Peer Reviewed Publications

2002~2005   2007   2008   2010   2011  2012  2013  2014  2015  2016   2017

 

 

2017

  • Zhipeng A. Wang and Wenshe R. Liu*. "Proteins with Site-Specific Lysine Methylation", Chem. Eur. J., 10.1002/chem.201701655. ARTICLE LINK

Chem Eur J-10.1002

 

  • Mingzhao Zhu, Wayne D. Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G. Hull, Sung Wook Chok, Robyn D. Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T. Wilson, Ju Anne Yau, James T. Moore, Caitlen B. Walker, James C. Sacchettini, Wenshe R. Liu, Stephan A. Sieber, Jeffrey W. Smith and Daniel Romo*. "A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-orlistat Hybrids", Bioorg. Med. Chem., 2017, 25, 2901-2916. ARTICLE LINK

  • Bioorg Med Chem 2017

  • Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu and Qing Lin*, and Wenshe R. Liu*. "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking", J. Am. Chem. Soc., 2017, 139, 6078-6081. ARTICLE LINK

  • jacs_2017_139_6078

     

  • Zhipeng A. Wang, Yadagir Kurra, Xin Wang, Yu Zeng, Yan-Jiun Lee, Vangmayee Sharma, Hening Lin, Susie Y. Dai*, and Wenshe R. Liu*. "A Versatile Approach for Site-Specific Lysine Acylation in Proteins", Angew. Chem. Int. Ed., 2017, 56, 1643-1647. ARTICLE LINK

  • Angew chem Int Ed_2017_56_1643

     

  • Zhipeng A. Wang, Yu Zeng, Yadagir Kurra, Xin Wang, Jeffrey M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu*. "A Genetically Encoded Allysine for the Synthesis of Proteins with Site-specific Lysine Dimethylation", Angew. Chem. Int. Ed., 2017, 56, 212-216. ARTICLE LINK

Angew_2017_56_212

 

 

 

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2016

  • Vangmayee Sharma, Yane-Shih Wang, and Wenshe R. Liu, "Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics”, ACS Chem Biol. 2016, 11, 3305-3309. ARTICLE LINK

ACS Chem Biol 2016_11_3305

 

  • Yan-Jiun Lee, M. J. Schmidt, Jeffery M. Tharp, Annemarie Weber, Amber L. Koenig, Hong Zheng, Jianmin Gao, Marcey L. Waters, Daniel Summerer,* and Wenshe R. Liu* "Genetically Encoded Fluorophenylalanines Enable Insights into the Recognition of Lysine Trimethylation by an Epigenetic Reader" Chem. Commun., 2016, 52, 12606-12609.ARTICLE LINK

Chem_Commun_2016_52_12606

 

  • Wang, Wesley Wei; Zeng, Yu; Wu, Bo; Deiters, Alexander and Liu, Wenshe*, "A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes", ACS Chem. Biol., 2016, 11, 1973-1981. ARTICLE LINK

cb_2016_11_1973

 

  • Hsu, Willie W.; Wu, Bo and Liu, Wenshe R.*, "Sirtuins 1 and 2 Are Universal Histone Deacetylases", ACS Chem. Biol., 2016, 11, 792-799. ARTICLE LINK

bc_2016_11_792

 

  • Tharp, Jeffery M. and Liu, Wenshe R.*, "The 'π-Clamp' Offers a Novel Strategy for Site-selective Protein Modification", ChemBioChem, 2016, 17, 883-885. ARTICLE LINK

bcb_2016_17_883

 

  • Lee, Yan-Jiun; Kurra, Yadagiri and Liu, Wenshe R.*, "Phospha-Michael Addition as a New Click Reaction for Protein Functionalization", ChemBioChem, 2016, 17, 456-461. ARTICLE LINK

cbc_2016_17_456

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2015

  • He, Tao; Gershenson, Anne; Eyles, Stephen J.; Lee, Yan-Jiun; Liu, Wenshe R.; Wang, Jiangyun; Gao, Jianmin; and Roberts, Mary F.*, "Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membran Insertion", J. Biol. Chem, 2015, 290, 19334-19342. ARTICLE LINK
  • Bindman, Noah A; Boeica, Silvia C.; Liu, Wenshe R.; van der Donk, Wilfred A.*, "Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid", J. Am. Chem. Soc., 2015, 137, 6975-6978. ARTICLE LINK

jacs_2015_6975

 

  • Xin, X; Liu, W. R; Sun, L.*, "Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification", Mol. Med. Rep., 2015, 11, 3774-3779. ARTICLE LINK
  • Guan, Dongli; Kurra, Y; Liu, W. R.; Chen, Zhilei*, "A click chemistry approach to site-specific immobilization of a small laccase enables efficient direct electron transfer in a biocathode", Chem. Commun., 2015, 51, 2522-2525. ARTICLE LINK

