Site menu:

Latest news:

May 2016:
Graduate Student Award: Congratulations to Chia-Hsiu Chen for receiving the Jack H. Lunsford Endowed Fellowship in Chemistry

Read more »


Search PubMed for publications by C. Hilty

64. Kim, Y., Liu, M. and Hilty, C. Parallelized Ligand Screening Using Dissolution Dynamic Nuclear Polarization. Anal. Chem. 88(22): 11178–11183 (2016). (article, web: Oct 10, 2016)

63. Zhang, G., Schilling, F., Glaser, S.J. and Hilty, C. Reaction Monitoring Using Hyperpolarized NMR with Scaling of Heteronuclear Couplings by Optimal Tracking. J. Magn. Reson. 272: 123–128 (2016). (article, web: Sep 14, 2016)

62. Zhu, Y., Chen, C.H., Wilson, Z., Savukov, I., and Hilty, C. Milli-tesla NMR and spectrophotometry of liquids hyperpolarized by dissolution dynamic nuclear polarization. J. Magn. Reson. 270: 71-76 (2016). (article, web: July 13, 2016)

61. Wang, Y., Ragavan, M., and Hilty, C. Site specific polarization transfer from a hyperpolarized ligand of dihydrofolate reductase. J. Bio. NMR: 41-48 (2016). (article, web: May 17, 2016)

60. Kim, J., Liu, M., Chen, H.Y. and Hilty, C. Determination of Intermolecular Interactions using Polarization Compensated Heteronuclear Overhauser Effect of Hyperpolarized Spins. Anal. Chem. 87(21): 11092-10987 (2015). (article, web: Oct 1, 2015)

59. Ahola, S., Zhivonitko, V. V., Mankinen, O., Zhang, G., Kantola, A. M.,Chen, H.-Y., Hilty, C., Koptyug, I. V. and Telkki, V.-V. Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis. Nat. Commun. 6(8363) DOI: 10.1038/ncomms9363 (2015). (article, web: Sep 18, 2015)

58. Min, H., Sekar, G. and Hilty, C. Polarization Transfer from Ligands Hyperpolarized by Dissolution Dynamic Nuclear Polarization for Screening in Drug Discovery. ChemMedChem 10(9): 1559-1563 (2015). (article, web: Aug 4, 2015)

57. Ardenkjaer-Larsen, J.H., Boebinger, G.S., Comment, A., Duckett, S., Edison, A.S., Engelke, F., Griesinger, C., Griffin, R.G., Hilty, C., Maeda, H., Parigi, G., Prisner, T., Ravera, E., van Bentum, J., Vega, S., Webb, A., Luchinat, C., Schwalbe, H. and Frydman, L. Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy Angew. Chem. Int. Ed. 54(32): 9162-9185 (2015). (Review article). (article, web: Jul 1, 2015)

56. Chen, H.Y. and Hilty, C. Implementation and Characterization of Flow Injection in Dissolution Dynamic Nuclear Polarization NMR Spectroscopy. ChemPhysChem 16(12): 2646-2652 (2015). (article, web: Jul 2, 2015)

55. Chen, C.H., Shih, W.C. and Hilty, C. In-Situ Determination of Tacticity, Deactivation and Kinetics in [rac-(C2H4(1-indenyl)2)ZrMe][B(C6F5)4] and [(Cp)2ZrMe][B(C6F5)4]-Catalyzed Polymerization of 1-Hexene using 13C Hyperpolarized NMR. J. Am. Chem. Soc. 137(21): 6965-6971(2015). (article, web: May 11, 2015)

54. Rembert, K.B., Okur, H.I., Hilty, C. and Cremer, P. An NH Moiety Is Not Required for Anion Binding to Amides in Aqueous Solution. Langmuir 31(11): 3459-3464 (2015). (article, web: Mar 12, 2015)

53. Chen, H.Y., Kim, Y., Nath, P., and Hilty, C. An Ultra-Low Cost NMR Device with Arbitrary Pulse Programming. J. Magn. Reson. 255: 100-105 (2015). (article, web: Mar 10, 2015)

