Department of Chemistry
A headshot

François Gabbaï
Professor
A.E. Martell Endowed Chair

Contact
Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-862-2070
F: 979-845-4719
gabbai@chem.tamu.edu

Researcher ID

Current Activities

Our research is concerned with the chemistry of both organic and organometallic polyfunctional Lewis acids. While an important component of our work deals with the synthesis of new examples of such polyfunctional Lewis acids, it is our ultimate intent to harness and utilize the cooperative effects occurring in such systems for the discovery of unusual structures, bonding modes, supramolecules and reactivities. Our research efforts present important ramifications in the domain of molecular recognition, supramolecular materials and catalysis.

Synthesis: Organic and organometallic synthesis lies at the focal point of our program. We strive to discover high yield synthetic routes for the preparation of both organic and organometallic polyfunctional Lewis acids. These efforts have allowed us to prepare a variety of bidentate and tridentate Lewis acids in which the electrophilic sites are simple carbocations or main-group elements such as mercury(II) and boron(III).

Bonding: In an effort to broaden our fundamental understanding of bonding interactions, we study atypical bonding situations that might arise in the chemistry of polyfunctional Lewis acids. While we have been interested in the formation of radicals featuring one-electron s-bonds, some of our current efforts are devoted to the synthesis of fluoronium ions.

Molecular recognition: Some of these polyfunctional Lewis acids act as polytopic receptors for anions. The significance of this research relates to the discovery of new molecular recognition units for sensory application. For example, we have recently demonstrated that boron-based bidentate Lewis acids can be used as selective colorimetric sensors for fluoride ions. Taking into account the importance of fluoride in the treatment of osteoporosis and in dental care, such sensors may find biomedical applications.

Supramolecular materials: In addition to discovering receptors for small organic molecules including diazines, ketones, aldehydes, oxiranes, and phosphonates, we have also found that trimeric perfluoro-ortho-phenylene mercury, a tridentate Lewis acid, is able to complex many arenes including benzene, naphthalene, biphenyl and pyrene. The resulting adducts form unusual supramolecular binary stacks. In addition, these adducts display unique luminescent properties which make them useful materials for organic light emitting diodes (OLED). Some of these adducts form microporous solids used for gas storage.

Educational Background

Ph. D., 1994, University of Texas at Austin

Alexander von Humboldt Postdoctoral Fellow, 1994-1996, Technical University of Munich

European Community Research Fellow (Habilitation), 1996-1998, Technical University of Munich

Awards & Recognition

  • Member of the Inorganic Syntheses board, 2013-present
  • Vice-Chair (2014) and Chair (2016) of the Inorganic Chemistry Gordon Conference
  • Appointed as Arthur E. Martell Chair of Chemistry, 2014
  • F. Albert Cotton Award in Synthetic Inorganic Chemistry, 2016
  • Editorial Board Member of Chemistry Select, 2016-present
  • Editorial Board Member of Chem, 2016-present
  • Fellow of the Royal Society of Chemistry (2013)
  • Associate Editor for Organometallics
  • Fellows of the American Chemical Society (2011)
  • Dalton Transactions North American Lectureship (2009)
  • TMR European Commission Research Fellow
  • Alexander von Humbodlt Fellow
  • NSF CAREER Award (2001)

Selected Publications

  • D. Tofan, F. P. Gabbaï, "Fluorinated Antimony(V) Derivatives: Strong Lewis Acidic Properties and Application to the Complexation of Formaldehyde in Aqueous Solutions" Chem. Sci. 2016, 7, 6768.
  • J. S. Jones, F. P. Gabbaï, "Coordination and Redox Non-Innocent Behavior of Ambiphilic Ligands Containing Antimony" Acc. Chem. Res. 2016, 49, 857–867.
  • T. W. Hudnall, C. L. Dorsey, J. S. Jones, F. P. Gabbaï, "Stepwise Reduction of α-Phosphonio-Carbocation to a Crystalline Phosphorus Radical Cation and an Acridinyl-Phosphorus Ylide" Chem. Eur. J. 2016, 22, 2882-2886.
  • H. Yang, F. P. Gabbaï, "Activation of a Hydroamination Gold Catalyst by Oxidation of a Redox-Noninnocent Chlorostibine Z-Ligand" J. Am. Chem. Soc. 2015, 137, 13425-13432.
  • K. Chansaenpak, M. Wang, Z. Wu, R. Zaman, Z. Li, F. P. Gabbaï, "[18F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging" Chem. Commun. 2015, 51, 12439-12442.