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Peer Reviewed Publications

As an independent principle investigator

 

  • Lee, Y.-J. C., Wu, Bo., Raymond, J. E., Zeng, Y., Fang, X., Wooley, K. L., & Liu, W.R.*, “A Genetically Encoded Acrylamide Functionality”, ACS Chem. Biol., in press.
  • Wang, Y.-S., Fang, X., Chen, H.-Y., Wu, B., Wang, Z.U., Hilty, C.B., & Liu, W.R.*, “Genetically Encoding Twelve meta-Substituted Phenylalanine Derivatives with Diverse Bioorthogonal Functionalities Using a Single Pyrrolysyl-tRNA Synthetase Mutant”, ACS Chem. Biol., 2013, 8, 405-415. ARTICLE LINK
  • Odoi, K.A., Huang Y., Rezenom, Y.H. & Liu, W.R.*, “Orthogonality of the Pyrrolysyl-tRNA SynthetasetRNAPyl pairs in Escherichia coli”, PLOS One, submitted.
  • O’Donoghue, P, Prat, L., Heinemann, I., Ling, J., Odoi, K.A., Liu, W.R.* & Soll, D.*, “Near-cognate Suppression of Amber, Opal, and Quadruplet Codons Compete with Aminoacyl-tRNAPyl for Genetic Code Expansion”, FEBS Lett., 2012, 21, 393103937. (*co-corresponding authors). ARTICLE LINK
  • Wan, W, Wang, Y.-S., & Liu, W.R.*, “Genetically Encoding Bioorthogonal Functional Groups for Siteselective Protein Labeling”, Organic Chem. Curr. Res., 2012, 1:e111, DOI: 10.4172/2161-0401.1000e111
  • Wang, Z.U., Wang, Y.-S., Pai, P.-J., Russell, W.K., Russell, D.H. & Liu, W.R.*, “A Facile Method to Synthesize Histones with Posttranslational Modification Mimics”, Biochemistry, 2012, 51:5232-5234. ARTICLE LINK
  • Wang, Y.-S., Fang, X., Wallace, A.L., Wu, B. & Liu, W.R.*, “A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant Has a Broad Substrate Specificity”, J. Am. Chem. Soc., 2012, 134: 2950-2953.ARTICLE LINK
  • Weinert, B.T., Wagner, S.A., Horn, H., Henriksen, P., Liu, W.R., Olsen, J.V., Jensen, L.J. & Choudhary, C.*, “Proteome-wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation”, Sci. Signal, 2011, 4: ra48.ARTICLE LINK
  • Wang, Y.-S., Russell, W.K., Wang, Z., Wan, W., Dodd L.E., Pai, P.-J., Russell, D.H., & Liu W.R.*, “The De Novo Engineering of Pyrrolysyl-tRNA Synthetase for Genetic Incorporation of L-phenylalanine and Its Derivatives”, Mol. BioSyst., 2011, 7: 714-717. ARTICLE LINK
  • Liu, W.R.*, Wang, Y.-S. & Wan, W., “Synthesis of Proteins with Defined Posttranslational Modifications Using the Genetic Noncanonical Amino Acid Incorporation Approach”, Mol. BioSyst., 2011, 7: 38-47.ARTICLE LINK
  • Wang, Y.-H., Wu, B., Wang, Z., Huang, Y., Wan, W., Russell, W.K., Pai, P.-J., Russell, D.H. & Liu, W.R.*, “Genetic Incorporation of A Photocaged Nε-methyl-L-lysine into Proteins” Mol. Biosyst., 2010, 6: 1557-1560. This was an invited submission and featured on Molecular BioSystems 2010 Emerging Investigators Issue. ARTICLE LINK
  • Wan, W., Huang, Y., Wang, Z., Russell, W.K., Pai, P.-J., Russell, D.H. & Liu, W.R.*, “A Facile System for Genetic Incorporation of Two Different Noncanonical Amino Acids into One Protein in Escherichia coli”, Angew. Chem. Int. Ed., 2010, 49: 3211-3214. Chosen as a “Hot Paper” by the Editors for its importance in a rapidly evolving field of high current interest and announced in the journal’s press release.ARTICLE LINK
  • Huang, Y., Russell, W.K., Wan, W., Pai, P.-J., Russell, D.H. & Liu, W.*, “A convenient Method for Genetic Incorporation of Multiple Noncanonical Amino Acids into One Protein in Escherichia coli”. Mol. BioSyst. 2010, 6: 683-686. ARTICLE LINK
  • Huang, Y., Wan, W., Russell, W.K., Pai, P.-J., Wang, Z., Russell, D.H. & Liu, W.*, “Genetic Incorporation of An Aliphatic Keto-containing Amino Acid into Proteins for Their Site-specific Modificaiton”. Bioorg. Med. Chem. Lett. 2010, 20: 878-880. ARTICLE LINK