52. Kim, Y. and Hilty, C. Affinity Screening Using Competitive Binding with Fluorine-19 Hyperpolarized Ligands. Angew. Chem. Int. Ed. 54(16): 4941-4944 (2015). (article, Feb 20, 2015)

51. Hilty, C. and Ragavan, M. Application of Blind Source Separation to Real-Time Dissolution Dynamic Nuclear Polarization. Anal. Chem. 87(2): 1004-1008 (2015). (article, web: Dec 15, 2014)

50. Hladilkova, J., Hyeda, J., Rembert, K., Okur, H., Kurra, Y., Liu, W.R., Hilty, C., Cremer, P., and Jungwirth, P. Effects of End-Group Termination on Salting-Out Constants for Triglycine. J. Phys. Chem. Lett. 4: 4096-4073 (2013). (article, web: Nov 19, 2013)

49. Chen, H.Y.,a Ragavan, M.,a and Hilty, C. Protein Folding Studied by Dissolution Dynamic Nuclear Polarization. Angew. Chem. Int. Edit. 52(35): 9192-9195 (2013). (a equal contribution). (article, web: Jul 15, 2013)

48. Chen, H.Y., Hilty, C. Hyperpolarized Hadamard Spectroscopy Using Flow NMR. Anal. Chem. 85(15): 7385-7390 (2013). (article, web: Jul 18, 2013)

47. Paterova, J., Rembert, K., Heyda, J., Kurra, Y., Okur, H., Liu, W.R., Hilty, C., Cremer, P., and Jungwirth, P. Reversal of the Hofmeister Series: Specific Ion Effects on Peptides. J. Phys. Chem. B 117(27): 8150-8158 (2013). (article, web: Jun 14, 2013)

46. Savukov, I.M., Chen, H.Y., Karaulanov, T. and Hilty, C. Method for accurate measurements of nuclear-spin optical rotation for applications in correlated optical-NMR spectroscopy. J. Magn. Reson. 232: 31-38 (2013). (article, web: Apr 24, 2013)

45. Lee, Y., Heo, G.S., Zeng, H., Wooley, K. and Hilty, C. Detection of Living Anionic Species in Polymerization Reaction using Hyperpolarized NMR. J. Am. Chem. Soc. 135(12): 4636-4639 (2013). (article, web: Mar 13, 2013)

44. Zhang, G.,a Schilling, F.,a Glaser, S. J. and Hilty, C. Chemical Shift Correlations from Hyperpolarized NMR using a single SHOT. Anal. Chem. 85(5): 2875-2881 (2013). (a equal contribution). (article, web: Feb 14, 2013)

43. Wang, Y.S., Fang, X., Chen, H.-Y., Wu, B., Wang, Z. W., Hilty, C. and Liu, W. R. Genetic Incorporation of Twelve meta-Substituted Phenylalanine Derivatives Using a Single Pyrrolysyl-tRNA Synthetase Mutant. ACS Chem. Biol. 8(2): 405-415 (2013). (article, web: Nov 19, 2012)

42. Lee, Y.,a Zeng, H.,a Ruedisser, S., Gossert, A.D. and Hilty, C. Nuclear Magnetic Resonance of Hyperpolarized Fluorine for Characterization of Protein-Ligand Interactions. J. Am. Chem. Soc. 134(42): 17448-17451 (2012). (a equal contribution). (article, web: Oct 9, 2012).
Highlighted in Nature SciBX.

41. Rembert, K.B., Paterová, J., Heyda, J., Hilty, C., Jungwirth, P. and Cremer, P.S. Molecular Mechanisms of Ion-Specific Effects on Proteins. J. Am. Chem. Soc. 134(24): 10039-10046 (2012). (article, web: Jun 11, 2012)
See also coverage in C&E News.

