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AMMONIA-AMMONIUM CHLORIDE - HYDROXIDE BUFFER
MSDS Number: A5728 --- Effective Date: 09/08/99
1. Product Identification
Synonyms: Ammonia-Ammomium Chloride Buffer TS
CAS No.: Not applicable to mixtures.
Molecular Weight: Not applicable to mixtures.
Chemical Formula: Not applicable to mixtures.
Product Codes:
J.T. Baker: 5904
Mallinckrodt: H004
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------- --------- Ammonium Hydroxide 1336-21-6 5.2% Yes Ammonium Chloride 12125-02-9 0.67% No Water 7732-18-5 94% No
3. Hazards Identification
Emergency Overview
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POISON! DANGER! CORROSIVE. MAY BE FATAL IF SWALLOWED OR INHALED. MIST AND VAPOR CAUSE BURNS TO EVERY AREA OF CONTACT.J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Poison)
Flammability Rating: 1 - Slight
Reactivity Rating: 2 - Moderate
Contact Rating: 3 - Severe (Corrosive)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES
Storage Color Code: White Stripe (Store Separately)
-----------------------------------------------------------------------------------------------------------Potential Health Effects
----------------------------------The following hazards are for concentrated solutions. Hazards of less concentrated solutions may be reduced. Degree of hazard for reduced concentrations is not currently addressed in the available literature.
Inhalation:
Vapors and mists cause irritation to the respiratory tract. Higher concentrations can cause burns, pulmonary edema and death. Brief exposure to 5000 ppm can be fatal.
Ingestion:
Toxic! May cause corrosion to the esophagus and stomach with perforation and peritonitis. Symptoms may include pain in the mouth, chest, and abdomen, with coughing, vomiting and collapse. Ingestion of as little as 3-4 mL may be fatal.
Skin Contact:
Causes irritation and burns to the skin.
Eye Contact:
Vapors cause irritation. Splashes cause severe pain, eye damage, and permanent blindness.
Chronic Exposure:
Repeated exposure may cause damage to the tissues of the mucous membranes, upper respiratory tract, eyes and skin.
Aggravation of Pre-existing Conditions:
Persons with pre-existing eye disorders or impaired respiratory function may be more susceptible to the effects of this material.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately. Immediate action is critical to minimize possibility of blindness.
5. Fire Fighting Measures
Fire:
Not considered to be a fire hazard.
Explosion:
Not considered to be an explosion hazard. Flammable vapors may accumulate in confined spaces.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire. Use water spray to blanket fire, cool fire exposed containers, and to flush non-ignited spills or vapors away from fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Ventilate area of leak or spill. Keep unnecessary and unprotected people away from area of spill. Wear appropriate personal protective equipment as specified in Section 8. Contain and recover liquid when possible. Do not flush caustic residues to the sewer. Residues from spills can be diluted with water, neutralized with dilute acid such as acetic, hydrochloric or sulfuric. Absorb neutralized caustic residue on clay, vermiculite or other inert substance and package in a suitable container for disposal. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802.
7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Separate from incompatibilities. Store below 25C. Protect from freezing. Protect from direct sunlight. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
50 ppm (NH3)
-ACGIH Threshold Limit Value (TLV):
25 ppm (NH3) (TWA) 35 ppm (STEL)
Ammonium chloride:
-ACGIH Threshold Limit Value (TLV):
10 mg/m3 (TWA); 20 mg/m3 (STEL) Fume
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a full facepiece respirator with an ammonia/methylamine cartridge may be worn up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact. Neoprene and nitrile rubber are recommended materials. Polyvinyl alcohol is not recommended.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
Clear, colorless solution.
Odor:
Ammonia odor.
Solubility:
Soluble in water.
No information found.
ca. 1.0
pH:
10.10 (+/- 0.02) @ 25C
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
ca. 100C (ca. 212F)
Melting Point:
ca. 0C (ca. 32F)
Vapor Density (Air=1):
Essentially the same as water.
Vapor Pressure (mm Hg):
Essentially the same as water.
Evaporation Rate (BuAc=1):
Essentially the same as water.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Burning may produce ammonia, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Acids, acrolein, dimethyl sulfate, halogens, silver nitrate, propylene oxide, nitromethane, silver oxide, silver permanganate, oleum, beta-propiolactone. Most common metals.
Conditions to Avoid:
Heat, sunlight, incompatibles, sources of ignition.
11. Toxicological Information
For ammonium hydroxide:
oral rat LD50: 350 mg/kg; eye, rabbit, standard Draize, 250 ug; severe, investigated as a mutagen.
For ammonia:
inhalation rat LC50: 2000 ppm/4-hr; investigated as a tumorigen, mutagen.
Ammonium Chloride:
Oral rat LD50 : 1650 mg/kg
Investigated as a mutagen.--------\Cancer Lists\------------------------------------------------------ ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------------------------------------ ----- ----------- ------------- Ammonium Hydroxide (1336-21-6) No No None Ammonium Chloride (12125-02-9) No No None Water (7732-18-5) No No None
12. Ecological Information
Environmental Fate:
This material is not expected to significantly bioaccumulate.
Environmental Toxicity:
This material is expected to be very toxic to aquatic life. The LC50/96-hour values for fish are less than 1 mg/l. The EC50/48-hour values for daphnia are less than 1 mg/l.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste facility. Although not a listed RCRA hazardous waste, this material may exhibit one or more characteristics of a hazardous waste and require appropriate analysis to determine specific disposal requirements. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
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Proper Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S. (AMMONIUM HYDROXIDE)
Hazard Class: 8, 6.1
UN/NA: UN2922
Packing Group: III
Information reported for product/size: 1LInternational (Water, I.M.O.)
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Proper Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S. (AMMONIUM HYDROXIDE)
Hazard Class: 8, 6.1
UN/NA: UN2922
Packing Group: III
Information reported for product/size: 1LInternational (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S. (AMMONIUM HYDROXIDE)
Hazard Class: 8, 6.1
UN/NA: UN2922
Packing Group: III
Information reported for product/size: 1L
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Ammonium Hydroxide (1336-21-6) Yes Yes Yes Yes Ammonium Chloride (12125-02-9) Yes Yes Yes Yes Water (7732-18-5) Yes Yes Yes Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil. ----------------------------------------------- ----- --- ---- ----- Ammonium Hydroxide (1336-21-6) Yes Yes No Yes Ammonium Chloride (12125-02-9) Yes Yes No Yes Water (7732-18-5) Yes Yes No Yes --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg. ----------------------------------------- --- ----- ---- -------------- Ammonium Hydroxide (1336-21-6) No No No No Ammonium Chloride (12125-02-9) No No No No Water (7732-18-5) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Ammonium Hydroxide (1336-21-6) 1000 No No Ammonium Chloride (12125-02-9) 5000 No No Water (7732-18-5) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: No SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No Reactivity: No (Mixture / Liquid)Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
16. Other Information
NFPA Ratings: Health: 3 Flammability: 1 Reactivity: 0
Label Hazard Warning:
POISON! DANGER! CORROSIVE. MAY BE FATAL IF SWALLOWED OR INHALED. MIST AND VAPOR CAUSE BURNS TO EVERY AREA OF CONTACT.
Label Precautions:
Do not get in eyes, on skin, or on clothing.
Do not breathe vapor or mist.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. IMMEDIATE ACTION IS ESSENTIAL FOR EYE EXPOSURES. In all cases get medical attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 1, 3, 9.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)