News Headlines

  • December 2015: Congratulations to D.J. and Seth! D.J. was selected to give a research presentation and Seth was selected to give a Data Blitz talk at the Bioinorganic Chemistry GRS.
  • November 2015: Congratulations to D.J. and Seth! They were awarded Travel Award Scholarships to attend the 2016 Metals in Biology GRC and Bioinorganic Chemistry GRS in Ventura, CA, where they both will present posters.
  • October 2015: Congratulations to Shachin and D.J. for winning prizes for their poster presentations at the 7th annual A.I. Scott Research Symposium!
  • August 2015: D.J. recently placed 2nd in the BASF Graduate Student Symposium poster session. Congrats!
  • July 2015: Congratulations to Dr. Jimmy V! He was awarded a Research Associateship at the Naval Research Laboratory in DC. Jimmy-V will work with Dr. Igor Medintz starting in the fall. Good luck James! You will be missed!
  • June 2015: Welcome to 2015 summer REU students Steven Havens (Texas A&M University) and Kathy Senn (University of Wisconsin Oshkosh).
  • May 2015: Congratulations to Nick and Deepika for their recently published Biochemistry article. Read more.

David P. Barondeau

    Dr. Barondeau

  • My group couples X-ray crystallography with molecular biology, biochemistry, spectroscopy and biophysical methods such as small angle X-ray scattering and deuterium exchange mass spectrometry to understand the chemistry underlying biological mechanisms. Students have opportunities for collaborative interdisciplinary research, X-ray data collection at national synchrotron facilities, and participation in international meetings and symposiums.
  • The Barondeau research group greatly benefits from the service facilities of the ILSB. The group particularly benefits from the structural biology infrastructure included in the building, including the X-ray, mass spectrometry, and microscopy facilities. Interactions with the other structural biology groups from across campus result in an exchange of ideas, enhanced problem solving, and increased productivity.
  • Eukaryotic Fe-S Cluster Biogenesis

    Metal ions are required for many biochemical reactions, but are also a major source of toxic byproducts called reactive oxygen species.  Humans have specific protein escort and storage systems that minimize this undesired reactivity.  Defects in one of these systems, Fe-S cluster biosynthesis, are correlated with mitochondria dysfunction and implicated in neurodegenerative diseases (such as Parkinson's and Alzheimer’s), genomic instability (which leads to cancer), and heart disease.  The Barondeau group is studying the mechanism of how these escort proteins work together to make functional proteins and how defects in these systems lead to toxic byproducts and human disease. 

    Function discovery of new class of [FeFe]-hydrogenase proteins
    The development of low-emission fuels is one of the greatest challenges facing our society. An ideal solution would be to capture light energy from the sun and then store and transfer this energy in the form of hydrogen gas. Toward that end, enzymes known as hydrogenases that produce hydrogen can be engineered into photosynthetic green algae or cyanobacteria. But sustained hydrogen production is currently limited because oxygen, which is generated during photosynthesis, inactivates hydrogenase. To address this problem, the Barondeau group has identified and is now characterizing a novel class of hydrogenase that may be more resistant to oxygen inactivation.

Prospective students

If you are interested in making the Barondeau group your next home away from home, please contact Dr. Barondeau or one of the graduate students.


Contact Us - Barondeau Group

  • Address:301 Old Main Drive, ILSB 1196, College Station, TX 77843
  • Phone:(979) 458-0735
  • Fax:(979) 458-5732