Hilty Research Group

49. Chen, H.Y., ^a, Ragavan, M.,^a and Hilty, C. Protein Folding Studied by Dissolution Dynamic Nuclear Polarization. Angewandte Chemie International Edition, 52(35): 9192-9195 (2013). (^a equal contribution). (article)

48. Chen, H.Y., Hilty, C. Hyperpolarized Hadamard Spectroscopy Using Flow NMR. Analytical Chemistry, 85(15): 7385-7390 (2013). (article)

47. Paterova, J., Rembert, K., Heyda, J., Kurra, Y., Okur, H., Liu, W.R., Hilty, C., Cremer, P., and Jungwirth, P. Reversal of the Hofmeister Series: Specific Ion Effects on Peptides The Journal of Physical Chemistry B, 117(27): 8150-8158 (2013). (article)

46. Savukov, I.M., Chen, H.Y., Karaulanov, T. and Hilty, C. Method for accurate measurements of nuclear-spin optical rotation for applications in correlated optical-NMR spectroscopy. Journal of Magnetic Resonance, 232: 31-38 (2013). (article)

45. Lee, Y., Heo, G.S., Zeng, H., Wooley, K. and Hilty, C. Detection of Living Anionic Species in Polymerization Reaction using Hyperpolarized NMR Journal of the American Chemical Society, 135(12): 4636-4639 (2013). (article)

44. Zhang, G.,^a Schilling, F.,^a Glaser, S. J. and Hilty, C. Chemical Shift Correlations from Hyperpolarized NMR using a single SHOT Analytical Chemistry, 85(5): 2875-2881 (2013). (^a equal contribution). (article)

43. Wang, Y.S., Fang, X., Chen, H.-Y., Wu, B., Wang, Z. W., Hilty, C. and Liu, W. R. Genetic Incorporation of Twelve meta-Substituted Phenylalanine Derivatives Using a Single Pyrrolysyl-tRNA Synthetase Mutant. ACS Chemical Biology, 8(2): 405-415 (2013). (article)

42. Lee, Y.,^a Zeng, H.,^a Ruedisser, S., Gossert, A.D. and Hilty, C. Nuclear Magnetic Resonance of Hyperpolarized Fluorine for Characterization of Protein-Ligand Interactions. Journal of the American Chemical Society 134(42): 17448-17451 (2012). (^a equal contribution). (article).
Highlighted in Nature SciBX.

41. Rembert, K.B., Paterová, J., Heyda, J., Hilty, C., Jungwirth, P. and Cremer, P.S. Molecular Mechanisms of Ion-Specific Effects on Proteins. Journal of the American Chemical Society, 134(24): 10039-10046 (2012). (article)
See also coverage in C&E News.

40. Lee, Y.,^a Zeng, H.,^a Mazur, A., Wegstroth, M., Carlomagno, T., Reese, M., Lee, D., Becker, S., Griesinger, C. and Hilty, C. Hyperpolarized Binding Pocket Nuclear Overhauser Effect for Determination of Competitive Ligand Binding. Angewandte Chemie International Edition 51(21): 5179-5182 (2012). (article)

39. Hwang, S., and Hilty, C. Folding of a tryptophan zipper peptide investigated based on Nuclear Overhauser effect and thermal denaturation. Journal of Physical Chemistry B 115(51): 15355-15361 (2011). (article)

38. Ragavan, M., Chen, H.-Y., Sekar, G. and Hilty, C. Solution NMR of Polypeptides Hyperpolarized by Dynamic Nuclear Polarization. Analytical Chemistry 83(15): 6054-6059 (2011). (article)

37. Hwang, S.,^a Shao, Q.,^a Williams, H., Hilty, C.^b and Gao, Y.-Q.^b Methanol Strengthens Hydrogen Bonds and Weakens Hydrophobic Interactions in Proteins - A Combined Molecular Dynamics and NMR study. Journal of Physical Chemistry B 115(20): 6653-6660 (2011). (^a equal contribution. ^b joint corresponding authors). (article)

36. Bowen, S., Sekar, G. and Hilty, C. Rapid Determination of Biosynthetic Pathways using Fractional Isotope Enrichment and High-Resolution Dynamic Nuclear Polarization Enhanced NMR. NMR in Biomedicine 24(4), DOI: 10.1002/nbm.1679 (2011). (article)

35. Hwang, S. and Hilty, C. Folding determinants of disulfide bond forming protein B explored by solution NMR Spectroscopy. Proteins-Structure Function and Bioinformatics 79(5):1365-1375 (2011). (article)