Chem_Comm_2015_51-2522

 

  • Piscotta, Frank J.; Tharp, Jeffery M.; Liu, W. R.; Link, A. James*, "Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids", Chem. Commun., 2015, 51, 409-412. ARTICLE LINK

Chem_Comm_2015_409

 

 

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2014

  • Wang, Xiaoyan Aria; Kurra, Y; Huang, Y; Lee, Y-J; Liu, W. R.*, E1-Catalyzed Ubiquitin C-Terminal Amidation for the Facile Synthesis of Deubiquitinase Substrates", ChemBioChem, 2014, 15, 37-41. ARTICLE LINK

cbc_2014_15_37

 

  • Lee, Y.-J; Kurra, Y; Yang, Y; Torres-Kolbus, J; Deiters, A; Liu, W. R.*, 'Correction:"Genetically Encoded Unstrained Olefins for Live Cell Labeling with Tetrazine Dyes"', Chem. Commun., 2014, 50, 13396-133968. ARTICLE LINK
  • Lee, Y.-J; Kurra, Y; Yang, Y; Torres-Kolbus, J; Deiters, A; Liu, W. R.*, "Genetically Encoded Unstrained Olefins for Live Cell Labeling with Tetrazine Dyes", Chem. Commun., 2014, 50, 13085-13088. ARTICLE LINK

chem_comm_2014_50-13085

 

  • Kurra, Y; Odoi, K. A; Lee, Y.-J; Yang, Y; Lu, T; Wheeler, S. E; Torres-Kolbus, J; Deiters, A; Liu, W. R.*, "Two Rapid Catalyst-Free Click Reactions for In Vivo Protein Labeling of Genetically Encoded Strained Alkene/Aldyne Functionalities", Bioconjugate Chemistry, 2014, 25, 1730-1738. ARTICLE LINK

acs_bc_2014_25_1730

 

  • Zeng, Yu; Wang, W; Liu, W. R.*, "Towards Reassigning the Rare AGG Codon in Escherichia Coli", ChemBioChem, 2014, 15, 1750-1754. ARTICLE LINK
  • bcb_2014-15_1750

  • Liu, W. R., "Reports from the Chemical Biology of Texas Symposium at the 69th Southwest Regional Meeting of the American Chemical Society", ACS Chemical Biology, 2014, 9, 319-322. ARTICLE LINK
  • Wang, Xiaoshan Shayna; Lee, Yan-Jiun; Liu, W. R*, "The nitrilimine-alkene cycloaddition is an ultra rapid click reaction", Chem. Commum., 2014, 50, 3176-3179. ARTICLE LINK

Chem_Comm_2014_50_3176

 

  • Tuley, A., Lee, Y.-J., Wu, Bo., Wang, Z. U. & Liu, W.R.*, "A genetically encoded aldehyde for rapid protein labelling",, J. Roayl Soc. of Chem. Chem. Commun. 2014, 50, 7424-7426. ARTICLE LINK

Chem_Comm_2014_50_7424

 

  • Tuley, A., Wang, Y.-S., Fang, X., Kurra, Y., Rezenom, Y. H. & Liu, W.R.*, "The genetic incororation of thirteen novel non-canonical amino acids", Chem. Commun., 2014, 50, 2673-2675. ARTICLE LINK

Chem_Comm_2014_50_2673

 

  • Tharp, J. M., Wang, Y.-S., Lee, Y.-J., Yang, Y. & Liu, W.R.*, "Genetic Incorporation of Seven ortho-Substituted Phenylalanine Derivatives", ACS Chem. Biol., 2014, 9 (4), 884-890. ARTICLE LINK

cb_2014_9_884

 

  • Wan, W., Tharp, J. M., & Liu, W.R., “Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool”, Biochemica et Biophysica Acta 2014, 1844, 1059-
  • Liu, W.R.*, "Reports from the Chemical Biology of Texas symposium at the 69th Southwest Regional Meeting of the American Chemical Society", ACS Chem. Biol. 2014, 9, 319-322. ARTICLE LINK

 

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2013

  • Hladilková, Jana, Heyda, J., Rembert, K. B., Okur, H. I., Kurra, Y., Okur, H. I., Liu, W. R., Hilty, C., Cremer, P. S., Jungwirth, P.*, “Effects of End-Group Termination on Salting-Out Constants for Triglycine”, J. Phys. Chem. Lett. 2013, 4, 4069-4073. ARTICLE LINK