40. Lee, Y.,a Zeng, H.,a Mazur, A., Wegstroth, M., Carlomagno, T., Reese, M., Lee, D., Becker, S., Griesinger, C. and Hilty, C. Hyperpolarized Binding Pocket Nuclear Overhauser Effect for Determination of Competitive Ligand Binding. Angew. Chem. Int. Edit. 51(21): 5179-5182 (2012). (article, web: Apr 12, 2012)

39. Hwang, S., and Hilty, C. Folding of a tryptophan zipper peptide investigated based on Nuclear Overhauser effect and thermal denaturation. J. Phys. Chem. B 115(51): 15355-15361 (2011). (article, web: Dec. 6, 2011)

38. Ragavan, M., Chen, H.-Y., Sekar, G. and Hilty, C. Solution NMR of Polypeptides Hyperpolarized by Dynamic Nuclear Polarization. Anal. Chem. 83(15): 6054-6059 (2011). (article, web: Jun 30, 2011)

37. Hwang, S.,a Shao, Q.,a Williams, H., Hilty, C.b and Gao, Y.-Q.b Methanol Strengthens Hydrogen Bonds and Weakens Hydrophobic Interactions in Proteins - A Combined Molecular Dynamics and NMR study. J. Phys. Chem. B 115(20): 6653-6660 (2011). (a equal contribution. b joint corresponding authors). (article, web: May 2, 2011)

36. Bowen, S., Sekar, G. and Hilty, C. Rapid Determination of Biosynthetic Pathways using Fractional Isotope Enrichment and High-Resolution Dynamic Nuclear Polarization Enhanced NMR. NMR Biomed. 24(4): 1016-1022 (2011). (article, web: Mar 8, 2011)

35. Hwang, S. and Hilty, C. Folding determinants of disulfide bond forming protein B explored by solution NMR Spectroscopy. Proteins 79(5):1365-1375 (2011). (article, web: Feb 18, 2011)

34. Chen, H.-Y., Lee, Y., Bowen, S. and Hilty, C. Spontaneous emission of NMR signals in hyperpolarized proton spin systems. J. Magn. Reson. 208(2): 204-209 (2011). (article, web: Nov 11, 2010)

33. Choutko, A., Glättli, A., Fernández, C., Hilty, C., Wüthrich, K. and van Gunsteren, W.F. Membrane protein dynamics in different environments: Simulation study of the outer membrane protein X (OmpX) in a lipid bilayer and in a micelle. Eur. Biophys. J. 40(1): 39-58 (2011). (article, web: Oct 5, 2010)

32. Zeng, H., Lee, Y. and Hilty, C. Quantitative rate determination by DNP enhanced NMR of a Diels-Alder reaction. Anal. Chem. 82(21): 8897-8902 (2010). (article, web: Oct 13, 2010)

31. Hilty, C. and Bowen, S. Applications of dynamic nuclear polarization to the study of reactions and reagents in organic and biomolecular chemistry. Org. Biomol. Chem. 8(15): 3361-3365 (2010). (Emerging area article). (article, web: Jun 7, 2010)

30. Bowen, S., Hilty, C. Rapid sample injection for hyperpolarized NMR spectroscopy Phys. Chem. Chem. Phys. 12(22): 5766-5770 (2010). (article, web: May 4, 2010)

29. Hilty, C., Bowen, S. A NMR experiment based on off-the-shelf digital data acquisition equipment. J. Chem. Edu. 87(7): 747-749 (2010). (article, web: May 19, 2010)

28. Zeng, H., Bowen, S., Hilty, C. Sequentially acquired two-dimensional NMR spectra from hyperpolarized sample. J. Magn. Reson. 199 (2): 159-165 (2009). (article, web: Apr 24, 2009)

27. Bowen, S., Hilty, C. Temporal chemical shift correlations in reactions studied by hyperpolarized NMR. Anal. Chem. 81 (11): 4543-4547 (2009). (article, web: Apr 23, 2009)

