Department of Chemistry
A headshot

Hongcai (Joe) Zhou
Robert A. Welch Foundation Chair

Other Affiliations
Materials Sciences & Engineering

Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-845-4034
F: 979-845-1595

Researcher ID

Current Activities

Nature has demonstrated the extraordinary ability in biological systems to form large and intricate supramolecular arrays from small and simple building blocks, giving rise to a wide variety of structures and functions. Coordination-driven self-assembly has received considerable attention and produced numerous examples of chemically interesting and aesthetically appealing self-assembled structures. For example, nanoscopic molecular cages, can act as molecular hosts for a variety of potential applications, namely molecular recognition, drug delivery, and chemical sensing. They can also be applied as molecular reactors for highly selective reactions (Ex. size- or enantio-selective catalysis and bond activation in a confined space), basic building units for the construction of extended porous materials, and artificial enzymes.

Porous solid materials have captured the imagination of materials scientists and offer great promise in gas storage, separations, catalysis, and drug delivery applications. In the last decade, the study of Metal-Organic Frameworks (MOFs), Porous Polymer Networks (PPNs), and Porous Coordination Cages (PCCs) have become some of the most rapidly developing fields in materials chemistry. These materials represent several different classes of permanently porous materials, due to their ability to maintain a rigid framework surrounding void spaces upon guest removal. Porous materials have a number of applications, from gas storage and separation, to drug delivery and catalysis. These applications take advantage of the physisorptive properties of these materials to sequester and concentrate substrates within their pores. The highly tunable pore environments of MOFs, PPNs, and PCCs allows for the fine control of these capture properties, allowing for the densification of gaseous substrates compared to bulk storage, or for the localized concentration of substrates near a catalytically active site. The development of these tailored materials utilizes aspects of organic synthesis, analytical chemistry, and materials science and engineering leading to a truly multidisciplinary field.

Educational Background

Ph.D., 2000, Texas A&M University

Postdoctoral Fellow, 2000-2002, Harvard University

Awards & Recognition

  • NSF CAREER Award
  • Cottrell Scholar Award
  • Research Innovation Award
  • Miami University Distinguished Scholar Award
  • Air Products Faculty Excellence Award

Selected Publications

  • Lu, W.; Bosch, M.; Yuan, D.; Zhou, H. C., Cost‐Effective Synthesis of Amine‐Tethered Porous Materials for Carbon Capture. ChemSusChem 2015, 8 (3), 433-438.
  • Fang, Y.; Xiao, Z.; Li, J.; Lollar, C.; Liu, L.; Lian, X.; Yuan, S.; Banerjee, S.; Zhang, P.; Zhou, H. C., Formation of a Highly Reactive Cobalt Nanocluster Crystal within a Highly Negatively Charged Porous Coordination Cage. Angew. Chem. Int. Ed. 2018, 57 (19), 5283-5287.
  • Lian, X.; Erazo-Oliveras, A.; Pellois, J.-P.; Zhou, H.-C., High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks. Nat. Commun. 2017, 8 (1), 2075.
  • Yuan, S.; Chen, Y.-P.; Qin, J.-S.; Lu, W.; Zou, L.; Zhang, Q.; Wang, X.; Sun, X.; Zhou, H.-C., Linker Installation: Engineering Pore Environment with Precisely Placed Functionalities in Zirconium MOFs. JACS 2016, 138 (28), 8912-8919.
  • Li, H.; Wang, K.; Sun, Y.; Lollar, C. T.; Li, J.; Zhou, H.-C., Recent advances in gas storage and separation using metal–organic frameworks. Mater. Today 2018, 21 (2), 108-121.