JPCL_2013_4_4069

 

  • Paterová, Jana, Rembert, K. B., Heyda, J. Kurra, Y., Okur, H. I., Liu, W. R., Hilty, C., Cremer, P. S., Jungwirth, P.*, “Reversal of the Hofmeister Series: Specific Ion Effects on Peptides”, J. Phys. Chem. B, 2013, 117, 8150-8158. ARTICLE LINK

JPCB_2013_117_8150

 

  • Lee, Y.-J. C., Wu, Bo., Raymond, J. E., Zeng, Y., Fang, X., Wooley, K. L., & Liu, W.R.*, “A Genetically Encoded Acrylamide Functionality”, ACS Chem. Biol., 2013, 8, 1664-1670. ARTICLE LINK

cb_2013_8_1664

 

  • Wang, Y.-S., Fang, X., Chen, H.-Y., Wu, B., Wang, Z.U., Hilty, C.B., & Liu, W.R.*, “Genetically Encoding Twelve meta-Substituted Phenylalanine Derivatives with Diverse Bioorthogonal Functionalities Using a Single Pyrrolysyl-tRNA Synthetase Mutant”, ACS Chem. Biol., 2013, 8, 405-415. ARTICLE LINK

cb_2013_8_405

 

  • Odoi, K.A., Huang Y., Rezenom, Y.H. & Liu, W.R.*, "Nonsense and Sense Cuppression Abilities of Original and Derivative Methanosarcina mazei Pyrrolysyl-tRNA Synthetase-tRNAPyl Pairs in the Escherichia coli BL21 (DE3) Cell Strain", PLOS One, 2013, 8, 357035. ARTICLE LINK

 

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2012

  • O’Donoghue, P, Prat, L., Heinemann, I., Ling, J., Odoi, K.A., Liu, W.R.* & Soll, D.*, “Near-cognate Suppression of Amber, Opal, and Quadruplet Codons Compete with Aminoacyl-tRNAPyl for Genetic Code Expansion”, FEBS Lett., 2012, 21, 393103937. (*co-corresponding authors). ARTICLE LINK
  • Wan, W, Wang, Y.-S., & Liu, W.R.*, “Genetically Encoding Bioorthogonal Functional Groups for Siteselective Protein Labeling”, Organic Chem. Curr. Res., 2012, 1:e111, DOI: 10.4172/2161-0401.1000e111. ARTICLE LINK
  • Wang, Z.U., Wang, Y.-S., Pai, P.-J., Russell, W.K., Russell, D.H. & Liu, W.R.*, “A Facile Method to Synthesize Histones with Posttranslational Modification Mimics”, Biochemistry, 2012, 51:5232-5234. ARTICLE LINK

acs_bc_2012_51_5232

 

  • Wang, Y.-S., Fang, X., Wallace, A.L., Wu, B. & Liu, W.R.*, “A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant Has a Broad Substrate Specificity”, J. Am. Chem. Soc., 2012, 134: 2950-2953.ARTICLE LINK

jacs_2012_134_2950

 

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2011

  • Weinert, B.T., Wagner, S.A., Horn, H., Henriksen, P., Liu, W.R., Olsen, J.V., Jensen, L.J. & Choudhary, C.*, “Proteome-wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation”, Sci. Signal, 2011, 4: ra48.ARTICLE LINK
  • Wang, Y.-S., Russell, W.K., Wang, Z., Wan, W., Dodd L.E., Pai, P.-J., Russell, D.H., & Liu W.R.*, “The De Novo Engineering of Pyrrolysyl-tRNA Synthetase for Genetic Incorporation of L-phenylalanine and Its Derivatives”, Mol. BioSyst., 2011, 7: 714-717. ARTICLE LINK

mbs_2011_7_714

 

  • Liu, W.R.*, Wang, Y.-S. & Wan, W., “Synthesis of Proteins with Defined Posttranslational Modifications Using the Genetic Noncanonical Amino Acid Incorporation Approach”, Mol. BioSyst., 2011, 7: 38-47.ARTICLE LINK

mbs_2011_7_38

 

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2010

  • Wang, Y.-H., Wu, B., Wang, Z., Huang, Y., Wan, W., Russell, W.K., Pai, P.-J., Russell, D.H. & Liu, W.R.*, “A Genetically Encoded Photocaged Nε-methyl-L-lysine” Mol. Biosyst., 2010, 6: 1557-1560. This was an invited submission and featured on Molecular BioSystems 2010 Emerging Investigators Issue. ARTICLE LINK

mbs_2010_6_1557

 