26. Lee, D., Walter, K. F. A., Brückner, A.-K., Hilty, C., Becker, S., Griesinger, C. Bilayer in Small Bicelles Revealed by Lipid−Protein Interactions Using NMR Spectroscopy. J. Am. Chem. Soc. 130 (42): 13822-13823 (2008). (article, web: Sep 26, 2008)

25. Bowen, S., Zeng, H., Hilty, C. Chemical Shift Correlations from Hyperpolarized NMR by Off-Resonance Decoupling. Anal. Chem. 80 (15): 5794-5798 (2008). (article, web: Jul 8, 2008)

24. Bowen, S., Hilty, C. Time-resolved dynamic nuclear polarization enhanced NMR Spectroscopy. Angew. Chem. Int. Edit. 47 (28): 5235-5237 (2008). (article, web: Jun 2, 2008)
This article has been designated a "Hot Paper" by the journal. See also coverage in C&E News.

23. Verpillat, F., Ledbetter, M.P., Xu, S., Michalak, D.J., Hilty, C., Bouchard, L.-S., Antonijevic, S., Budker, D., Pines, A. Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor. P. Natl. Acad. Sci. USA 105 (7): 2271-2273 (2008). (article, web: Feb 11, 2008)

22. Telkki, V.-V., Hilty, C., Garcia, S., Harel, E., Pines, A. Quantifying the Diffusion of a Fluid through Membranes by Double Phase Encoded Remote Detection Magnetic Resonance Imaging. J. Phys. Chem. B 111 (50): 13929-13936 (2007). (article, web: Nov 15, 2007)
Cover article

21. Granwehr, J., Harel, E., Hilty, C., Garcia, S., Chavez, L., Pines, A., Sen, P.N., Song, Y.Q. Dispersion measurements using time-of-flight remote detection MRI. Magn. Reson. Imaging 25 (4): 449-452 (2007). (article, web: Jan 22, 2007)

20. Koptyug, I.V., Kovtunov, K.V., Burt, S.R., Anwar, M.S., Hilty, C., Han, S.I., Pines, A. and Sagdeev, R.Z. para-Hydrogen-Induced Polarization in Heterogeneous Hydrogenation Reactions. J. Am. Chem. Soc. 129 (17): 5580-5586 (2007). (article, web: Apr 5, 2007)

19. Anwar, M.S., Hilty, C., Chu, C., Bouchard, L.S., Pierce, K.L. and Pines, A. Spin coherence transfer in chemical transformations monitored by remote detection NMR. Anal. Chem. 79 (7): 2806-2811 (2007). (article, web: Mar 3, 2007)

18. Harel, E., Hilty, C., Koen, K., McDonnell, E.E. and Pines, A. Time-of-Flight Flow Imaging of Two-Phase Flow inside a Microfluidic Chip. Phys. Rev. Lett. 98: 017601 (2007). (article, web: Jan 5, 2007)

17. Schröder, L., Lowery, T.J., Hilty, C., Wemmer, D.E. and Pines, A. Targeted Molecular Imaging using Magnetic Resonance of Hyperpolarized Noble Gas. Science 314: 446-449 (2006). (article, web: Oct 20, 2006)
See press release, Perspectives, and Faculty of 1000 (Biology)

16. Baker, K.A., Hilty, C., Peti, W., Prince, A., Pfaffinger, P.J., Wider, G., Wüthrich, K. and Choe, S. NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain Biochemistry 45(6): 1663-1672 (2006). (article, web: Jan 20, 2006)

15. Hilty, C., Lowery, T.J., Wemmer, D.E. and Pines, A. Spectrally Resolved Magnetic Resonance Imaging of the Xenon Biosensor. Angew. Chem. Int. Edit. 45(1): 70-73 (2006). (article, web: Nov 28, 2005)
This article was designated a VIP and highlighted as "frontispiece".