34. Chen, H.-Y., Lee, Y., Bowen, S. and Hilty, C. Spontaneous emission of NMR signals in hyperpolarized proton spin systems. Journal of Magnetic Resonance 208(2): 204-209 (2011). (article)

33. Choutko, A., Glättli, A., Fernández, C., Hilty, C., Wüthrich, K. and van Gunsteren, W.F. Membrane protein dynamics in different environments: Simulation study of the outer membrane protein X (OmpX) in a lipid bilayer and in a micelle. European Biophysics Journal 40(1): 39-58 (2011). (article)

32. Zeng, H., Lee, Y. and Hilty, C. Quantitative rate determination by DNP enhanced NMR of a Diels-Alder reaction. Analytical Chemistry 82(21): 8897-8902 (2010). (article)

31. Hilty, C. and Bowen, S. Applications of dynamic nuclear polarization to the study of reactions and reagents in organic and biomolecular chemistry. Organic and Biomolecular Chemistry 8(15): 3361-3365 (2010). (Emerging area article). (article)

30. Bowen, S., Hilty, C. Rapid sample injection for hyperpolarized NMR spectroscopy Physical Chemistry Chemical Physics 12(22): 5766-5770 (2010). (article)

29. Hilty, C., Bowen, S. A NMR experiment based on off-the-shelf digital data acquisition equipment. Journal of Chemical Education 87(7): 747-749 (2010). (article)

28. Zeng, H., Bowen, S., Hilty, C. Sequentially acquired two-dimensional NMR spectra from hyperpolarized sample. Journal of Magnetic Resonance 199 (2): 159-165 (2009). (article)

27. Bowen, S., Hilty, C. Temporal chemical shift correlations in reactions studied by hyperpolarized NMR. Analytical Chemistry 81 (11): 4543-4547 (2009). (article)

26. Lee, D., Walter, K. F. A., Brückner, A.-K., Hilty, C., Becker, S., Griesinger, C. Bilayer in Small Bicelles Revealed by Lipid−Protein Interactions Using NMR Spectroscopy. Journal of the American Chemical Society 130 (42): 13822-13823 (2008). (article)

25. Bowen, S., Zeng, H., Hilty, C. Chemical Shift Correlations from Hyperpolarized NMR by Off-Resonance Decoupling. Analytical Chemistry 80 (15): 5794-5798 (2008). (article)

24. Bowen, S., Hilty, C. Time-resolved dynamic nuclear polarization enhanced NMR Spectroscopy. Angewandte Chemie International Edition 47 (28): 5235-5237 (2008). (article)
This article has been designated a "Hot Paper" by the journal. See also coverage in C&E News.

23. Verpillat, F., Ledbetter, M.P., Xu, S., Michalak, D.J., Hilty, C., Bouchard, L.-S., Antonijevic, S., Budker, D., Pines, A. Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor. Proceedings of the National Academy of Sciences of the United States of America 105 (7): 2271-2273 (2008). (article)

22. Telkki, V.-V., Hilty, C., Garcia, S., Harel, E., Pines, A. Quantifying the Diffusion of a Fluid through Membranes by Double Phase Encoded Remote Detection Magnetic Resonance Imaging. Journal of Physical Chemistry B 111 (50): 13929-13936 (2007). (article)
Cover article

21. Granwehr, J., Harel, E., Hilty, C., Garcia, S., Chavez, L., Pines, A., Sen, P.N., Song, Y.Q. Dispersion measurements using time-of-flight remote detection MRI. Magnetic Resonance Imaging 25 (4): 449-452 (2007). (article)

20. Koptyug, I.V., Kovtunov, K.V., Burt, S.R., Anwar, M.S., Hilty, C., Han, S.I., Pines, A. and Sagdeev, R.Z. para-Hydrogen-Induced Polarization in Heterogeneous Hydrogenation Reactions. Journal of the American Chemical Society 129 (17): 5580-5586 (2007). (article)

19. Anwar, M.S., Hilty, C., Chu, C., Bouchard, L.S., Pierce, K.L. and Pines, A. Spin coherence transfer in chemical transformations monitored by remote detection NMR. Analytical Chemistry 79 (7): 2806-2811 (2007). (article)

18. Harel, E., Hilty, C., Koen, K., McDonnell, E.E. and Pines, A. Time-of-Flight Flow Imaging of Two-Phase Flow inside a Microfluidic Chip. Physical Review Letters 98: 017601 (2007). (article)