  • Wan, W., Huang, Y., Wang, Z., Russell, W.K., Pai, P.-J., Russell, D.H. & Liu, W.R.*, “A Facile System for Genetic Incorporation of Two Different Noncanonical Amino Acids into One Protein in Escherichia coli”, Angew. Chem. Int. Ed., 2010, 49: 3211-3214. Chosen as a “Hot Paper” by the Editors for its importance in a rapidly evolving field of high current interest and announced in the journal’s press release.ARTICLE LINK

angew_2010_49_3211

 

  • Huang, Y., Russell, W.K., Wan, W., Pai, P.-J., Russell, D.H. & Liu, W.*, “A convenient Method for Genetic Incorporation of Multiple Noncanonical Amino Acids into One Protein in Escherichia coli”. Mol. BioSyst. 2010, 6: 683-686. ARTICLE LINK

mbs_2010_6_683

 

  • Huang, Y., Wan, W., Russell, W.K., Pai, P.-J., Wang, Z., Russell, D.H. & Liu, W.*, “Genetic Incorporation of An Aliphatic Keto-containing Amino Acid into Proteins for Their Site-specific Modificaiton”. Bioorg. Med. Chem. Lett. 2010, 20: 878-880. ARTICLE LINK

Bioorg.Med.Chem.lett_2010_878

 

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2008

  • Brustad, E., Bushey, M.L., Lee, J.W., Groff, D., Liu W. & Schultz, P.G.* “A Genetically Encoded Boronate Containing Amino Acid” Angew. Chem. Int. Ed. Engl., 2008, 47: 8220-8223. ARTICLE LINK
  • Graziano, J.J., Liu, W., Perera, R., Geierstanger, B.H., Lesley, S.A., & Schultz, P.G. “Selecting Folded Proteins from a Library of Secondary Structural Elements”, J. Am. Chem. Soc., 2008, 130: 176-185 ARTICLE LINK

 

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2007

  • Tippmann, E.M.­­­+, Liu, W.+, Summerer, D., Geierstanger, B., Mack, A.V., & Schultz, P.G.*, “A Genetic Encoded Diazirine Photocrosslinker in Escherichia coli”, ChemBioChem, 2007, 8: 2210-2214 (+equally contributing authors) ARTICLE LINK
  • Liu, C.C., Braustad, E., Liu, W.* & Schultz, P.G.*, “Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed with Thrombin”, J. Am. Chem. Soc., 2007, 129: 10648-10649 (*corresponding authors in this paper)ARTICLE LINK
  • Liu, W., Brock, A., Chen, S., Chen, S. & Schultz, P.G.*, “The Genetic Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells”, Nat. Methods. 2007, 4: 239-44. ARTICLE LINK
  • Xie, J., Liu, W., & Schultz, P.G.* “A Genetic Encoded Bidentate, Metal Ion Binding Amino Acid”,Biochem Angew. Chem. Int. Ed., 2007, 46: 9239-9242. ARTICLE LINK
  • Liu, W., Alfonta, L., Mack, A.V. & Schultz, P.G.* “Structural Basis for the Recognition of p-Benzoyl-L-phenylalanyl by Evolved Aminoacyl-tRNA Synthetases”, Angew. Chem. Int. Ed., 2007, 46: 6073-6075. ARTICLE LINK

 

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2002~2005

  • Liu, W., Peterson, P.E., Langston, J.A., Jin, X., Zhou, X., Fisher, A.J. & Toney, M.D.* “Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coli g-Aminobutyrate Aminotransferase”, Biochemistry 2005, 44: 2982-92.ARTICLE LINK
  • 2005_44_2982

 

  • Fogle, E.J., Liu, W., Keller, J. & Toney, M.D.* “Role of Q52 in the Decarboxylation and Transamination of Dialkylglycine Decarboxylase”, Biochemistry 2005, 44: 16392-404.ARTICLE LINK
  • Liu, W., Peterson, P.E., Carter, R.J., Zhou, X., Langston, J.A., Fisher, A.J. & Toney, M.D. “Crystal Structures of Unbound and Aminooxyacetate-bound Escherichia coli g‑Aminobutyrate Aminotransferase. Biochemistry 2004, 43: 10896-905. ARTICLE LINK
  • Liu, W. & Toney, M.D. “Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase”, Biochemistry 2004, 43: 4998-5010.ARTICLE LINK
  • Liu, W., Rogers, C.J., Fisher, A.J. & Toney, M.D. “Aminophosphonate inhibitors of dialkylglycine decarboxylase: Structural basis for slow binding inhibition”, Biochemistry 2002, 41: 12320-28. ARTICLE LINK

 

 

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