Department of Chemistry
A headshot of Arthur Laganowsky

Arthur Laganowsky
Assistant Professor

Contact
Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-458-0357
F: 979-845-4719
alaganowsky@chem.tamu.edu

Research Activities

A long-term research goal of our group is to determine the molecular basis behind protein-lipid interactions and how these interactions can modulate the structure and function of membrane proteins, including their interactions with signaling molecules. What determines the selectivity of membrane proteins towards lipids, and the coupling between lipid binding events and function remains a key knowledge gap in the field; one that if addressed will significantly advance our understanding of how lipids participate in both normal and pathophysiological processes of membrane proteins. Therefore, there is a critical need to expand our fundamental knowledge in this emerging field by applying and developing innovative approaches to elucidate how lipids modulate the structure function of membrane proteins. To this end, we are studying a number of ion channels, receptors and other types of membrane proteins.

Educational Background

B.S., 2004, Biological Sciences, California State University, Chico, CA

M.S., 2006, Biological Sciences, California State University, Chico, CA

Ph.D., 2011, Chemistry and Molecular Biology, University of California, Los Angeles, California

Postdoc, 2011-2014, Physical and Theoretical Chemistry, University of Oxford, Oxford, UK

Awards & Recognition

  • NIH New Innovator Award, 2016

Selected Publications

  • Cong X, Liu Y, Liu W, Liang X, Russell DH, Laganowsky A. Determining Membrane Protein-Lipid Binding Thermodynamics Using Native Mass Spectrometry. J Am Chem Soc. 2016 Apr 6;138(13):4346-9.
  • Laganowsky A,Reading E, Allison TM, Ulmschneider MB, Degiacomi MT, Baldwin AJ, Robinson CV. Membrane proteins bind lipids selectively to modulate their structure and function. Nature. 2014 Jun 5;510(7503):172-5.
  • Allison TM, Reading E, Liko I, Baldwin AJ, Laganowsky A, Robinson CV. Quantifying the stabilizing effects of protein-ligand interactions in the gas phase. Nat Commun. 2015 Oct 6;6:8551.
  • Laganowsky A, Reading E, Hopper JT, Robinson CV. Mass spectrometry of intact membrane protein complexes. Nat Protoc. 2013 Apr;8(4):639-51.
  • Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 9;335(6073):1228-31.