14. Lee, D., Hilty, C., Wider, G. and Wüthrich, K. Efficient Correlation Time Measurements for Macromolecules from NMR Relaxation Interference. J. Magn. Reson. 178: 72-76 (2006). (article, web: Sep 26, 2005)

13. McDonnell, E., Han, S.I., Hilty, C., Pierce, K.L. and Pines, A. NMR analysis on microfluidic devices by remote detection. Anal. Chem. 77: 8109-8114 (2005). (article, web: Nov 17, 2005)

12. Hilty, C., McDonnell, E., Granwehr, J., Pierce, K., Han, S.I., and Pines, A. Microfluidic gas flow profiling using hyperpolarized xenon and remote detection. P. Natl. Acad. Sci. USA 102(42): 14960-14963 (2005). (article, web: Oct 18, 2005)
See press release and news article

11. Seebach, D., Mathad, R.I., Kimmerlin, T., Mahajan, Y.R., Bindschadler, P., Rueping, M., Jaun, B., Hilty, C. and Etezady-Esfarjani, T. NMR-Solution Structures in Methanol of an α-Heptapeptide, of a β32-Nonapeptide, and of an all-β3-Icosapeptide Carrying the 20 Proteinogenic Side Chains. Helv. Chim. Acta 88(7): 1969-1982 (2005). (article, web: Jul 20, 2005)

10. Hilty, C., Wider, G., Fernández, C. and Wüthrich, K. Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents. ChemBioChem 5(4): 467-473 (2004). (article, web: Apr 1, 2004)

9. Tafer, H., Hiller, S., Hilty, C., Fernández, C. and Wüthrich, K. Nonrandom Structure in the Urea-Unfolded Escherichia coli Outer Membrane Protein X (OmpX). Biochemistry 43(4): 860-869 (2004). (article, web: Jan 8, 2004)

8. Fernández, C., Hilty, C., Wider, G., Güntert, P. and Wüthrich, K. NMR structure of the integral membrane protein OmpX. J. Mol. Biol. 336(5): 1211-1221 (2003). (article, web: Feb 19, 2004)
See Faculty of 1000 (Biology)

7. Hilty, C., Wider, G., Fernández, C. and Wüthrich, K. Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles. J. Biomol. NMR 27(4): 377-382 (2003). (article)

6. Fernández, C., Hilty, C., Wider, G. and Wüthrich, K. Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy. P. Natl. Acad. Sci. USA 99(21): 13533-13537 (2002). (article, web: Oct 7, 2002)

5. Hilty, C., Fernández, C., Wider, G. and Wüthrich, K. Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles. J. Biomol. NMR 23(4): 289-301 (2002). (article)

4. Etezady-Esfarjani, T., Hilty, C., Wüthrich, K., Rueping, M., Schreiber, J. and Seebach, D. NMR-Structural Investigations of a β3-Dodecapeptide with Proteinogenic Side Chains in Methanol and in Aqueous Solutions. Helv. Chim. Acta 85(5): 1197-1209 (2002). (article, web: May 29, 2002)

3. Winterhalter, M., Hilty, C., Bezrukov, S.M., Nardin, C., Meier, W. and Fournier, D. Controlling membrane permeability with bacterial porins: application to encapsulated enzymes. Talanta 55(5): 965-971 (2001). (article, web: Nov 27, 2001)

2. Fernández, C., Hilty, C., Bonjour, S., Adeishvili, K., Pervushin, K. and Wüthrich, K. Solution NMR studies of the integral membrane proteins OmpX and OmpA from Escherichia coli. FEBS Letters 504(3): 173-178 (2001). (article, web: Aug 28, 2001)

1. Hilty, C. and Winterhalter, M. Facilitated substrate transport through membrane proteins. Phys. Rev. Lett. 86(24): 5624-5627 (2001). (article, Jun 11, 2001)

Book Chapter

Han, S.I., Granwehr, J. and Hilty, C. Broadening the Application Range of NMR and MRI by Remote Detection. In: NMR Imaging in Chemical Engineering, Wiley-VCH, Weinheim (2006). ISBN: 3-527-31234-X