Before becoming an independent investigator

  • Brustad, E., Bushey, M.L., Lee, J.W., Groff, D., Liu W. & Schultz, P.G.* “A Genetically Encoded Boronate Containing Amino Acid” Angew. Chem. Int. Ed. Engl., 2008, 47: 8220-8223. ARTICLE LINK
  • Graziano, J.J., Liu, W., Perera, R., Geierstanger, B.H., Lesley, S.A., & Schultz, P.G. “Selecting Folded Proteins from a Library of Secondary Structural Elements”, J. Am. Chem. Soc., 2008, 130: 176-185 ARTICLE LINK
  • Tippmann, E.M.­­­+, Liu, W.+, Summerer, D., Geierstanger, B., Mack, A.V., & Schultz, P.G.*, “A Genetic Encoded Diazirine Photocrosslinker in Escherichia coli”, ChemBioChem, 2007, 8: 2210-2214 (+equally contributing authors) ARTICLE LINK
  • Liu, C.C., Braustad, E., Liu, W.* & Schultz, P.G.*, “Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed with Thrombin”, J. Am. Chem. Soc., 2007, 129: 10648-10649 (*corresponding authors in this paper)ARTICLE LINK
  • Liu, W., Brock, A., Chen, S., Chen, S. & Schultz, P.G.*, “The Genetic Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells”, Nat. Methods. 2007, 4: 239-44. ARTICLE LINK
  • Xie, J., Liu, W., & Schultz, P.G.* “A Genetic Encoded Bidentate, Metal Ion Binding Amino Acid”,Biochem Angew. Chem. Int. Ed., 2007, 46: 9239-9242. ARTICLE LINK
  • Liu, W., Alfonta, L., Mack, A.V. & Schultz, P.G.* “Structural Basis for the Recognition of p-Benzoyl-L-phenylalanyl by Evolved Aminoacyl-tRNA Synthetases”, Angew. Chem. Int. Ed., 2007, 46: 6073-6075. ARTICLE LINK
  • Liu, W., Peterson, P.E., Langston, J.A., Jin, X., Zhou, X., Fisher, A.J. & Toney, M.D.* “Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coli g-Aminobutyrate Aminotransferase”, Biochemistry 2005, 44: 2982-92.ARTICLE LINK
  • Fogle, E.J., Liu, W., Keller, J. & Toney, M.D.* “Role of Q52 in the Decarboxylation and Transamination of Dialkylglycine Decarboxylase”, Biochemistry 2005, 44: 16392-404.ARTICLE LINK
  • Liu, W., Peterson, P.E., Carter, R.J., Zhou, X., Langston, J.A., Fisher, A.J. & Toney, M.D. “Crystal Structures of Unbound and Aminooxyacetate-bound Escherichia coli g‑Aminobutyrate Aminotransferase. Biochemistry 2004, 43: 10896-905. ARTICLE LINK
  • Liu, W. & Toney, M.D. “Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase”, Biochemistry 2004, 43: 4998-5010.ARTICLE LINK
  • Liu, W., Rogers, C.J., Fisher, A.J. & Toney, M.D. “Aminophosphonate inhibitors of dialkylglycine decarboxylase: Structural basis for slow binding inhibition”, Biochemistry 2002, 41: 12320-28. ARTICLE LINK