17. Schröder, L., Lowery, T.J., Hilty, C., Wemmer, D.E. and Pines, A. Targeted Molecular Imaging using Magnetic Resonance of Hyperpolarized Noble Gas. Science 314: 446-449 (2006). (article)
See press release, Perspectives, and Faculty of 1000 (Biology)

16. Baker, K.A., Hilty, C., Peti, W., Prince, A., Pfaffinger, P.J., Wider, G., Wüthrich, K. and Choe, S. NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain Biochemistry 45(6): 1663-1672 (2006). (article)

15. Hilty, C., Lowery, T.J., Wemmer, D.E. and Pines, A. Spectrally Resolved Magnetic Resonance Imaging of the Xenon Biosensor. Angewandte Chemie International Edition 45(1): 70-73 (2006). (article)
This article was designated a VIP and highlighted as "frontispiece".

14. Lee, D., Hilty, C., Wider, G. and Wüthrich, K. Efficient Correlation Time Measurements for Macromolecules from NMR Relaxation Interference. Journal of Magnetic Resonance 178: 72-76 (2006). (article)

13. McDonnell, E., Han, S.I., Hilty, C., Pierce, K.L. and Pines, A. NMR analysis on microfluidic devices by remote detection. Analytical Chemistry 77: 8109-8114 (2005). (article)

12. Hilty, C., McDonnell, E., Granwehr, J., Pierce, K., Han, S.I., and Pines, A. Microfluidic gas flow profiling using hyperpolarized xenon and remote detection. Proceedings of the National Academy of Sciences of the United States of America 102(42): 14960-14963 (2005). (article)
See press release and news article

11. Seebach, D., Mathad, R.I., Kimmerlin, T., Mahajan, Y.R., Bindschadler, P., Rueping, M., Jaun, B., Hilty, C. and Etezady-Esfarjani, T. NMR-Solution Structures in Methanol of an α-Heptapeptide, of a β³/β²-Nonapeptide, and of an all-β³-Icosapeptide Carrying the 20 Proteinogenic Side Chains. Helvetica Chimica Acta 88(7): 1969-1982 (2005). (article)

10. Hilty, C., Wider, G., Fernández, C. and Wüthrich, K. Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents. ChemBioChem 5(4): 467-473 (2004). (article)

9. Tafer, H., Hiller, S., Hilty, C., Fernández, C. and Wüthrich, K. Nonrandom Structure in the Urea-Unfolded Escherichia coli Outer Membrane Protein X (OmpX). Biochemistry 43(4): 860-869 (2004). (article)

8. Fernández, C., Hilty, C., Wider, G., Güntert, P. and Wüthrich, K. NMR structure of the integral membrane protein OmpX. Journal of Molecular Biology 336(5): 1211-1221 (2003). (article)
See Faculty of 1000 (Biology)

7. Hilty, C., Wider, G., Fernández, C. and Wüthrich, K. Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles. Journal of Biomolecular NMR, 27(4): 377-382 (2003). (article)

6. Fernández, C., Hilty, C., Wider, G. and Wüthrich, K. Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America 99(21): 13533-13537 (2002). (article)

5. Hilty, C., Fernández, C., Wider, G. and Wüthrich, K. Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles. Journal of Biomolecular NMR 23(4): 289-301 (2002). (article)

4. Etezady-Esfarjani, T., Hilty, C., Wüthrich, K., Rueping, M., Schreiber, J. and Seebach, D. NMR-Structural Investigations of a β³-Dodecapeptide with Proteinogenic Side Chains in Methanol and in Aqueous Solutions. Helvetica Chimica Acta 85(5): 1197-1209 (2002). (article)

3. Winterhalter, M., Hilty, C., Bezrukov, S.M., Nardin, C., Meier, W. and Fournier, D. Controlling membrane permeability with bacterial porins: application to encapsulated enzymes. Talanta 55(5): 965-971 (2001). (article)

2. Fernández, C., Hilty, C., Bonjour, S., Adeishvili, K., Pervushin, K. and Wüthrich, K. Solution NMR studies of the integral membrane proteins OmpX and OmpA from Escherichia coli. FEBS Letters 504(3): 173-178 (2001). (article)

1. Hilty, C. and Winterhalter, M. Facilitated substrate transport through membrane proteins. Physical Review Letters 86(24): 5624-5627 (2001). (article)

Book Chapter

Han, S.I., Granwehr, J. and Hilty, C. Broadening the Application Range of NMR and MRI by Remote Detection. In: NMR Imaging in Chemical Engineering, Wiley-VCH, Weinheim (2006). ISBN: 3-527-31234-X