David H. Russell
Head, Department of Chemistry
Professor
Ph. D., University of Nebraska
Contact
Information:
Department of Chemistry
Texas A&M University
College Station, TX 77842
Phone:
(979) 845-3345
Fax: (979) 845-9485
russell@chem.tamu.edu
Research activities in my group are in the general area of mass spectrometry and gas-phase ion chemistry. The research projects include biological chemistry, fundamental gas-phase ion chemistry, and instrumentation development, especially laser-mass spectrometry instruments. The biological mass spectrometry research program focuses on studies of peptides and proteins as well as the development of more versatile and sensitive methods for structural characterization. Efforts are underway to extend these methods to characterization of DNA. Matrix-assisted laser desorption ionization (MALDI) is the primary ionization method used in this research and time-of-flight (TOF) and Fourier-transform ion cyclotron resonance (FTICR) are the mass analyzers. Novel instrumentation plays an increasingly important role in biological mass spectrometry. We are actively pursuing new instrument methods centered around the TOF and FTICR instruments. The instrument inventory includes five TOF instruments, two magnetic sector instruments, and a quadrupole instrument for electrospray ionization. In addition, two novel tandem TOF and two state-of-the-art FTICR instruments are dedicated to my research program.
"Observation of Conserved Solution-Phase Secondary Structure in Gas-Phase Tryptic Peptides," Brandon T. Ruotolo, Guido F. Verbeck, Lisa M. Thomson, Kent J. Gillig, and David H.Russell, JACS, 2002,124, 16, 4214-4215.
"Accurate Mass Measurement of DNA Oligonucleotide Ions Using High-Resolution Time-of-Flight Mass Spectrometry," John K. Koomen, William K. Russell, Shane E. Tichy, and David H. Russell, J. Mass Spectrom., 2002, 37, 357-371.
"Proteolysis in Mixed Organic-Aqueous Solvent Systems: Applications for Peptide Mass Mapping Using Mass Spectrometry," William K. Russell, Zee-Yong Park, and David H Russell, Anal. Chem., 2001, 73, 2682-2685
"Identification of Individual Proteins in Complex Protein Mixtures by High Resolution, High Mass Accuracy MALDI TOF Mass Spectrometry Analysis of In-Solution Thermal Denaturation/Enzymatic Digestion," Zee-Yong Park and David H. Russell, Anal Chem., 2001, 73, 2558-2564.
"Surface-Induced Dissociation (SID) on a MALDI-Ion Mobility-Orthogonal-Time-of-Flight Mass Spectrometer: Sequencing Peptides from an "In-solution" Protein Digest," Earle G. Stone, Kent J. Gillig, Brandon T. Ruotolo, Katrin Fuhrer, Marc Gonin, Albert J. Schultz, and David H. Russell, Anal. Chem., 2001, 73, 2233-2238.
