Department of Chemistry
A headshot

John Gladysz
Distinguished Professor
Dow Chair in Chemical Invention

Contact
Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-845-1399
F: 979-845-4719
gladysz@chem.tamu.edu

Researcher ID

Current Activities

My research has traditionally been centered around organometallic chemistry, and from this core area branches into catalysis, organic synthesis, enantioselective reactions, stereochemistry, mechanism, and materials chemistry. About half of my group is involved with catalysis projects. Areas receiving emphasis include (a) structurally novel new families of highly enantioselective catalysts, (b) metal-containing "organocatalysts" and (c) recoverable catalysts, particularly those with "ponytails" of the formula (CH2)m(CF2)nF; these can be recycled via "fluorous" liquid or solid phases, such as Teflon. The other half of my group synthesizes organometallic building blocks for molecular devices. These include (a) molecular wires composed of metal endgroups and linear (sp) carbon chains, including stable species with C28 bridges, (b) analogs in which the charge-transmitting bridges are insulated by a pair of polymethylene or (CH2)n chains that adopt a double-helical conformation, (c) polygons and multistranded molecular wires based upon such building blocks, and (d) molecular gyroscopes and compasses consisting of a rotating MLn fragment and an external cage (stator) that insulates the rotator from neighboring molecules, exactly as with the commercial gyroscopes used for aircraft and space-station navigation.

Educational Background

B. S., 1971, University of Michigan

Ph. D., 1974, Stanford University

Awards & Recognition

  • Alfred P. Sloan Foundation Fellow 1980-1984
  • Camille and Henry Dreyfus Teacher-Scholar 1980-1985
  • Arthur C. Cope Scholar Award (American Chemical Society) 1988
  • University of Utah Distinguished Research Award 1992
  • American Chemical Society Award in Organometallic Chemistry 1994
  • von Humboldt Foundation Research Award for Senior Scientists 1995-1996
  • Fellow, American Association for the Advancement of Science 2004
  • International Fluorous Technologies Award 2007
  • Fellow of the American Chemical Society (inaugural 2009 class) 2009
  • Editor-in-Chief of Organometallics 2010-2014
  • Texas A&M Distinguished Achievement Award in Research 2013
  • Royal Society of Chemistry Award in Organometallic Chemistry 2013
  • Fellow of the Royal Society of Chemistry 2014
  • Texas A&M Foundation Partner in Philanthropy Faculty Award 2017

Selected Publications

  • "Cobalt(III) Werner Complexes with 1,2-Diphenylethylenediamine Ligands: Readily Av­ailable, Inexpensive, and Modular Chiral Hydrogen Bond Donor Catalysts for Enantiosel­ective Organic Synthesis", Lewis, K. G.; Ghosh, S. K.; Bhuvanesh, N.; Gladysz, J. A. ACS Cent. Sci. 2015, 1, 50-56. DOI: 10.1021acscentsci.5b00035.

  • "Activation of Single Component Nickel(II) Polyethylene Catalysts via Phase Transfer of Fluorous Phosphine Ligands", Xi, Z.; Bazzi, H. S.; Gladysz, J. A. J. Am. Chem. Soc. 2015, 137, 10930-10933. DOI: 10.1021/jacs.5b06562.

  • "Werner Complexes with w-Dimethylaminoalkyl Substituted Ethylenediamine Lig­ands: Bifunctional Hydrogen Bond Donor Catalysts for Highly Enantioselective Michael Additions", Ghosh, S. K.; Ganzmann, C.; Bhuvanesh, N.; Gladysz, J. A. Angew. Chem., Int. Ed. 2016, 55, 4356-4360. DOI: 10.1002/anie.201511314.

  • "Gyroscope Like Complexes based upon Dibridgehead Diphosphine Cages that are Ac­cessed by Three Fold Intramolecular Ring Closing Metatheses and Encase Fe(CO)3, Fe­(CO)2(NO)+ and Fe(CO)3(H)+ Rotators", Lang, G. M.; Shima, T.; Wang, L.; Cluff, K. J.; Skopek, K.; Hampel, F.; Blümel, J.; Gladysz, J. A. J. Am. Chem. Soc. 2016, 138, 7649-7663. DOI: 10.1021/jacs.6b03178.
  • "Homeomorphic Isomerization as a Design Element in Container Molecules; Binding, Displacement, and Selective Transport of MCl2 Species (M = Pt, Pd, Ni)", Kharel, S.; Jo­shi, H.; Bierschenk, S.; Stollenz, M.; Taher, D.; Bhuvanesh, N.; Gladysz, J. A. J. Am. Chem. Soc. 2017, 139, 2172-2175. DOI: 10.1021/jacs.6b12788.