mallis; D.H. Russell in A. Benninghoven (Ed.), "Secondary Ion Mass Spectrometry--SIMS-V", 44, Springer-Verlag, Berlin, p. 488, 1986.

9) "Cs+ Ion Desorption Ionization Fourier Transform Mass Spectrometry (DI-FTMS) of Large Molecules," M. E. Castro and D. H. Russell, in Advances in Mass Spectrometry 1985 Part B, J. F. J. Todd (Ed.), John Wiley and Sons, 1986.

10) "Laser-Ion Beam Photodissociation Studies of Chromophores Related to 1,3-Butadiene," D. H. Russell, R. E. Tecklenburg, L. Sellers-Hann, and R. E. Krailler, in Advances in Mass Spectrometry 1985 Part B, J. F. J. Todd (Ed.), John Wiley and Sons, 1986.

11) "The Synthesis and Reactivity of Transition Metal Cluster Fragments in the Gas Phase," D. H. Russell, D. A. Fredeen, and R. E. Tecklenburg, in Advances in Mass Spectrometry 1985 Part B, J. F. J. Todd (Ed.), John Wiley and Sons, 1986.

12) "Tandem Mass Spectrometry Studies of Large Molecules Ionized by Fast-Atom Bombardment (FAB)," D. L. Bricker and D. H. Russell, in Advances in Mass Spectrometry 1985 Part B, J. F. J. Todd (Ed.) John Wiley and Sons, 1986.

13) "High Mass Fourier Transform Mass Spectrometry: Present Capabilities and Future Potential," D.H. Russell and M. E. Castro, in "Mass Spectrometry in Biomedical Research," S. J. Gaskell (Ed.), J. Wiley and Sons, Inc. New York, 1986, 313-338.

14) "An Evaluation of Fourier Transform Mass Spectrometry for High Mass Applications," D. H. Russell, Mass Spectrometry Reviews, 5, 167, 1986.

15) "Mass Spectrometry of Biomolecules," D. H. Russell, in "The Importance of Chemical "Speciation" in Environmental Processes," M. Bernhard, F. E. Brinckman, and P. J. Sadler (Eds.), Dahlem Konferenzen, 1986, Springer-Verlag, Berlin, pp. 631-641.

16) "Detection of High Mass (>m/z 5,000) Ions by Fourier Transform Mass Spectrometry", C.D. Hanson, M.E. Castro, D.H. Russell, D.F. Hunt, J. Shabanowitz in Fourier Transform Mass Spectrometry, Evolution, Innovation, and Applications, M. Buchanan (Ed.), ACS Symposium Series 359, 1987.

17) "Inorganic Chemistry in the Gas Phase," Modern Inorganic Chemistry, J. P. Fackler Series Editor, D. H. Russell Vol. Editor, Plenum Press, 1989.

18) "Fundamental Reviews on Mass Spectrometry," A. L. Burlingame and D. H. Russell, Anal. Chem. 1988, 60, 294R.

19) "An evaluation of the analytical utility of the photodissociation of fast ion beams", R.E. Tecklenburg and D.H. Russell, Mass Spectrom. Rev, 1990, 9, 405-451

20) "Recent Developments in Experimental FT-ICR," C. D. Hanson, E. L. Kerley, and D. H. Russell, Treatise on Analytical Chemistry, Part I, Vol. 11, 2nd Edition, J. D. Winefordner (Ed), J. Wiley, A. Kerley and David H. Russell, Int. J. Mass Spectrom Ion Processes, 1991, 110, 215.

21) "Fundamental Review, and Mass Spectrometry," A. L. Burlingame, T. Baille, D. H. Russell, Anal. Chem., 1992, 64, 467R-502R.

22) "Tandem Time-of-Flight Mass Spectrometry - A Magnetic Sector-Reflectron Time-of-Flight Mass Spectrometer", in Time-of-Flight Mass Spectrometry, R.J. Cotter (Ed.) ACS Symposium Series 549, 1993.

23) "Development of a Fourier-Transform Ion Cyclotron Resonance (FTICR) Mass Spectrometry Method for Studies of Metal Ion Excited States," D.H. Russell; J.V.B. Oriedo; T. Solouki, B. S. Freiser (Ed.) Organometallic Ion Chemistry, 1996, 197-228

24) "High Resolution Mass Spectrometry: A Tutorial," D.H. Russell; R.D. Edmondson, J. Mass Spectrom. 1997, 32, 263-276

25) "Mass Spectrometry for Chemists and Biochemists, Second Edition", D. H. Russell, R.A.W. Johnstone, M.E. Rose (Eds.) JASMS, 1998, 9, 6, 649-650.

26) "Time-of-Flight Mass Spectrometry: Instrumentation and Applications in Biological Research," D.H. Russell, JASMS, 1998, 9, 1104-1105.

27) "Identification of Proteins from Whole Cell Lysates: High Resolution TOF MS," D.H. Russell and Z.Y. Park, Proceedsing of SPIE, 2000, 3926, 48-52.

28) "Protein Mixture Analysis by MALDI/mobility/time-of-flight mass spectrometry," D.H. Russell, K.J. Gillig, E. Stone, Z.Y. Park, K. Fuhrer, M. Gonin, A.J. Schultz, Proceedings of SPIE, 2000, 3926, 69-78.

ICR Newsletter Contributions

1) "Effects of Magnetic Inhomogeneities on Partitioning in the Two-Section Cell", E.L. Kerley, C.D. Hanson, D.H. Russell.

2) "Photodissociation of Complex Biomolecules Ionized by Matrix-assisted Laser Desorption in FTICR Experiments", T. Solouki, V.J. Oriedo, F.H. Strobel, D.H. Russell.

3) "Probing Ion Reactivity in the Presence of an In Situ Infrared Radiative Emmiter", S.M. Peterman, D.H. Russell.

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