Sczepanski Research Group

Department of Chemistry

Publications

  1. Kabza, A. M., Sczepanski, J. T.* An L-RNA Aptamer with Expanded Chemical Functionality Inhibits MicroRNA Biogenesis. ChemBioChem 18, 1824-1827 (2017).
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Before A&M

  1. Sczepanski, J. T., Joyce, G. F. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. J. Am. Chem. Soc. 137, 16032–16037 (2015).
  2. Sczepanski, J. T., Joyce, G. F. A Cross-Chiral RNA Polymerase Ribozyme. Nature 515, 440–442 (2014). This article was highlighted in Nature News & Views (Nature 515, 347–348 [2014]) and C&E News (Chem. Eng. News 92, 39 [2014]).
  3. Sczepanski, J. T., Joyce, G. F. Binding of a Structured D-RNA Molecule by an L-RNA Aptamer. J. Am. Chem. Soc. 135, 13290–13293 (2013).
  4. Zhou, C.; Sczepanski, J. T., Greenberg, M. M. Histone Modification via Rapid Cleavage of C4'-Oxidized Abasic Sites in Nucleosome Core Particles. J. Am. Chem. Soc. 135, 5274–5277 (2013).
  5. Sczepanski, J. T., Zhou, C., Greenberg, M. M. Nucleosome Core Particle-Catalyzed Strand Scission at Abasic Sites. Biochemistry 52, 2157–2164 (2012).
  6. Sczepanski, J. T., Joyce, G. F. Synthetic Evolving Systems that Implement a User-Specified Genetic Code of Arbitrary Design. Chem. Biol. 19, 1324–1332 (2012).
  7. Zhou, C.; Sczepanski, J. T., Greenberg, M. M. Mechanistic Studies on Histone Catalyzed Cleavage of Apyrimidinic/Apurinic Sites in Nucleosome Core Particles. J. Am. Chem. Soc. 134, 16734–16741 (2012).
  8. Sczepanski, J. T., Hiemstra, C. N., Greenberg, M. M. Probing DNA Interstrand Cross-Link Formation by an Oxidized Abasic Site Using Nonnative Nucleotides. Bioorg. Med. Chem. 19, 5788–5793 (2011).
  9. Sczepanski, J. T., Wong, R. S., McKnight, J. N., Bowman, G. D., Greenberg, M. M. Rapid DNA-Protein Cross-Linking and Strand Scission by an Abasic Site in a Nucleosome Core Particle. Proc. Natl. Acad. Sci. USA. 107, 22475–22480 (2010).
  10. Wong, R. S., Sczepanski, J. T., Greenberg, M. M. Excision of a Lyase-Resistant Oxidized Abasic Lesion from DNA. Chem. Res. Toxicol. 23, 766–770 (2010).
  11. Greenberg, M. M., Newman, C. A., Resendiz, M., Sczepanski, J. T. Photochemical Generation and Reactivity of 5,6-Dihydrouridin-6-yl Radical. J. Org. Chem. 74, 7007–7012 (2009).
  12. Sczepanski, J. T., Jacobs, A., Van Houten, B., Greenberg, M. M. Double-Strand Break Formation During Nucleotide Excision Repair of a DNA Interstrand Cross-Link. Biochemistry 48, 7565–7567 (2009). This article was highlighted in Chemical Research in Toxicology (Chem. Res. Toxicol. 22, 1651 [2009]).
  13. Sczepanski, J. T., Jacobs, A., Majumdar, A., Greenberg, M. M. Scope and Mechanism of Interstrand Cross-Link Formation by the C4'-Oxidized Abasic Site. J. Am. Chem. Soc. 131, 11132–11139 (2009).
  14. Sczepanski, J. T., Jacobs, A., Greenberg, M. M. Self-Catalyzed DNA Interstrand Cross-Link Formation by an Abasic Site. J. Am. Chem. Soc. 130, 9646–9647 (2008). This article was highlighted in Chemical Research in Toxicology (Chem. Res. Toxicol. 21,1650 [2008]) and chosen for JACS Select collection focused on nucleic acids (Vol. 4).