Sczepanski Research Group

Department of Chemistry

Dr. Yu Zeng

Research Scientist
Office: 2520 Chemistry


Dr. Zeng received her M.S. in biochemistry from Sichuan University in China with Professor Mingshan Liang in 1996; and Ph.D. in botany with Professor Fang Chen from Sichuan University in 2003, then started her Assistant and Associate Professor career in Sichuan University. In 2005, she was awarded Government Scholarship of Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) and conducted postdoctoral research in Institute of Molecular and Cellular Biosciences, the University of Tokyo with Professor Kan Tanaka. From 2007, she conducted postdoctoral research in Ohio University with Prof. Shawn Chen, where she developed a highly efficient strategy for identifying and cloning biosynthetic gene clusters of Trojan horse antibiotic albomycin produced by Streptomyces, and a method of enzymatically and two-step chromatography purification of SerRS inhibitor. In 2011, Dr. Zeng joined Professor Wenshe Liu at Texas A&M University as a postdoctoral research associate, successfully evolved PylRS mutants that are selective for an enzymatically cleavable NCAA and applied this technique to the recombinant synthesis of histones and P53 with Kme1, Kme2, and evolved PylRS mutant for multiple lysine derivatives incorporation, and reassigned rare AGG codon and four-base codons to code multiple NCAA in the areas of expanding the genetic code. In 2015, Dr. Zeng joined Professor Sczepanski at Texas A&M University as an assistant research scientist and focus on the In vitro selection of ligand specific cross-chiral DNAzymes and application in intracellular sensing of structured RNAs, and poly(ADP-ribose) polymerase and its role in DNA repair.