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Dr. Russell
http://www.chem.tamu.edu/rgroup/russell/ The Russell group focuses on analytical chemistry, mass spectrometry, ion mobility spectrometry, and proteomics. Dr. Russell directs the Laboratory for Biological Mass Spectrometry (LBMS) which provides expertise in mass spectrometry to all TAMU research activities. This includes the analysis of small molecules as well as proteins, DNA, RNA, and natural products. The LBMS maintains a complete inventory of routine and cutting-edge mass spectrometers. One project involves developing a novel hybrid linear ion trap (LIT)-ion mobility (IM)-time of flight (TOF) mass spectrometry for structural characterization of gas-phase ions, including small molecules and macromolecules. The instrument should allow rapid, high-throughput mass spectrometry for structural characterization of gas-phase peptide and protein ions. It will be used to measure collision cross-sections of low internal energy ions, which can then be combined with molecular dynamics and computation chemistry methods to extract structure (shape) information for the ion. The instrument will combine LIT technology, periodic focusing ion-guide mobility drift cell, high-resolution orthogonal-TOFMS, and multi-anode, micro-array ion detection, which can be used for rapid (micro-second) post-ionization separation and mass analysis of ions formed by electrospray ionization or matrix-assisted laser desorption ionization as well as small molecule ion sources, i.e., EI, CI, and PI/MPI. IM-MS structural studies can be performed on products of ion-molecule and ion-ion reactions, solvated species, ion clusters which are weakly bound, and species which are intrinsically unstable, i.e., non-covalent protein complexes. |
